Clinical trials: Type 2 Diabetes
Type 2 Diabetes, HbA1c
Daily Protein Pacing Effects on HbA1c in Type 2 Diabetics
This study will examine the effects of protein (whey) supplementation added to the normal diet of pre-diabetes or diagnosed type 2 diabetes mellitus (T2DM) men and women on plasma glycated hemoglobin (HbA1c) and total body fat…
- Conditions
- Type 2 Diabetes, HbA1c, Protein Intake
- Trial name
- NCT05355090
- Testing
- PP
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Diabetes Mellitus, Non-Insulin-Dependent
NNC 90-1170 Mechanism of Action: A Double-Blind, Randomized, Single-Center, Placebo-Controlled, Crossover Study to Examine Beta-Cell Responsiveness to Graded Glucose Infusion in Subjects With Type 2 Diabetes
The purpose of this research study is to investigate the mechanism of action of a new investigational medication (drug), NNC 90-1170, which is being developed for the treatment of type 2 diabetes (adult onset type of diabetes.
- Trial name
- NCT00013910
- Testing
- NNC 90-1170
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Polyneuropathies, Diabetic Complications Neurological
Is Serum Irisin Level a Biomarker in Diabetic Polyneuropathy?
Diabetic polyneuropathy is a common complication of type 2 diabetes mellitus associated with sensory impairment and functional disability. Irisin is a myokine that has been implicated in glucose metabolism and neuroprotection.
- Conditions
- Polyneuropathies, Diabetic Complications Neurological, Diabetes Mellitus Type 2
- Trial name
- NCT07734597
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- GÜLDEN ANATACA
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Primary Disease: 1. Type 2 Diabetes
Culinary Medicine vs. Nutrition Education in Diabetes
This pragmatic trial compares the effectiveness of virtual culinary medicine classes vs. standard of care medical nutrition visits to improve glycemic control in patients with uncontrolled type 2 diabetes .
- Trial name
- NCT05019274
- Testing
- Culinary Medicine Intervention, Standard of Care Nutrition Visits
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Healthy People, Diabetes Mellitus, Type 2
The Effects of Mixed Grain on Blood Glucose and Insulin in Healthy Male
This study was an open, 4-treatment, 5-sequence, 5-day cross-over randomized design clinical trial to evaluate the efficacy of mixed grain on blood glucose, insulin and Glycemic index(GI) in healthy males.
- Trial name
- NCT01840982
- Testing
- Mixed grain 1, Mixed grain 2, White rice
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Type 2 Diabetes
Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota
Accumulating evidence suggests that bile acids and bacteria in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis.
- Trial name
- NCT02061124
- Testing
- Sevelamer 1600 mg TID for 7 days
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide
Many patients with type 2 diabetes also have conditions that are treated with diuretics. The patients may also be treated with GSK189075 for their diabetes.
- Trial name
- NCT00671424
- Testing
- Hydrochlorothiazide (HCTZ), Remogliflozin etabonate (GSK189075), Furosemide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabete Type 2, Pre Diabetes
Investigation of PJ vs. Sugar on Glucose Levels in Healthy and Prediabetic Subjects
Pomegranate fruits and products, including juice, tea, wine and extracts are widely consumed and recognized for their health benefits.
- Trial name
- PSW (NCT04591782)
- Testing
- PomJuice, Water, Sugar Water
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity, Adiposity
GIP/GLP-1 Co-Activity in Subjects With Obesity: Lowering of Food Intake
We aim to delineate the effects of separate and combined infusion of GIP and GLP-1 on food intake, appetite, bone health and fat metabolism in overweight/obese subjects.
- Conditions
- Obesity, Adiposity, Type 2 Diabetes
- Trial name
- GASOLIN (NCT02598791)
- Testing
- IIGI+GIP, IIGI+GLP-1, OGTT
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2
OXEMET™ 1000 mg Coated Tablets (Metformin Hydrochloride) Bioequivalence Study. OXEMET (TM) is a Trademark of the GlaxoSmithKline Group of Companies. GLAFORNIL(TM) is a Trademark of Merck.
This is an open-label, single-center, randomized, 2-way crossover study to evaluate the bioequivalence of OXEMET™ 1000 mg coated tablets, relative to 1000 mg of the reference product administered as two 500 mg tablets, under…
- Trial name
- NCT01842620
- Testing
- Metformin
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus With Periodontal Disease
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus doxycycline on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02845024
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Diabetes Mellitus, Type 2 Diabetes Mellitus
Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)
This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes, and controls without diabetes.
- Trial name
- NCT01172743
- Where
- Qatar
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Type II Diabetes Mellitus
Pharmacokinetics and Safety/Tolerability Profile of CKD-379
A study to compare the pharmacokinetics and safety/tolerability between CKD-379 tablet and D759, D745, D150 combination
- Trial name
- NCT05452525
- Testing
- CKD-379 I, CKD-379 II, D759+D745+D150
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type 2 Diabetes
Point of Care HbA1c as a Screening Test for Type 2 Diabetes in First Nations
1. Purpose to estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in a BC First Nation community to determine the utility of community based screening by examining how many positively screened people follow…
- Trial name
- NCT01333176
- Testing
- Point-of-care "finger-poke" HbA1c determination., HbA1c blood test, HbA1c finger poke test
- Where
- Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 2 Diabetes Mellitus
Absolute Bioavailability Study With Bexagliflozin
The purpose of this study is to determine the absolute bioavailability of bexagliflozin following a single oral dose co-administered with an intravenous dose.
- Trial name
- NCT03417076
- Testing
- Bexagliflozin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Theracos
NIDDM
Spices Inhibit the Formation and Absorption of Malondialdehyde From Hamburger Meat
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01027052
- Testing
- Hamburger meat patty with salt, Hamburger meat patty with spice blend
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes
Effect of the Digital Livsstilsverktyget in Conjunction With a Large Language Model on the Prevention of Type 2 Diabetes
The overall aim of the study is to investigate the incidence of type 2 diabetes in individuals who have access to a digital intervention tool as compared with randomized controls during three years.
- Trial name
- NCT07659535
- Testing
- Lifestyle tool
- Where
- Sweden
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Diabetes Mellitus, Type 2, Endoplasmic Reticulum Stress
Role of Endoplasmic Reticulum Stress in the Pathophysiology of Type 2 Diabetes
The purpose of this study is to investigate whether Endoplasmic Reticulum (ER) stress pathway is activated in peripheral tissues (adipose tissue) in insulin resistant diabetic patients compared to healthy subjects normoglycemic…
- Trial name
- GLUCOSTRESS (NCT02368704)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Diabetes Mellitus, Type 2
Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes
The experimental approach in this study intends to investigate the role of hepatic glycogen content on nocturnal regulation of endogenous glucose production including the relative contributions of glycogenolysis and…
- Trial name
- NCT04416204
- Testing
- glycogen loading, No Glycogen Loading
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
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