Clinical trials: Type 2 Diabetes Mellitus (DM)
Diabete Mellitus, T2 Diabetes and Fatty Liver Disease (Non-alcoholic Origin)
Duodenal pulsENDO as an Early Treatment for Type 2 DM
This study is designed to evaluate the efficacy and safety of endoscopic duodenal re-cellularization therapy using pulsed electric field in individuals with in patients with a recent diagnosis of type 2 diabetes mellitus (T2DM).
- Trial name
- DREAM-1 (NCT07376486)
- Testing
- pulsENDO treatment
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus (T2DM)
Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients
The purpose of this study was to assess the efficacy and safety of vildagliptin 50 mg bid add-on therapy to improve overall glycemic control in patients with T2DM inadequately controlled by insulin, with or without concomitant…
- Trial name
- NCT02002221
- Testing
- Vildagliptin (LAF237), Insulin, Metformin
- Where
- 31 sites in Japan
- Volunteers
- 156 people
- Sponsor
- Novartis Pharmaceuticals
Type-II Diabetes
Postbiotic MBS and Metformin Combination in Patients With T2DM
The primary objective is to evaluate the effect of MBS treatment in human subjects, and to validate its impact on intestinal flora and diabetes symptoms on diabetic patients undertaking metformin.
- Trial name
- NCT04639492
- Testing
- MBS oral solution
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- Microbio Co Ltd
Diabetes Mellitus, Type II
Mechanisms of Glycemic Improvement After Gastrointestinal Surgery
This study is designed as a prospective clinical trial aimed at investigating the mechanisms behind observed improvements in type 2 diabetes mellitus (T2DM) following bariatric surgery.
- Trial name
- NCT01025999
- Testing
- No intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Hypertension
Hypertensive Treatment Pattern Survey for Type II Diabetes Mellitus Patients With Complication and Hypertension
This study will address the treatment rate and control rate of hypertension, treatment pattern and factors to affect blood pressure control by examining (retrospective) medical records of Type II DM patients with DM related…
- Trial name
- CRYSTAL-CO (NCT00771069)
- Where
- 13 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Obesity, Diabetes Mellitus
Progression of Diabetic Retinopathy Post Bariatric Surgery (BS)
Studies conducted assessing diabetic eye disease have shown a progression of diabetic retinopathy with rapid improvement of glycemic control during pregnancy and in patients with type 1 diabetes.
- Trial name
- NCT01393873
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus, Type 2
MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men
The study is a randomized control trial involving 100 participants (formerly incarcerated Black men with poorly controlled diabetes) to examine the effect of a tailored nurse case manager on glycemic control and other clinical…
- Trial name
- MANAGe-DM (NCT06031428)
- Testing
- MANAGe-DM - novel nurse case management, Monthly Educational Mailing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medical College of Wisconsin
Palliative Care, Diabetes Mellitus, Type 2
GLYPALCARE STUDY - Multicenter, Randomized Study for Evaluating Continuous Glucose Monitoring (CGM) by Using FreeStyle Libre 2 (FSL2) for Preventing Hyperglycemia/Hypoglycemia Crisis in Advanced Oncological Patients.
Cancer patients with known or newly diagnosed (i.e. iatrogenic) Diabetes Mellitus (DM) in Palliative/Supportive Care will be enrolled. Patients will be randomly assigned to one of two groups.
- Conditions
- Palliative Care, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Diabetes
- Trial name
- NCT04942756
- Testing
- Continuous Glucose Monitoring, Standard Care
- Where
- 6 sites in Israel, Italy and 1 more
- Volunteers
- 118 people
- Sponsor
- Antea Foundation
Diabetes Mellitus, Type 2
DM-BOOST Para Latinx: a Diabetes Mellitus Program Using Behavioral Economics to Optimize Outreach and Self-management Support With Technology for Latinx Patients
The specific aims of this project are to culturally adapt the DM-BOOST intervention for Latinx patients, usability test 'DM-BOOST para Latinx' to optimize cultural appropriateness and patient engagement and conduct a feasibility…
- Trial name
- NCT05583877
- Testing
- Diabetes BOOST, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Daniel Amante
Chronic Kidney Disease(CKD), Type 2 DM
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)
IRIS-CKD is an implementation study to improve guideline-recommended screening of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
- Conditions
- Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- IRIS-CKD (NCT06906627)
- Testing
- (IRIS-CKD Screening Program): Home Kit, (IRIS-CKD Screening Program): Standard Lab Order
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Ischemic Stroke, Diabete Mellitus
DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes
Post-stroke cognitive impairment (PSCI) increases the risk of disability and mortality in stroke patients, thereby exacerbating the disease burden of stroke.
- Trial name
- NCT07241897
- Testing
- Sentagliptin Phosphate - single dose
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Diabetes Mellitus Type 2, Metformin
Variation in Serum Levels of Metformin in Patients With Reduced Renal Function
Metformin is widely used for treatment of type 2 diabetes mellitus. Side-effects are few and mainly from the gastrointestinal tract.
- Conditions
- Diabetes Mellitus Type 2, Metformin, Pharmacokinetics
- Trial name
- NCT00767351
- Volunteers
- 30 people
- Sponsor
- Skane University Hospital
Smoking
Brief Intervention to Promote Smoking Cessation in DM Smokers
The study is a randomized controlled trial (RCT) on a tailored smoking cessation intervention targeted type 2 diabetic patients who smoke (DM intervention). The objectives are: 1.
- Trial name
- NCT02875782
- Testing
- Smoking cessation and DM specific component intervention, Control group
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Diabetes, Diabetes (DM)
Voice-activated and Touchscreen-controlled Smart Speaker Intervention for Older Adults With Poorly Controlled Type 2 Diabetes
This is a pre-post pilot study that will test the feasibility and acceptability of a health educator delivered diabetes education and skills training intervention using a voice-activated, touch screen controlled, smart speaker.
- Conditions
- Diabetes, Diabetes (DM), Type 2 Diabetes
- Trial name
- VATC-SS (NCT07734259)
- Testing
- VATC-SS Intervention
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Type 2 Diabetes Mellitus
The Effects of Insulin Detemir and Gliclazide-MR Treatments on Endothelial Functions in Patients With Type 2 Diabetes
The main purpose of this study is to analyze the effects of the addition of sulfonylurea (gliclazide MR) or ,alternatively, basal insulin (insulin detemir) to life-style modification and metformin treatment as a second step…
- Trial name
- NCT01420692
- Testing
- Gliclazide MR, Insulin Detemir
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara University
Diabetes Mellitus, Type 2 DM
Safety and Efficacy Assessment of Unani Formulation 'Dolabi' in Management of Diabetes Mellitus Type II
Diabetes is a chronic health condition that affects millions of people worldwide. In recent years, Pakistan has witnessed a significant increase in the prevalence of diabetes, making it a major public health concern.
- Trial name
- NCT06841497
- Testing
- Dolabi
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Hamdard University
Diabetes Mellitus, Type 2
Pilot for the Analysis of Usability in the Use of the Diacare Platform for People With Type 2 DM and Their Professionals
The objective of this study is to evaluate the usability, utility and feasibility of the Diacare platform and the ability of users to use the platform and receive valuable information from it to help address the management of…
- Trial name
- NCT04244110
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Diabetes Mellitus, Type 2
Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships
The goal of this study is to develop, implement, and evaluate a patient-centered triage and referral model designed to improve health outcomes for individuals with uncontrolled type 2 diabetes mellitus (T2DM) and unmet…
- Trial name
- THRIVE-DM (NCT07043426)
- Testing
- THRIVE-DM, Standard of care
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Boston Medical Center
Diabetes Mellitus, Type 2, Insulin Response
Effects of TUDCA on Endothelial Function in Type 2 DM
The pilot study is designed to investigate the acute and chronic effects of the diet supplement tauroursodeoxycholic acid (TUDCA) on endothelial function in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Response, Endothelial Dysfunction
- Trial name
- NCT03462940
- Testing
- Tauroursodeoxycholic acid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Non Insulin Dependent Diabetes Mellitus
Prospective Observatonal Study for Effect of Duodenojejunal Bypass and Gastric Bypass on T2DM Patients
Surgical treatment for type 2 diabetes has been taken note especially in less obese or non obese patients. In Asian, the nuber of less obses or non obese patients with T2DM is greater than that of the obese.
- Trial name
- T2DM (NCT01735253)
- Testing
- laparoscopic roux en Y gastric bypass / open duodenojejunal bypass
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Inha University Hospital