Clinical trials: Type 2 Diabetes Risk
Overweight, Obesity
Effect of High Monounsaturated Fat Diet on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes
The purpose of this proposed randomized, controlled trial is to compare the effects of high monounsaturated fat diets and high carbohydrate diets on body weight, body composition, glycemic control, plasma lipids, and other…
- Conditions
- Overweight, Obesity, Type 2 Diabetes
- Trial name
- NCT00622960
- Testing
- High-MUFA diet, High-CHO diet
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Cincinnati
Cardiovascular Disease, Type 2 Diabetes
Complement and Cardiovascular Risk in Adolescents
This study evaluates how genetic variations in complement, a part of the immune system, affect cardiovascular risk in adolescents.
- Trial name
- CCRIA (NCT02821104)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Diabetes Mellitus, Type 2, Preterm Birth
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Preterm Birth, Pregnancy, High Risk, Diabetes, Gestational
- Trial name
- NCT04542148
- Testing
- Sliding Scale Insulin, Up-Titration of Home Insulin, Continuous Insulin Infusion
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes
Improving Risk Factors for Diabetes Complications in Primary Care
The purpose of this study is to test an intervention in primary care clinics to improve three risk factors for diabetes complications: glucose control, blood pressure and cholesterol.
- Trial name
- NCT00482768
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 2,493 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Type 2
SomaSignal Tests on Medical Management and Change in Risk in Patients With Diabetes
Despite the development of novel treatments, cardiovascular disease (CVD) remains the leading cause of death and disability. It has been observed in clinical practice, that the use of novel glycemia-lowering therapies with…
- Trial name
- NCT05256706
- Testing
- SomaSignal Informed Medical Management SSCVD, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 143 people
- Sponsor
- Emory University
Type 2 Diabetes Mellitus
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent…
- Trial name
- R2D2 (NCT01536808)
- Testing
- Cardiac RMI, Analysis telomere, Stress test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus Type 2, Childhood-Onset
DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese…
- Trial name
- DISCOVERY (NCT06525259)
- Where
- 20 sites in United States
- Volunteers
- 3,600 people
- Sponsor
- George Washington University
Diabetes Mellitus, Type 2, Genetics
Phenotyping Genetic Risk for Type 2 Diabetes
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2…
- Trial name
- NCT04024631
- Testing
- 75g glucose beverage (Glucola, Trutol, or similar brand), DXA, whole body
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Overweight and Obesity, PreDiabetes
Effect of Time-restricted Eating on Behaviour and Metabolism in Overweight Individuals at High Risk of Type 2 Diabetes
The aim of the present study is to investigate effects of 12 weeks time-restricted eating on behaviour and metabolism in individuals with overweight or obesity at high risk of type 2 diabetes.
- Trial name
- RESET (NCT03854656)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Type 2 Diabetes, Dietary Intervention
Effects of Combining Cocoa and Soy in Type 2 Diabetes
Diabetes is an increasingly common condition affecting millions of people world wide. The cornerstone of treatment is lifestyle that includes looking at the way how people eat.
- Trial name
- NCT01754662
- Testing
- Soy protein, Isoflavones, Cocoa
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Diabetic Foot Ulcer, Type 2 Diabetes Mellitus With Complication
Implementation of a Preventive Diabetic Foot Care Program for Patients at Risk of Diabetic Foot
This study aims to evaluate the effect of a preventive diabetic foot care program on the knowledge, behavior, self-management, and glycemic control levels of type 2 diabetic patients at risk of diabetic foot.
- Trial name
- NCT06770829
- Testing
- DiaFOOTCare Program, Ministry of Health and Education
- Volunteers
- 78 people
- Sponsor
- Akdeniz University
PreDiabetes, Metabolic Syndrome, Protection Against
Developing and Testing a Technology-Based Translation of the DPP to Address Prediabetes in a Primary Care Setting
DPPFit is a Healthy Lifestyle Intervention designed to reformat the effective strategies of the Diabetes Prevention Program (NDPP) into a tool for use in a primary care setting.
- Trial name
- DPPFit (NCT04564586)
- Testing
- DPPFit
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Augusta University
Heart Failure, Diabetes Mellitus
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This is a prospective, multicentre, unblinded, randomised, controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients with diabetes.
- Conditions
- Heart Failure, Diabetes Mellitus, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- TARTAN-HF (NCT05705869)
- Testing
- NT-proBNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 706 people
- Sponsor
- NHS Greater Glasgow and Clyde
Type 2 Diabetes Mellitus, Primary Prevention
The Impact of a Diabetes Risk Prediction Model in Primary Care.
Little evidence exists on the impact of diabetes risk scores, e.g. on physicians and patient's behavior, perceived risk of persons, shared-decision making and particularly on patient´s health.
- Trial name
- NCT03234322
- Testing
- external validated risk prediction model
- Where
- Germany
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Diabetes Type 2, Type II Diabetes Mellitus
Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors
This project aims to adapt, implement, and evaluate PLA based intervention in Rural Kabul, Afghanistan for TIIDM prevention and control.
- Trial name
- EMPOWER-D-Afg (NCT07350694)
- Testing
- PLA
- Where
- Afghanistan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- HealthNet Transcultural Psychosocial Organization
Type 2 Diabetes Mellitus
The Effects of Reducing Prolonged Sitting Bouts in Individuals at High Risk of or With Type 2 Diabetes
Over 3 million in the United Kingdom are now diagnosed with type 2 diabetes, with current estimates suggesting this will rise to over 5 million by 2025.
- Trial name
- UP FOR 5 (NCT03482596)
- Testing
- Reducing/breaking prolonged sitting
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Diabetes Mellitus, Type 2, Vascular Diseases
Effect of Thiazolidinedione Treatment Vascular Risk Markers
The purpose of this study is to examine the effects of two diabetes medications, rosiglitazone and pioglitazone, on markers of vascular disease in subjects with type 2 diabetes.
- Trial name
- NCT00571506
- Testing
- Rosiglitazone, Pioglitazone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arkansas
Cardiovascular Risk Factor
Virtual Lifestyle Intervention for Weight Management and Cardiovascular Heal
This is a 90-day, single-arm, open-label, fully virtual community lifestyle intervention study evaluating the effects of a multicomponent lifestyle intervention on weight management and cardiovascular health.
- Trial name
- NCT07572721
- Testing
- Multicomponent Virtual Lifestyle Intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Truemedicine Inc
Cardiovascular Disease Risk, Type 2 Diabetes Risk
The Effect of Pecans on Biomarkers of Risk for Cardiovascular Disease and Diabetes
The objective of this randomized, controlled feeding study is to investigate the potential health benefits of a pecan-containing diet.
- Trial name
- NCT01950806
- Testing
- Pecan-containing diet, Nut-free diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Tufts University
Diabetes Mellitus, Type 2
Effects of Legume Intake on Cardiovascular Risk Factors Among Adults at Risk for Diabetes
This randomized cross-over study was designed to investigate the effects of legume enriched diet consumption on cardiovascular risk factors among first degree relatives of diabetic patients.
- Trial name
- NCT01906099
- Testing
- nutritional intervention, life style modification
- Where
- Iran
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences