Clinical trials: Type 2 Diabetes (Adult Onset)
Obesity & Overweight, Type 2 Diabetes
Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy
This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy.
- Conditions
- Obesity & Overweight, Type 2 Diabetes, Type 2 Diabetes (Adult Onset), Obesity Type 2 Diabetes Mellitus
- Trial name
- NCT07641361
- Testing
- Hydration Plus, Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Obesity, Diabetes Mellitus, Type 2
A Study of the Safety and Efficacy of Topiramate in the Treatment of Obese, Type 2 Diabetes Patients on a Controlled Diet
The purpose of this study is to determine the efficacy and safety of topiramate compared with placebo in obese, Type 2 diabetic patients on a controlled diet.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00231530
- Testing
- topiramate
- Volunteers
- 541 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)
The purpose of this study is to determine the key factors influencing insulin sensitivity in type 1 diabetes (T1DM) and maturity onset diabetes of the young, type 2 (MODY2).
- Conditions
- Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2, MODY2, Insulin Resistance
- Trial name
- NCT02971202
- Testing
- Hyperinsulinemic, euglycemic clamp, 20% dextrose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type II
Effect of Liraglutide (Victoza) on Inflammation in Human Adipose Tissue and Blood
The objective of this study is to test the hypothesis that liraglutide (commonly known as Victoza) can promote an anti-inflammatory macrophage phenotype in human adipose tissue and blood, thereby reducing localized and systemic…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type II, Diabetes Mellitus, Adult-Onset, Inflammation
- Trial name
- NCT02650206
- Testing
- Victoza (liraglutide) with dietician monitoring
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Stanford University
Diabetes Mellitus, Adult Onset
Effect of Cinnamon on Glucose and Lipid Levels in Non-Insulin Dependent Type 2 Diabetes Mellitus
The purpose of this study is to determine the effects of cinnamon on serum glucose and lipid levels in people with non-insulin dependent type 2 diabetes mellitus.
- Trial name
- NCT00237640
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Oklahoma
Diabetes Mellitus Type 2, Adult-onset Diabetes
Automated SMS-Based Appointment Validation Tool
Medic Mobile conceptualized and proposed the creation of an SMS-based appointment validation tool to automate appointment confirmation and rescheduling.
- Trial name
- NCT01671189
- Testing
- SMS Reminder Software Tool
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medic Mobile
Diabetes Mellitus, Type 1, Diabete Type 2
Mapping Diabetes in Quebec: Validating Medico-administrative Algorithms for Type 1 Diabetes, Type 2 Diabetes and LADA
The goal of this observational study is to validate medico-administrative algorithms that classify diabetes phenotypes (Type 1, Type 2, and Latent Autoimmune Diabetes in Adults - LADA) in a population-based cohort in Quebec…
- Conditions
- Diabetes Mellitus, Type 1, Diabete Type 2, Diabetes;Adult Onset, Diabetes, Autoimmune
- Trial name
- VDA (NCT06573905)
- Testing
- no intervention
- Where
- Canada
- Volunteers
- 17,271 people
- Sponsor
- Universite du Quebec en Outaouais
Fatty Liver
The Effect of a Probiotic on Hepatic Steatosis
Non-alcoholic fatty liver disease (NAFLD) is an accumulation of fat and fibrous tissue in the liver. It is the most common cause of chronic liver disease in the United States.
- Trial name
- NCT00099723
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VSL Pharmaceuticals
Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
Technology Intensified Diabetes Education Study in African Americans
The purpose of this study is to test the usefulness of an intervention that combines technology with diabetes education and skills training.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Noninsulin Dependent
- Trial name
- TIDES (NCT02088658)
- Testing
- Technology Intensified
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- State University of New York at Buffalo
Diabetes, Diabetes Mellitus, Type 2
Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes
The study compares 2 medicines for type 2 diabetes: fast-acting insulin aspart (a new medicine) and NovoRapid®/NovoLog® (a medicine doctors can already prescribe).
- Trial name
- onset 9 (NCT03268005)
- Testing
- Faster-acting insulin aspart, Insulin aspart, Insulin degludec
- Where
- 167 sites in United States, Argentina and 16 more
- Volunteers
- 1,264 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus (T2DM)
Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients
The purpose of this study was to assess the efficacy and safety of vildagliptin 50 mg bid add-on therapy to improve overall glycemic control in patients with T2DM inadequately controlled by insulin, with or without concomitant…
- Trial name
- NCT02002221
- Testing
- Vildagliptin (LAF237), Insulin, Metformin
- Where
- 31 sites in Japan
- Volunteers
- 156 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Adult-Onset
Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation
New onset diabetes after renal transplantation (NODAT) is a common and severe complication negatively influencing graft and patient survival. Cyclosporine (CsA) and Tacrolimus are the basis of modern immunosuppression.
- Trial name
- 01-DMPT (NCT01002339)
- Testing
- Tacrolimus with rapid steroid withdrawal, Tacrolimus with steroids minimization, CsA with steroid minimization
- Where
- 10 sites in Spain
- Volunteers
- 134 people
- Sponsor
- Armando Torres Ramírez
Diabetes, Autoimmune, Diabetes Mellitus, Adult-Onset
Early Insulin Treatment in Patients With Latent Autoimmune Diabetes
Among adult patients diagnosed with type 2 diabetes, about 6% have autoantibodies directed against the insulin producing beta cells in the pancreas.
- Trial name
- NCT01109927
- Testing
- Insulin
- Volunteers
- 42 people
- Sponsor
- Lund University Hospital
Type 2 Diabetes Mellitus, Secondary Hypogonadism
Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes Mellitus
The purpose of this study is to determine the effect the investigative drug has on glycemic control in men with type 2 diabetes mellitus (T2DM) and secondary hypogonadism
- Trial name
- NCT01191320
- Testing
- Androxal
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- Repros Therapeutics Inc.
Type 1 Diabetes Mellitus
The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
The primary purpose of this protocol is to assess the efficacy, tolerability, and safety of MGA031 when administered according to 3 different MGA031 dosing regimens in children and adults with recent-onset (diagnosis within past…
- Trial name
- NCT00385697
- Testing
- Teplizumab
- Where
- 115 sites in United States, Canada and 14 more
- Volunteers
- 554 people
- Sponsor
- MacroGenics
Type 1 Diabetes, Type 1 Diabetes Mellitus Maturity Onset
Evaluating ImmuNe Changes in the Evolution of Pre Type 1 Diabetes With Adult ONset
Little is known about how type 1 diabetes or coeliac disease develop in adults. Studies following children at risk of type 1 diabetes from birth have shown that the marker of type 1 diabetes autoimmunity (antibodies against the…
- Trial name
- INCEPTiON (NCT06006468)
- Testing
- High genetic risk for type 1 diabetes, High gentic risk for Coeliac disease
- Where
- United Kingdom
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Obesity, Diabetes Mellitus, Type 2
A Study of the Safety and Effectiveness of Topiramate on Insulin Sensitivity in Overweight or Obese Patients With Type 2 Diabetes
The purpose of this study is to investigate (1) the effect of topiramate on insulin sensitivity in overweight or obese patients with type 2 diabetes mellitus and (2) the safety of topiramate in type 2 diabetic patients.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00236626
- Testing
- topiramate
- Volunteers
- 38 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes Mellitus, Type 2 Diabetes Mellitus
Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)
This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes, and controls without diabetes.
- Trial name
- NCT01172743
- Where
- Qatar
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes
The purpose of this study is to switch from insulin to oral sulfonylurea in patients with apparent type 1 diabetes or maturity onset diabetes in the young that are insulin treated.
- Conditions
- Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1, Childhood Diabetes Mellitus, Insulin-dependent Diabetes Mellitus
- Trial name
- SUtoChildT1D (NCT04239586)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital
Type 2 Diabetes (Adult Onset)
Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
The primary purpose of this study is to evaluate the efficacy, durability, and mechanism of HbA1c reduction produced by the combination of pioglitazone plus tirzepatide compared to metformin plus sitagliptin in patients with…
- Trial name
- NCT06246799
- Testing
- Tirzepatide, Pioglitazone, Sitagliptin
- Where
- 2 sites in United States
- Volunteers
- 256 people
- Sponsor
- The University of Texas Health Science Center at San Antonio