Clinical trials: Type 2 Diabetes Mellitus Remission
Newly Diagnosed Type 2 Diabetes
Managing DIabetes Remission After Combined Therapy in EarLy Stage of DiabetEs
Epidemiologic, social and economic burdens of type 2 diabetes mellitus (T2DM) keep rising worldwide. Implementation of T2DM preventive trategies is lagging behind.
- Trial name
- MIRACLE (NCT04271189)
- Testing
- Metformin-Sitagliptin-Empaglifozin-Pioglitazone, Standard of care
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Type 2 Diabetes, Obesity, Morbid
Remission of Type 2 Diabetes Via Calorie Restriction
The primary purpose was to evaluate the efficacy of Korean low-calorie diet for obese adult patients with type 2 diabetes with a body mass index of 25 kg/m2 or higher.
- Trial name
- K-Direct1 (NCT05754775)
- Testing
- Calorie restriction via total food replacement
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Yeouido St. Mary's Hospital
Type 2 Diabetes Mellitus Remission
Type 2 Diabetes Remission
The study aims to establish a cohort of patients with type 2 diabetes (T2D) who have achieved remission through lifestyle intervention or bariatric surgery.
- Trial name
- NCT06177210
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Diabetes Mellitus, Type 2
Digital, Blended Lifestyle Intervention for Type 2 Diabetes Remission
410 Dutch type 2 diabetes patients will be randomized using a 5:1 ratio to intervention group versus control, to a lifestyle intervention program given via a mobile application and digital platform.
- Trial name
- IBIDEM (NCT05346614)
- Testing
- Lifestyle intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 410 people
- Sponsor
- Ancora Health B.V.
Type 2 Diabetes Mellitus, Obesity
Low-Calorie Diets on Type 2 Diabetes Remission
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing rapidly in China. China currently has ~130 million diabetes cases, and over 90% are T2DM.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Overweight
- Trial name
- NCT05472272
- Testing
- Formula diet, Food-based diet
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Type 2 Diabetes Mellitus
Remission Rates of New Type 2 Diabetes With Weight Loss and Exercise
This is a study of the effects of weight loss and exercise training on glucose control as measured by the Hemoglobin A 1 C in individuals with recently diagnosed Type 2 Diabetes. Study outcomes are measured at 6 months.
- Trial name
- Resolution (NCT02065544)
- Testing
- behavioral weight loss and exercise
- Volunteers
- 12 people
- Sponsor
- University of Vermont
Type 2 Diabetes
The eHealth Diabetes Remission Trial - Pilot Study
Ten study participants will consume a low-calorie total diet replacement for 12 weeks, have a 6-week food reintroduction phase (week 13-18) and continue with the weight loss maintenance phase until the end of the study (week…
- Trial name
- eDIT-pilot (NCT04805996)
- Testing
- Diabetes remission using total diet replacement and eHealth contact with the healthcare provider
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Julia Otten
Morbid Obesity, Type2 Diabetes
Elucidating the Mechanism of Remission of Type 2 Diabetes in Morbid Obese Patients After Bariatric Surgery
The main aim of this study is to elucidate the mechanism of the remission of type 2 diabetes in the morbid obese patients after laparoscopic sleeve gastrectomy.
- Trial name
- NCT03038373
- Testing
- Laparoscopic Sleeve Gastrectomy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dasman Diabetes Institute
Diabetes Mellitus, Type 2
DiaMester Pilot RCT: E-health Lifestyle Program for Type 2 Diabetes
This registration covers a pilot for a 3-armed parallel-group randomized controlled trial (RCT) that will evaluate the efficacy of DiaMester, a Norwegian e-health programme designed to improve self-management and induce…
- Trial name
- DiaMester (NCT07361640)
- Testing
- e-health lifestyle program, Low calorie diet
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Oslo University Hospital
Type 2 Diabetes Mellitus, Obesity
Fasting-Associated Immune-metabolic Remission of Diabetes
People with a body mass index above 28 kg/m² and an onset of type 2 diabetes within the last 4 years had a remission (HbA1c <6.5% without medication) of diabetes in over 80% upon weight loss of 15 kg.
- Trial name
- FAIR (NCT05295160)
- Testing
- weight loss by very low energy diet intake which may differ in protein or carbohydrate content
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Charite University, Berlin, Germany
Type 2 Diabetes
Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)
This study focuses on identifying potentially predictive human circulating adipocyte and muscle biomarkers of diabetes remission after bariatric surgery in obese type 2 diabetic (T2D) subjects.
- Trial name
- BARIAKINES (NCT05472883)
- Testing
- blood samples, collection of body tissues, routine care procedure
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Toulouse
Type 2 Diabetes Mellitus in Remission, Metabolic Associated Fatty Liver Disease
Prevalence of MAFLD in Patients With Type 2 Diabetes in Jiangsu Province of China
In 2019, the number of patients with diabetes was about 463 million in the world, accounting for 8.3% of the total population, and it is expected to rise to 578 million (9.2%) by 2030 and 700 million (9.6%) by 2045.
- Trial name
- NCT05597709
- Testing
- Ultrasound attenuation parameter measurement, fasting blood glucose and fasting insulin determination
- Where
- China
- Volunteers
- 2,900 people
- Sponsor
- Wuxi Hisky Medical Technology Co Ltd
Type 2 Diabetes
Remission of Type 2 Diabetes With Dapagliflozin (READ Trial)
This is a multicenter, randomized, double-blind, placebo-controlled study to assess the effect of dapagliflozin add-on intensive lifestyle intervention for remission of type 2 diabetes in obese patients with Type 2 Diabetes…
- Trial name
- READ (NCT04004793)
- Testing
- Intensive lifestyle intervention, Dapagliflozin 10 MG Oral Tablet
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Shanghai Zhongshan Hospital
Severe Obesity, Diabetes Mellitus, Type 2
Diabetes Remission and Hypoabsorptive Bariatric Surgery
Bariatric surgery is the most effective treatment to achieve type 2 Diabetes Mellitus (DM) remission in patients with severe obesity.
- Conditions
- Severe Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
- Trial name
- DIABAR-3 (NCT06043245)
- Testing
- Duodenal Switch, SADI-S, Minigastric Bypass
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Universitari de Bellvitge
Diabetes Mellitus Type 2, Obese Diabetics
Remission of Type 2 Diabetes With Lifestyle Intervention
The goal of this clinical trial is to achieve diabetes type 2 (DM2) remission using intensive lifestyle intervention. The main questions it aims to answer are: Does intensive lifestyle intervention (including Mediterranean diet…
- Trial name
- REMeDI2ME (NCT07017127)
- Testing
- Mediterranean diet, Physical activity intervention, Psychological intervention
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University of Split, School of Medicine
Type 2 Diabetes
DiEt ChoIce to Promote Type 2 Diabetes rEmission
Type 2 diabetes is typically viewed as a chronic, progressive, and lifelong condition. Patients and their healthcare providers "manage" type 2 diabetes through lifestyle modifications and various types of medications designed to…
- Trial name
- DECIDE (NCT05710900)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Diabetes Mellitus, Type 2, Obesity
Effectiveness of a Weight Management Programme on Diabetes Remission in Obese Patients With Early Diabetes
The goal of this clinical trial is to determine the effectiveness of a weight management programme in primary care in achieving diabetes remission in obese patients with early diabetes.
- Trial name
- NCT05762120
- Testing
- Weight Management Programme
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- National Healthcare Group Polyclinics
Type2 Diabetes, Complication of Bariatric Procedure
Efficacy and Safety of One-anastomosis Versus Roux-en-Y Gastric Bypass for Type 2 Diabetes Remission
Diabetes mellitus (T2DM) is the most common complication of obesity patients. According to previous literature reports, weight loss and metabolic surgery are powerful means to treat obesity complicated with T2DM.
- Trial name
- ORDER (NCT05015283)
- Testing
- The laparoscopic One-anastomosis gastric bypass will consist of:, The laparoscopic Roux-en-Y gastric bypass will consist of:
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Beijing Friendship Hospital
Diabetes Mellitus Type 2
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.
- Trial name
- CB5 (NCT05934409)
- Testing
- Bariatric surgery, Nicotinic Acid
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes Mellitus
The Progress of Diabetes After Supaglutide Treatment in Type 2 Diabetes Patients
Glucagon like peptide-1 receptor agonist (GLP-1RA) can enhance insulin secretion and inhibit glucagon secretion in a glucose concentration dependent manner, delay gastric emptying, and reduce food intake through central appetite…
- Trial name
- NCT06605287
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University