Clinical trials: Type I Diabetes Mellitus
Erectile Dysfunction
Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes
Asses efficacy of Vardenafil in patients with type 1 diabetes and erectile dysfunction
- Trial name
- NCT00660998
- Testing
- Levitra (Vardenafil, BAY38-9456)
- Volunteers
- 318 people
- Sponsor
- Bayer
Type 1 Diabetes
A Learning Algorithm for MDI Individuals With Type 1 Diabetes to Adjust Recommendations for High Fat Meals and Exercise Management
McGill artificial pancreas lab has developed a learning algorithm using a reinforcement learning approach to adjust basal and bolus recommendations for high-fat meals and exercise management for individuals with type 1 diabetes…
- Trial name
- NCT05041621
- Testing
- Sensor augmented MDI therapy plus mobile application
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 1
Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes
The closed-loop delivery system is composed of an insulin pump, a continuous glucose sensor and a dosing algorithm that calculates the insulin dose to infuse based on sensor readings.
- Trial name
- NCT02814123
- Testing
- 24-hour inpatient intervention
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 2
isCGM With Education and Feedback for Non-Insulin Dependent Type 2 Diabetes
Glycemic control is an important for adults with diabetes. Self-monitoring of glucose can help adults with type 2 diabetes (T2DM) meet their glucose targets.
- Trial name
- iCUDE (NCT05319496)
- Testing
- Intermittently scanned continuous glucose monitor (isCGM), Education and coaching
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes, Type 2 Diabetes
Blood Glucose Response to Meals of Varying Glycemic Index in Youth With Type 1 & 2 Diabetes
Research to date suggests that the selection of lower glycemic index foods, that is, foods provoking a slower, more sustained blood sugar response, may result in improved glycemic control in youth with diabetes.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Impaired Glucose Metabolism
- Trial name
- NCT00545727
- Testing
- Diet, Standard diet
- Volunteers
- 36 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 1 Diabetes Mellitus
Comparison of Insulins Aspart and Lispro in Insulin Pumps
The purpose of the study is to compare the glycemic control between insulins aspart and lispro 48 to 100 hours after pump infusion line change in subjects with type 1 using diabetes using an insulin pump.
- Trial name
- NCT00461331
- Testing
- Insulin Aspart, Insulin Lispro
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tulane University Health Sciences Center
Cardiovascular Diseases
Endothelial Function in a Sample Group of Patients From the ICARE Study
The ICARE study, clinicaltrials.gov ID number: NCT00220831 and protocol number KL-2004, is recruiting diabetic patients with haptoglobin phenotype 2-2, which are randomised to either Vitamin E 400IU per day or placebo.
- Trial name
- NCT00314379
- Testing
- Vitamin E 400IU/day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Technion, Israel Institute of Technology
Type 1 Diabetes Mellitus
Omnipod 5 Implementation in Belgian Paediatric Diabetes Care
This study will evaluate the introduction and use of the Omnipod® 5 hybrid closed-loop insulin delivery system in children and adolescents with type 1 diabetes following its reimbursement in Belgium.
- Trial name
- O5-IMPACT (NCT07785037)
- Testing
- Tubeless Hybrid Closed-Loop Insulin Delivery System
- Volunteers
- 200 people
- Sponsor
- Queen Fabiola Children's University Hospital
Type 1 Diabetes Mellitus
Evaluation of a Simulation-Based Educational Tool for Personalized Feedback in Insulin Therapy Management
This study combines data collection and simulation-based education, and it will enroll up to 36 adults with T1DM who already have experience with insulin pump therapy and some experience with a continuous glucose monitor (CGM).
- Trial name
- NCT01767831
- Testing
- iBOLUSED
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Duration of The Honeymoon Phase of Type 1 Diabetes: A Comparison of Insulins Detemir, Glargine and NPH
To determine whether using a long-acting insulin analog at the time of diagnosis, instead of intermediate-acting insulin, affects the rate of loss of the body's ability to make insulin in children with newly diagnosed type 1…
- Trial name
- NCT00564018
- Testing
- Insulin detemir, Glargine, NPH
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
Reactive Oxygen Species in the Pathogenesis of Diabetic Complications
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy and incipient nephropathy in these models.
- Trial name
- NCT00703989
- Testing
- benfotiamine, α-lipoic acid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Type 1
A Study to Look at How Safe Insulin NNC0471-0119 is and How it Works in People With Type 1 Diabetes Mellitus
This study is looking at the safety of the new medicine, insulin NNC0471-0119, its concentrations in the blood and effect on blood sugar for the treatment of type 1 diabetes.
- Trial name
- NCT04655690
- Testing
- NNC0471-0119, Fast-acting insulin aspart
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Apidra Children & Adolescents Study
Primary Objective: Evaluate the percentage of patients achieving glycosylated hemoglobin (HbA1c) level < 8% (in patients of 6-12 years old) and HbA1c level < 7.5% (in patients of 13-17 year old) at 6 and 12 months of treatment…
- Trial name
- NCT01202474
- Testing
- INSULIN GLULISINE, INSULIN GLARGINE
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus
Pharmacokinetics of Ultra-Rapid-Acting Insulin Lispro (URAL) in Type 1 Diabetes Mellitus
To compare the early pharmacokinetic exposure of URAL and insulin lispro (ILisp).
- Trial name
- NCT02206568
- Testing
- URAL
- Where
- Germany
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Diabetes, Diabetes Mellitus, Type 1
Comparison of Biphasic Human Insulin 30 With Biphasic Insulin Aspart in Subjects With Diabetes
This trial is conducted in Europe. The aim of this trial is to compare the glycaemic control of biphasic insulin aspart (BIAsp) 70 and/or BIAsp 50 with biphasic human insulin (BHI) 30 treatment.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01520818
- Testing
- biphasic insulin aspart 50, biphasic insulin aspart 70, biphasic human insulin 30
- Where
- 77 sites in Belgium, France and 3 more
- Volunteers
- 666 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Incretin Effect and Use After Clinical Islet Transplantation
We aim to study if the administration of medications to increase the secretion of hormones from the intestines can improve glycemic control, reduce insulin use and promote β-cell regeneration/expansion in subjects with type 1…
- Trial name
- NCT00768651
- Testing
- Pantoprazole, Sitagliptin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Diabetes Mellitus
DSME or DSME + MI in T1DM on Glycemic Control
This study evaluates the effect of diabetic knowledge and self care behavior (DSME) alone or DSME plus motivational interviewing on glycemic control among children and adolescents with DM type 1.
- Trial name
- NCT03104829
- Testing
- Motivational interviewing, DSME participants in this arm will receive standard care for diabetes (DSME) at the beginning of the study and 3 months later
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Diabetic Kidney Alarm (DKA) Study
The overarching goals of this study are to determine whether tubular dysfunction (elevated urine sodium, bicarbonate and amino acids) and injury (elevated kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated…
- Trial name
- DKA (NCT03128229)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Low-dose rhIL-2 in Patients With Recently-diagnosed Type 1 Diabetes
Type 1diabetes (T1D) is caused by autoimmune destruction of the pancreatic islet ß-cells, leading to an absolute deficiency in insulin.
- Trial name
- DIABIL-2 (NCT02411253)
- Testing
- rhIL-2
- Where
- 34 sites in Belgium, France and 4 more
- Volunteers
- 141 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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