Clinical trials: Type 2 Diabetes Risk
Metabolic Syndrome, Abdominal Obesity
Copenhagen Obesity Risk Assessment Study
The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately…
- Conditions
- Metabolic Syndrome, Abdominal Obesity, Heart Disease, Type 2 Diabetes
- Trial name
- COBRA (NCT00655902)
- Testing
- Trans fat (soy bean oil), Control fat (sunflower oil)
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetes Mellitus, Percutaneous Coronary Intervention
Correlation Between Targeted HbA1c Values and Prevention of Recurrent Cardiovascular Events in Type 2 Diabetes After PCI
Diabetes is a leading social and economic burden in the world. It is the main reason of macrovascular disease incidence and mortality.
- Trial name
- CATHEDRAL (NCT05134129)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Shanghai 10th People's Hospital
Type 2 Diabetes
Lifestyle Intervention in Individuals With Low or High Genetic Risk for Type 2 Diabetes
The aim of the study is to compare the effect of lifestyle intervention (diet and physical activity) by applying modern approaches to lifestyle changes on the prevention of incident T2DM and the worsening of hyperglycemia in…
- Trial name
- T2D-GENE (NCT02709057)
- Testing
- Lifestyle intervention
- Where
- Finland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Diabetes Mellitus, Type 2, Obesity
The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2
Based on the findings of our formative work, conduct a one-year intervention among African American Adults using revised culturally tailored materials to examine differences in Healthy Eating Index (HEI) and type 2 diabetes…
- Trial name
- DG3D-Phase2 (NCT05254496)
- Testing
- Dietary Intervention Classes
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Type 2 Diabetes, Glycemic Control
Latinos Understanding the Need for Adherence in Diabetes
The Latinos Understanding the Need for Adherence in Diabetes (LUNA-D) study, is a randomized controlled trial testing the effectiveness of an integrated behavioral health and primary care chronic care disease management…
- Conditions
- Type 2 Diabetes, Glycemic Control, Cardiovascular Risk Factors, Psychological Distress
- Trial name
- LUNA-D (NCT03983499)
- Testing
- Special Intervention
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- San Diego State University
Diabetes Mellitus, Type 2, Gestational Diabetes
Hormonal and Inflammatory Changes During Pregnancy in Women With Glucose Metabolic Disorders.
The first aim of this study is to describe maternal hormonal and inflammatory changes during pregnancy in women that differ metabolically (limited to women with type 2 diabetes, gestational diabetes and/or overweight).
- Conditions
- Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic
- Trial name
- HI-MET (NCT04617405)
- Testing
- No interventions
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Type 2 Diabetes, Impaired Glucose Tolerance
Efficiency and Cost-effectiveness of a Culturally Adopted Lifestyle Intervention Program - the MEDIM Study.
An increasing proportion of Sweden's population comprises non-European immigrants, who constitute a high risk-population for T2D.
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Obesity, Physical Activity
- Trial name
- MEDIM (NCT01420198)
- Testing
- Lifestyle intervention
- Where
- Sweden
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Region Skane
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 2
Glucagon-like Peptide (GLP) Utilization and Safety
This study will assess the utilization patterns (adherence, source of the index antidiabetic agent (ADA) and treatment modification) of the marketed glucagon-like peptide-1 (GLP-1) receptor agonists (exenatide and liraglutide)…
- Trial name
- NCT01767389
- Testing
- The GLP-1 receptor agonist users, DPP-4 inhibitor users, Other ADA users
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes
Improving Risk Factors for Diabetes Complications in Primary Care
The purpose of this study is to test an intervention in primary care clinics to improve three risk factors for diabetes complications: glucose control, blood pressure and cholesterol.
- Trial name
- NCT00482768
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 2,493 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pancreatic Cancer
A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs
EXCEED is a non-interventional post-authorisation safety study aiming to assess the risk of developing pancreatic cancer among type 2 diabetes mellitus (T2DM) patients who initiated exenatide compared to those who initiated other…
- Trial name
- EXCEED (NCT05663515)
- Testing
- Exenatide, Non-GLP-1 RA based glucose lowering drugs
- Where
- 8 sites in Denmark, Finland and 5 more
- Volunteers
- 24,000 people
- Sponsor
- AstraZeneca
Type 2 Diabetes
A Comprehensive Longitudinal Cohort Study in Type 2 Diabetes With High Risk of Cardiovascular Diseases in China
In 2010, the sponsor conducted an observational study, entitled as "Nationwide Assessment of Cardiovascular Risk Factors: Blood Pressure, Blood Lipid, and Blood Glucose, in Chinese Patients with Type 2 Diabetes - 3B Study " which…
- Trial name
- CCMR-3B Ext (NCT01307410)
- Volunteers
- 5,000 people
- Sponsor
- China Cardiometabolic Registries
Diabetes Mellitus, Type 2, Catheterization, Peripheral
Incidence of Complications of Peripheral Venous Access in the Type 2 Diabetic Population
Diabetes Mellitus type 2 (T2DM) is one of the most frequent metabolic diseases worldwide. It is expected that in 2035 around 600 million people will suffer from the disease.
- Conditions
- Diabetes Mellitus, Type 2, Catheterization, Peripheral, Upper Extremity Deep Vein Thrombosis, Catheter-Related Infections
- Trial name
- NCT04499638
- Testing
- Peripheral vascular catheters
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Type 2 Diabetes Mellitus
Type 2 Diabetes: Risk Perceptions and Self-management Behaviour
This pilot randomised controlled trial (RCT) aims to assess the feasibility of using a new type of risk communication intervention for people with Type 2 diabetes mellitus (T2DM) in primary care and to evaluate its potential…
- Trial name
- NCT03840850
- Testing
- Personalized Risk Communication for People with Type 2 Diabetes
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Obesity, Type 2 Diabetes
Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome
The purpose of this study is to determine the ability of acute exercise to regulate fat metabolism in muscle of overweight and obese people compared to lean people.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Diseases, Acute Exercise
- Trial name
- NCT05034380
- Testing
- Acute exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Coronary Artery Disease, Atrial Fibrillation
The Genomic Medicine at VA Study
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer
- Trial name
- GenoVA (NCT04331535)
- Testing
- Polygenic risk score (PRS)
- Where
- United States
- Volunteers
- 1,071 people
- Sponsor
- Boston VA Research Institute, Inc.
Diabetes Mellitus, Type 2
To Assess the Risk of Acute Pancreatitis in Patients With Type 2 Diabetes Mellitus Treated With Empagliflozin
To compare the risk of acute pancreatitis in patients with Type 2 diabetes mellitus (T2DM) newly initiating empagliflozin to that of patients newly initiating other oral non-incretin/non-Sodium glucose co-transporter-2 inhibitor…
- Trial name
- NCT05162014
- Testing
- empagliflozin, Oral non-incretin/non-sodium glucose co-transporter-2 inhibitors (SGLT2)-containing hypoglycaemic agents
- Where
- Germany
- Volunteers
- 494,679 people
- Sponsor
- Boehringer Ingelheim
Atherosclerosis, Type 2 Diabetes
Vitamin C and Cardiovascular Risk
Study Goal #1: Determine the optimal oral dose of vitamin C to reduce surrogate markers of atherosclerosis (blockages in blood vessels) following the consumption of an atherogenic high fat lunch in type 2 diabetic individuals.
- Trial name
- NCT00534014
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico