Clinical trials: Type 2 Diabetes Mellitus Remission
Diabetes Type 2, Obesity
Comparing High and Normal Protein Diets for the Dietary Remission of Type 2 Diabetes
The purpose of this study is to examine the impact of high protein (HP) vs. normal protein (NP) diets on weight loss, loss of fat free mass (FFM), and remission of type 2 diabetes (T2D) in individuals with T2D.
- Conditions
- Diabetes Type 2, Obesity, Diet Modification
- Trial name
- NCT03832933
- Testing
- High Protein Diet, Standard Protein Diet
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga
The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising Forxiga, metformin, basal insulin glargine and lifestyle approaches will be…
- Trial name
- NCT02561130
- Testing
- insulin glargine, metformin, Forxiga
- Where
- 7 sites in Canada
- Volunteers
- 154 people
- Sponsor
- Population Health Research Institute
Diabetes Mellitus, Type 2
A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese
The purpose of this study is to determine the effect of GLP-1 receptor agonist on inducing diabetes remission in newly diagnosed type 2 diabetes who are overweight or obese
- Trial name
- NCT03018665
- Testing
- Exenatide, BIAsp30, Metformin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Hospital of Jilin University
Type 2 Diabetes
The Effects of Glycemic Optimization Before Gastric Bypass Surgery
Metabolic surgery such as gastric bypass, gastric banding or sleeve gastrectomy operations can cause rapid and uncontrolled reductions in blood glucose.
- Trial name
- GLUCOSURG2 (NCT01353118)
- Testing
- gastric bypass
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Imperial College London
Pediatric Obesity, Type 2 Diabetes
Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
This is a multicentre, single-arm, feasibility study in adolescents with T2DM and obesity to investigate the recruitment and retention rates to a study using Low Energy Diets(LED).
- Trial name
- LEGEND (NCT06572345)
- Testing
- Low-energy diet, Qualitive interview - LED participants, Qualitive interview - Participants declining LED
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Obesity, Diabetes Mellitus, Type 2
Weight Management for the Remission of Type 2 Diabetes Using a Proprietary Meal Replacement System- Diabetes Remission Study (DRS)
A three month meal replacement dietary system which combines meal replacements and self-prepared meals which hypothetically will result in Diabetes remission in >30% of intervention subjects To assess the efficacy of which…
- Trial name
- DRS (NCT05397028)
- Testing
- Meal replacement system, Intensive lifestyle Intervention
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Type 2 Diabetes Mellitus
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)
The purpose of this pilot trial is to determine whether an intensive treatment with insulin glargine, metformin, acarbose and lifestyle can normalize blood glucose levels in patients with recently diagnosed type 2 diabetes…
- Trial name
- NCT01181674
- Testing
- insulin glargine, metformin, acarbose
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Population Health Research Institute
Type 2 Diabetes
Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Main Trial)
Type 2 diabetes mellitus is a chronic metabolic disorder characterized by progressive deterioration in the function of the pancreatic beta-cells, which are the cells that produce and secrete insulin (the hormone primarily…
- Trial name
- RESET-IT (NCT02192424)
- Testing
- Metformin alone, Metformin + Intermittent Insulin Therapy
- Where
- Canada
- Volunteers
- 109 people
- Sponsor
- Mount Sinai Hospital, Canada
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira
The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising IDegLira, metformin, and lifestyle approaches will be superior to standard diabetes…
- Trial name
- REMITiDegLira (NCT03862716)
- Testing
- IDegLira, insulin degludec, Metformin
- Where
- 8 sites in Canada
- Volunteers
- 159 people
- Sponsor
- Population Health Research Institute
Obesity, Diabetes Mellitus Type 2 in Obese
Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat)
The goal of this mechanistic study is to investigate the role of incretin hormones on weight loss-induced type 2 diabetes remission.
- Trial name
- DiabEATit (NCT06333132)
- Testing
- Weight loss-induced Diabetes Remission
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Diabetes Mellitus, Type 2
Effect of Whole Fruit on Glycemic Control in Adults With Type 2 Diabetes
Diabetes costs the U.S. healthcare system more than any other disease, and nearly half of Americans will develop either diabetes or prediabetes in their lifetime.
- Trial name
- NCT03758742
- Testing
- High-Fruit Diet
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2
The eHealth Diabetes Remission Trial
Overweight patients with type 2 diabetes are offered a total diet replacement with the goal of weight loss and diabetes remission.
- Trial name
- eDIT (NCT05491005)
- Testing
- Total diet replacement, eHealth, Face-to-face
- Where
- 3 sites in Sweden
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Umeå University
Type 2 Diabetes
A Feasibility Study of Optimal Non-Pharmacological Lifestyle Modifications in People With Type 2 Diabetes
The overall aim of this study is to examine the feasibility of a 12-month, two-arm lifestyle intervention to induce and maintain remission of type 2 diabetes (T2D).
- Trial name
- ON LiMiT (NCT07262788)
- Testing
- CH-rich diet with exercise, CH-reduced diet with exercise
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes Mellitus in Obese, Type 2 Diabetes
LCMD for Type 2 Diabetes Remission: Evaluation of Effectiveness and Exploration of Individual Differences
Type 2 diabetes (T2DM) has become a major public health problem. Achieving remission (HbA1c<6.5% without glucose-lowering medications) has recently become a new treatment goal.
- Trial name
- LCMD (NCT06442150)
- Testing
- Low-Calorie Medicine Diet, Low-Calorie Diet
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Diabetes Mellitus Type 2 in Obese
Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients.
In patients with type 2 diabetes, Roux-en-Y gastric bypass (RYGB), which excludes a portion of the stomach and the proximal intestine from the alimentary circuit, improves glucose metabolism more rapidly and more extensively than…
- Trial name
- PRECI-Surg (NCT03821636)
- Testing
- Standard Roux-en-Y gastric bypass, Long alimentary limb Roux-en-Y gastric bypass
- Where
- 4 sites in France
- Volunteers
- 396 people
- Sponsor
- University Hospital, Lille
MASLD, T2DM (Type 2 Diabetes Mellitus)
Non-Invasive MASLD Diagnosis & T2D Remission Biomarkers
The goal of this observational study is to prospectively develop and validate a non-invasive scoring system based on metabolic markers, proteomic, and transcriptomic profiles to accurately screen, diagnose, stage, and monitor…
- Conditions
- MASLD, T2DM (Type 2 Diabetes Mellitus), Non-alcoholic Fatty Liver Disease (NAFLD), Obesity
- Trial name
- ENSURE-MASLD (NCT07172997)
- Testing
- Bariatric Surgery
- Where
- 2 sites in Bahrain
- Volunteers
- 163 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Diabetes Mellitus, Type 2, Obesity
Calorie Reduction Or Surgery: Seeking Remission for Obesity And Diabetes
The escalating pandemics of obesity and type 2 diabetes mellitus (T2DM) are among the most significant contributors to morbidity and mortality worldwide.
- Trial name
- CROSSROADS (NCT01295229)
- Testing
- laparoscopic Roux-en-Y gastric bypass (RYGB) procedure, Lifestyle Intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Washington
Type 2 Diabetes, Morbid Obesity
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
The goal of this randomized clinical trial is to evaluate glycemic control in patients with morbid obesity and type 2 diabetes after Roux-en-Y gastric bypass (RYGBP) and RYGBP with fundus resection.
- Conditions
- Type 2 Diabetes, Morbid Obesity, Bariatric Surgery
- Trial name
- NCT05854875
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Roux en Y gastric bypass with fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Type 2 Diabetes
Development of Minimally Invasive Methodology for Diabetyping to Personalise Treatment to Realise Remission and Reversal of Type 2 Diabetes
Rationale: Lifestyle changes in diet and exercise can reverse type 2 diabetes (T2D), also referred to as T2D remission. Although combined lifestyle interventions for T2D remission are promising, not all persons react similarly to…
- Trial name
- 2DIAREM (NCT06125119)
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- TNO
Type 2 Diabetes (T2DM)
A Study of BGM0504 in Early T2DM With Obesity
This trial is conducted in China. The aim is to compare BGM0504 Injection 15 mg with semaglutide 1.0 mg in Chinese T2DM patients with obesity and inadequate control despite diet and exercise.
- Trial name
- NCT07743983
- Testing
- BGM0504, semaglutide
- Where
- China
- Volunteers
- 372 people
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.