Clinical trials: Type 2 Diabetic
Diabetes Mellitus, Type 2
Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics
Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced.
- Trial name
- InsuReB (NCT03196154)
- Testing
- Fasting insulin level, Plasma drug level
- Where
- Malaysia
- Volunteers
- 255 people
- Sponsor
- Clinical Research Centre, Malaysia
Covid19, Diabete Type 2
COVID-19 Infection in Diabetic Patients
It was observed during the last period of COVID-19 pandemic that diabetic patients had a worse prognosis and more deteriorated clinical features than other patients
- Conditions
- Covid19, Diabete Type 2, Non Diabetic Patients, Chest CT Scan
- Trial name
- NCT04765254
- Testing
- no intervention as it is an observational study
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2 With Acute Coronary Syndrom
Predictors of Coronary Revascularization Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome
To explore the metabolic outcomes of PCI versus CABG in diabetic patients presented by ACS. To verify the diagnostic and prognostic value of speckle tracking echocardiography in early detection of MACE after ACS in diabetic…
- Trial name
- NCT04354740
- Testing
- with percutaneous coronary intervention (PCI) are with new-generation drug-eluting stents (DES)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Dental Implant, Diabetes Mellitus, Type 2
Bioactive Microstructured Anti Microbial Precoated Surface Implant Versus Non-coated Surface Implant in Type 2 Diabetic Patients in the Mandible
Dental implant's surface properties significantly influence both biological and mechanical integration. Surface bio-treatment could accelerate and enhance bone regeneration, ensuring successful implantation.
- Trial name
- NCT06528327
- Testing
- Pre coated impants, Non coated implant surface
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Hams Hamed Abdelrahman
Diabetes Mellitus, Type 2, Peripheral Arterial Disease
REducing Diabetic MacrovascUlar Complications DuE to Peripheral Arterial Disease- REDUCE-PAD
This is a Phase IIa, multi-centre study conducted at 3 sites in Singapore (SGH and NUHS, KTPH). 70 patients with diabetes mellitus (DM) and peripheral arterial disease (PAD) will be randomised in a ratio 1:1 to receive normal…
- Trial name
- REDUCE-PAD (NCT05912218)
- Testing
- MEI6570
- Where
- Singapore
- Volunteers
- 70 people
- Sponsor
- National Heart Centre Singapore
Congestive Heart Failure, Type 2 Diabetes Mellitus
Liraglutide and Heart Failure in Type 2 Diabetes
Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with insulinotropic properties. Apart from the glycemic actions, cardiovascular effects by GLP-1 have recently been reviewed.
- Trial name
- NCT01425580
- Testing
- liraglutide, glimepiride, Metformin
- Where
- 2 sites in Sweden
- Volunteers
- 62 people
- Sponsor
- Thomas Nystrom
Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8 mmol/L after approximately 12 hours fasting.
- Trial name
- NCT03902288
- Testing
- Fresh pomegranate juice
- Where
- Jordan
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus
Background: Heart failure is a major cause of morbidity and mortality in diabetes mellitus, but its pathophysiology is poorly understood.
- Trial name
- PREDICT (NCT03132129)
- Testing
- Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring
- Where
- United Kingdom
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Diabetic Retinopathy
Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens
Diabetic retinopathy (DR) is an important cause of blindness.
- Trial name
- CORRECT (NCT02587741)
- Testing
- Metformin, Lantus, Novomix30
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
GAD Ab Positive Clinically Type 2 Diabetic Patients
Intervention to Preserve Beta-Cell Function in GAD Ab-Positive Diabetes
We tested the hypothesis that insulin therapy rather than sulfonylurea (SU) treatment has a preferable outcome to reverse or preserve beta cell function in the patients with diabetes that is called slowly progressive…
- Trial name
- NCT00232375
- Testing
- Insulin
- Where
- Japan
- Volunteers
- 42 people
- Sponsor
- Tokyo Study Group
Diabetes, Clopidogrel Resistance
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes.
- Conditions
- Diabetes, Clopidogrel Resistance, Amyloid, Insulin Resistance
- Trial name
- NCT04027712
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Type 2 Diabetes
Progression and Etiology of Cortical Porosity in Diabetic Bone Disease
Type 2 diabetes is associated with increased cortical bone porosity and increased fracture risk. The goal of this proposed study is to understand the longitudinal evolution of cortical bone porosity and to investigate the…
- Trial name
- PREPT2D (NCT04208230)
- Testing
- XtremeCT
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Type 2 Diabetes, Dyslipidemia
Fenofibrate and Metformin Insulin Sensitivity in Type 2 Diabetics Study
Double-blind, randomized placebo-controlled study in type 2 diabetes and dyslipidemic patients.Patients will be randomized to one of four treatment arms for 16 weeks: placebo, fenofibrate, metformin, or metformin and fenofibrate…
- Trial name
- NCT00362765
- Testing
- Fenofibrate, Metformin
- Where
- 3 sites in Finland, Ireland and 1 more
- Volunteers
- 8 people
- Sponsor
- Solvay Pharmaceuticals
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes
This randomized controlled clinical trial aims to evaluate the effectiveness of a para-probiotic-based oral care protocol in improving periodontal health and glycemic control in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- PPDM2 (NCT07069166)
- Testing
- Para-probiotic oral care, Chlorhexidine oral care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Efficacy of Trimetazidine in Diabetic Patients
Subclinical diastolic dysfunction represents the early phase of diabetic cardiomyopathy and is a common complication among type 2 diabetic patients that increases mortality rate among those patients and can progress to heart…
- Trial name
- NCT05556005
- Testing
- Trimetazidine Dihydrochloride
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2
Effectiveness of a High-risk Diabetic Patients Program
The purpose of this study is to determine whether case management for type 2 diabetic patients with target-organ damage improves quality of care compared to usual care.
- Trial name
- NCT01051245
- Testing
- Case manager counseling, Usual care
- Where
- Argentina
- Volunteers
- 223 people
- Sponsor
- Hospital Italiano de Buenos Aires
Obesity, Diabetes Mellitus, Type 2
A Study of the Safety and Efficacy of Topiramate in the Treatment of Obese, Type 2 Diabetes Patients on a Controlled Diet
The purpose of this study is to determine the efficacy and safety of topiramate compared with placebo in obese, Type 2 diabetic patients on a controlled diet.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00231530
- Testing
- topiramate
- Volunteers
- 541 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Type 2 Diabetes Mellitus
Insulin Glargine Versus Twice-Daily NPH
To compare the efficacy and safety of once-nightly insulin glargine versus twice-daily NPH insulin in ethnic minority type 2 diabetic patients inadequately treated with once-nightly NPH insulin alone.
- Trial name
- NCT00687453
- Testing
- Insulin glargine at bedtime instead of NPH, NPH twice-daily
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Charles Drew University of Medicine and Science
Diabetes Mellitus
Safety and Efficacy of BGP-15 in Patients With Type 2 Diabetes Mellitus
This is a safety and dose finding efficacy study to evaluate the effects of BGP-15 over the dose range of 100 mg/day to 400 mg/day.
- Trial name
- NCT01069965
- Testing
- BGP-15 100 mg QD, BGP-15 100 mg BID, BGP-15 200 mg QD
- Where
- 30 sites in United States, Germany and 1 more
- Volunteers
- 196 people
- Sponsor
- N-Gene Research Laboratories, Inc.
Type 2 Diabetes, Overweight
The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
The aim of this study is to evaluate the effect of glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes.
- Conditions
- Type 2 Diabetes, Overweight, Disordered Eating Behaviors
- Trial name
- NCT06243536
- Testing
- Semaglutide, standard of care
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Sestre Milosrdnice