Clinical trials: Tympanoplasty
Perforation of Eardrum.
Tympanoplasty Using Conchal Cavum Approach and Conchal Pericondrium
Tympanoplasty -- conchal cavum approach is a modification of Heermann endural approach to repair broken eardrums. The Heermann approach is a well recognized procedure, in common clinical practise for years.
- Trial name
- NCT02000843
- Testing
- tympanoplasty -- conchal cavum approach
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Hearing Loss,Conductive
Half-thickness Tragal Cartilage Graft vs Temporalis Fascia Graft Tympanoplasty Type I
The rationale of this study is to find out the surgical outcome and success rates of tragal cartilage and temporalis fascia, subsequently to develop guide line in light of the results of this study for our department as our…
- Trial name
- PTA (NCT03817242)
- Testing
- Tympanoplasty using tragal cartilage graft, Tympanoplasty using temporalis fascia graft
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Lady Reading Hospital, Pakistan
Tympanic Membrane Perforation
Eustachian Tube Function and Myringoplasty/Tympanoplasty
This study will determine whether the likely success of closing a hole in the eardrum can be predicted by testing Eustachian tube function.
- Trial name
- NCT01766856
- Testing
- Eustachian tube function testing
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Oropharyngeal Leak Pressure, Airway Management
Effects of Video LMA Cuff Pressure in Tympanoplasty.
This prospective observational study aims to evaluate the effects of different cuff pressure levels of the Video Laryngeal Mask Airway (Video LMA) on airway safety, ventilation efficacy, and postoperative pharyngeal symptoms in…
- Conditions
- Oropharyngeal Leak Pressure, Airway Management, Postoperative Sore Throat, Cough, Hoarseness
- Trial name
- NCT07849322
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Samsun University
Tympanoplasty Surgery
Partial Thickness vs Full Thickness Tragal Cartilage Grafts in Endoscopic Type 1 Tympanoplasty
Primary Objective: Compare 6-month graft success rates between 0.5 mm sliced and 1.8 mm full-thickness tragal cartilage grafts.(3) H1: Sliced cartilage yields ≥90% success versus ≤80% for full-thickness.(3) H0: No difference…
- Trial name
- NCT07471191
- Testing
- endoscope
- Volunteers
- 30 people
- Sponsor
- Assiut University
Eustachian Tube Dysfunction
Correlation Analysis Between ETF and Prognosis of Tympanoplasty
The regular opening of the eustachian tube plays an important role in maintaining normal pressure in middle ear cavity, hearing function and preventing the occurrence of middle ear inflammation.
- Trial name
- NCT03424369
- Testing
- Tympanoplasty
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Perforated Eardrum
Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty
This study aims to prospectively compare surgical field quality and intraoperative blood loss between general inhalational anesthesia to total intravenous anesthesia (TIVA) alone in subjects undergoing endoscopic ear surgery.
- Trial name
- TIVA (NCT05993039)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product, Propofol injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Our Lady of the Lake Hospital
Tympanic Membrane Perforation, Tympanoplasty
Comparison of Results of Myringoplasty Using Biodesign - an Otologic Graft Made From Porcine Small Intestinal Submucosa, Temporalis Fascia, or Tragal Perichondrium - a Retrospective Cohort Analysis
The goal of this observational, retrospective study is to learn whether a ready-made graft patch (Biodesign, made from porcine small intestinal submucosa) works as well as a participant's own tissue graft (such as tragal…
- Conditions
- Tympanic Membrane Perforation, Tympanoplasty, Myringoplasty
- Trial name
- Biodesign (NCT07698171)
- Testing
- tympanoplasty using Biodesign, tympanoplasty using autologous tissue graft
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Wolfson Medical Center
Tympanoplasty Surgery, Laryngeal Mask Airway
Comparative of Video Laryngeal Mask and Endotracheal Intubation in Patients Undergoing Tympanoplasty Surgery.
The effects of video laryngeal mask and endotracheal intubation on hemodynamic parameters and the development of postoperative respiratory complications in participants scheduled for tympanoplasty will be evaluated.
- Trial name
- NCT07084636
- Testing
- Video Laryngeal Mask, Endotracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Samsun University
Tympanic Membrane Perforation
Use of Biodesign® Otologic Graft in Tympanoplasty
This is a prospective, randomized trial to evaluate tympanoplasty outcomes using Biodesign SIS graft compared to autologous temporalis fascia, the most commonly used graft for repair of tympanic membrane.
- Trial name
- NCT03904316
- Testing
- Biodesign Otologic graft, Autologous temporalis fascia
- Where
- United States
- Sponsor
- Henry Ford Health System
Tympanoplasty Surgery
Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery
Little innovation in the material used for middle ear packing has occurred over the past decade, despite the fact that animal models have shown increased acute inflammation and increased fibrosis in the long term histologically.
- Trial name
- NCT04783233
- Testing
- Chitosan succinamide, Gelfoam
- Where
- United States
- Sponsor
- Henry Ford Health System
Tympanic Membrane Perforation
Hearing Results and Post Surgical Outcomes Using Amniotic Membrane Allograft vs. Fascia for Tympanoplasty
The trial seeks to provide evidence that the Skye ActiveBarrier provides similar surgical and functional outcomes as fascia when used for tympanoplasties while offering benefits including reduced operative time, better patient…
- Trial name
- NCT03028272
- Testing
- Skye Barrier, Fascia
- Sponsor
- University of Missouri-Columbia
Tympanoplasty, Myringoplasty
NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison
This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing…
- Conditions
- Tympanoplasty, Myringoplasty, Neutrophil-to-Lymphocyte Ratio, Low-flow Anesthesia
- Trial name
- ANFLUX (NCT07064642)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Eda KAZANÇ ÖZDEN
Otitis Media, Suppurative, Tympanic Membrane Perforation
Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing.
Throughout history, honey has been recognized for its healing properties. The use of honey for its medicinal properties dates back to 2200 BCE.
- Trial name
- NCT05605262
- Testing
- Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Tympanic Membrane Perforation
Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil"
Eligible participants with chronic tympanic membrane perforation (>6 month) will be given a detailed description and offered to participate in the study.
- Trial name
- NCT06542367
- Testing
- Tympanoplasty performed under local anesthesia using fat graft and "Tachosil".
- Volunteers
- 20 people
- Sponsor
- HaEmek Medical Center, Israel
Chronic Otitis Media, Tympanic Membrane Perforation
Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty
Chronic otitis media is a long-term ear infection that may cause a hole in the eardrum, leading to repeated ear discharge and hearing loss.
- Conditions
- Chronic Otitis Media, Tympanic Membrane Perforation, Conductive Hearing Loss
- Trial name
- NCT07149480
- Testing
- Underlay Tympanoplasty, Interlay Tympanoplasty
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Sore-throat, Anxiety
The Effect Of Preoperative Anxiety Level On Postoperative SoreThroat
Tympanoplasty is the general name given to operations in which the defect in the tympanic membrane is repaired with a connective tissue graft to correct the pathology in chronic otitis media and its sequelae.
- Trial name
- NCT06191783
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Balikesir University
Cholesteatoma
Endoscopic Transcanal Tympanoplasty With Attico-antrostomy Versus Endoscopic-assisted Canal Wall up Mastoidectomy in Management of Localized Cholesteatoma: A Randomized Clinical Trial
the main objective of the study is to compare endoscopic transcanal tympanoplasty with attico-antrostomy with endoscopic assisted canal wall up mastoidectomy in treatment of limited attic cholesteatoma.
- Trial name
- NCT04959539
- Testing
- endoscopic transcanal tympanoplasty with attico-antrostomy, endoscopic assisted canal wall up mastoidectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Tympanic Membrane Perforation
Evaluation of Prognostic Factors in Tympanoplasty
Tympanoplasty is the surgical operation performed for the reconstruction of the eardrum and/or the ossicles. Tympanoplasty is classified into five different types, originally described by Horst Ludwig Wullstein.
- Trial name
- NCT03416725
- Testing
- Otoscope
- Volunteers
- 70 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Otitis Media
Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?
Large tympanic membrane (eardrum) perforations present a surgical challenge and are historically associated with lower graft take rates compared to smaller perforations.
- Conditions
- Tympanic Membrane Perforation, Otitis Media, Suppurative Otitis Media, Chronic Suppurative Otitis Media
- Trial name
- NCT07834892
- Testing
- Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty
- Volunteers
- 50 people
- Sponsor
- Assiut University