Clinical trials: Type 2 Diabetes Risk
Diabetes Mellitus Type 2
Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects with Type 2 Diabetes
Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by an abnormal accumulation of fat not due to alcohol or drug consumption that can evolve into steatohepatitis (NASH), fibrosis and cirrhosis.
- Trial name
- PoLiFat (NCT06895018)
- Testing
- Supplementation with Polyphenol Rich Drink
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Diabetes Mellitus, Type 1
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
The purpose of this study is to assess the safety and pharmacokinetics (PK) of teplizumab in participants with Stage 2 type 1 diabetes who are <8 years of age.
- Trial name
- PETITE-T1D (NCT05757713)
- Testing
- teplizumab
- Where
- 10 sites in United States
- Volunteers
- 23 people
- Sponsor
- Sanofi
Osteoarthritis, Knee, Myocardial Infarction, Acute
Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR)
This study aims to develop, implement, and determines the effectiveness of a personalized medicine approach to each individual's phenotype, based on an innovative physical exercise program to promote the treatment of pain and…
- Conditions
- Osteoarthritis, Knee, Myocardial Infarction, Acute, Hypertension, Dyslipidemias
- Trial name
- A3-COR (NCT05999110)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Obesity, Diabetes Mellitus
Type 2 Diabetes Primary Prevention for At Risk Girls
Purpose: To evaluate two approaches to prevent obesity and type 2 diabetes in young girls. The Need: We are experiencing an epidemic of childhood obesity.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- NCT00063674
- Testing
- Nutrition Education, After-school dance class
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Diseases, Mortality
Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment.
- Conditions
- Cardiovascular Diseases, Mortality, Type 2 Diabetes Mellitus, Cognitive Decline
- Trial name
- NCT03192410
- Testing
- Dietary intake, Lifestyle factors, Blood biomarkers
- Where
- Netherlands
- Volunteers
- 4,837 people
- Sponsor
- Wageningen University
Type 2 Diabetes Mellitus (T2DM)
2025 Hypoglycemia Early-Warning and Physician-Nurse Collaborative Management Trial in Type 2 Diabetes
The goal of this clinical study is to learn whether a physician-nurse collaborative intervention guided by an Intelligent Hypoglycemia Risk Early-Warning System can reduce hypoglycemia and improve glycemic control in hospitalized…
- Trial name
- NCT07314749
- Testing
- Physician-Nurse Collaborative Intervention Guided by Intelligent Hypoglycemia Risk Early-Warning System, Usual Care
- Where
- China
- Volunteers
- 1,255 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Diabetes Mellitus, Type 2, Obesity
Effect of Dairy Consumption on Glycemic Control, Body Weight and Cardiovascular Risk Factors
The aim of this study is to determine the relationship between the percentage of calories from dairy intake and long-term glycemic control and weight maintenance in patients with type 2 diabetes who participate in an intensive…
- Trial name
- NCT02896140
- Testing
- Type 2 diabetes in WhyWAIT Program
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Joslin Diabetes Center
Diabetes, Diabetes Mellitus, Type 1
Changing Diabetes® World Tour
This study is conducted in the Middle East, Northern Africa and Europe. The aim of this study is to contribute to the design of a simple screening strategy for countries in scope, by exploring the association between risk factors…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01437072
- Testing
- No treatment given
- Where
- 3 sites in Portugal, Saudi Arabia and 1 more
- Volunteers
- 8,304 people
- Sponsor
- Novo Nordisk A/S
Type II Diabetes Mellitus, Obesity
A Study Evaluating the Effects of a High Viscosity Non-starch Polysaccharide (PolyGlycopleX® - PGX®) on Glycemic Control, Cardiometabolic Risk Factors and Weight Loss in Overweight and Obese Type II Diabetics
One out of two adults in Canada is currently overweight and therefore at increased risk for a number of medical conditions including diabetes, high blood pressure, heart attacks and stroke.
- Trial name
- NCT01644201
- Testing
- PolyGlycopleX® - PGX®
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- InovoBiologic Inc.
Pre-diabetes, Pre-diabetic State
VA|PREVENTION: Randomized Controlled Trial of a Person-Centred Digital Intervention to Prevent Diabetes in High-Risk Adults
The goal of this clinical trial is to help prevent the development of type 2 diabetes (T2D) in adults who are at risk. The study will test a digital intervention called VA|PREVENTION, a web application designed to support and…
- Trial name
- VA|PREVENTION (NCT07021144)
- Testing
- VA|PREVENTION web application (digital intervention), Type 2 Diabetes Guidebook
- Where
- 16 sites in Portugal
- Volunteers
- 180 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Diabetes Mellitus, Type 2
Incretin-based Drugs and Pancreatic Cancer
The purpose of this study is to determine whether incretin-based drugs (used to treat type 2 diabetes) taken either alone in or combination with other anti-diabetic drugs are associated with an increased risk of pancreatic cancer…
- Trial name
- NCT02475499
- Testing
- DPP-4 inhibitors, GLP-1 analogs, Sulfonylureas
- Where
- Canada
- Volunteers
- 886,172 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Diabetes Mellitus, Type 2
Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes
Aim: The United Kingdom Prospective Diabetes Study (UKPDS) showed a reduction in cardiovascular events in obese patients with type-2-diabetes treated with metformin compared with other hypoglycaemic treatments with no difference…
- Trial name
- NCT00118963
- Testing
- Metformin, Insulin BIAsp30 (Novolog 70/30), Repaglinide
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 2
Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)
The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to…
- Trial name
- NCT01897532
- Testing
- Linagliptin
- Where
- 649 sites in United States, Argentina and 25 more
- Volunteers
- 6,991 people
- Sponsor
- Boehringer Ingelheim
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Insulin Treated Type 2 Diabetes With High Risk of Hypoglycemia
Efficacy of Flash Glucose-Sensing Technology on the Occurrence of Cardiac Arrhythmias Associated With Hypoglycemia
Hypoglycemia, frequently asymptomatic, may lead to cardiac arrythmias and induce an increased risk of cardiovascular morbidity and mortality in patients with type 2 diabetes (T2D).
- Trial name
- NCT03570138
- Testing
- FREESTYLE LIBRE device, a Flash Continuous Glucose Monitoring System, Usual self monitoring Blood Glucose device
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Type 2 Diabetes Mellitus
Gliflozins and Cardiovascular Risk Factors in Type 2 Diabetes (GIOIA)
GIOIA represents a multicenter pragmatic prospective cohort study, aimed at evaluating the effects of SGLT2 inhibitors currently marketed (dapagliflozin, canagliflozin, empagliflozin) on markers of vascular, myocardial and renal…
- Trial name
- GIOIA (NCT03918148)
- Testing
- SGLT-2i, DPP-4i
- Where
- Italy
- Volunteers
- 1,150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type2 Diabetes Mellitus
Adipose Tissue Expandability and Type 2 Diabetes
The goal of the study is to analyze deviations in adipogenic potential and metabolic properties of preadipocytes in subjects with genetic predisposition to type 2 diabetes, and thus identify factors that underlie hypertrophic…
- Trial name
- LIMEX (NCT03155412)
- Where
- Czechia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Type 2 Diabetes Risk Reduction in Young Adults
Holistic Lifestyle mHealth Intervention for Risk Reduction of Type 2 Diabetes Mellitus in Young Adults
The goal of this clinical trial (randomized controlled trial) is to examine the effectiveness of a holistic lifestyle mHealth intervention in reducing the risk of type 2 diabetes mellitus.
- Trial name
- NCT07604012
- Testing
- Holistic mHealth Intervention
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fatima Jinnah Women University
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Type 2 Diabetes, Fraity Syndrome
Results Of Vivifrail Exercise In Older Type 2 Diabetic Patients With Fraity Syndrome
A randomized controlled clinical trial that will test how physical exercise will impact outcomes of functional ability, cognitive function and quality of life in older patients with type 2 diabetes who have been diagnosed as…
- Conditions
- Type 2 Diabetes, Fraity Syndrome, Exercise Intervention
- Trial name
- NCT07506278
- Testing
- Vivifrail Exercise Programme Training
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- National Geriatric Hospital