Clinical trials: Type I Diabetes Mellitus
Type 1 Diabetes
A Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults With Type 1 Diabetes
The primary objective of the study is to determine whether the routine use of Continuous Glucose Monitoring (CGM) without Blood Glucose Monitoring (BGM) confirmation is as safe and effective as CGM used as an adjunct to BGM.
- Trial name
- REPLACE-BG (NCT02258373)
- Testing
- CGM+BGM, CGM Only
- Where
- 14 sites in United States
- Volunteers
- 226 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Tegoprubart (AT-1501) is a monoclonal antibody. Antibodies are Y-shaped proteins that are produced naturally by the subject's immune system to attack and fight foreign substances that cause illness.
- Trial name
- Tegoprubart (NCT06305286)
- Testing
- Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Type 1 Diabetes (T1D), Menopause
Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes
Improvements in diabetes care and technology have led to people with type 1 diabetes living longer. There are now more seniors than ever living with this complex health condition.
- Trial name
- FLEX-T1D (NCT07851662)
- Testing
- Resistance exercise
- Where
- 3 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
A Pilot Study to Evaluate the Safety of Terbutaline in Children With Type 1 Diabetes
The purpose of the study is to gain experience with the use of terbutaline in children with T1D and to determine that there is not a frequent serious, unexpected, uncontrollable effect on short-term glycemic control.
- Trial name
- NCT00607503
- Testing
- Terbutaline
- Where
- 6 sites in United States
- Volunteers
- 9 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus
BD FlowSmart™ Subcutaneous Insulin Infusion Set User Preference and Claims Study
Continuous Subcutaneous Insulin Infusion (CSII) via insulin pump therapy has been shown to improve quality of life and glucose control in many patients with diabetes opting for this treatment modality.
- Trial name
- NCT02662842
- Testing
- FlowSmart Infusion Set, Current Infusion Set
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Becton, Dickinson and Company
Type 1 Diabetes Mellitus, Diabetes Self-Management Education
DiaBuddy: AI-Enabled Digital Self-Management for Youth With Type 1 Diabetes
The goal of this clinical trial is to learn whether DiaBuddy, a digital self-management app, can help children and adolescents with Type 1 diabetes better manage their condition and reduce the burden experienced by their…
- Conditions
- Type 1 Diabetes Mellitus, Diabetes Self-Management Education, Caregiver Burden
- Trial name
- DiaBuddy (NCT07861373)
- Testing
- DiaBuddy: AI-Enabled Digital Self-Management Intervention, Usual Diabetes Care
- Volunteers
- 140 people
- Sponsor
- Dr. Juwayria Omar
Diabetes, Diabetes Mellitus, Type 1
A Non-interventional, Post Marketing Surveillance (PMS) Study of Tresiba® (Insulin Degludec) to Evaluate Long Term Safety and Efficacy in Patients With Diabetes Mellitus in Routine Clinical Practice in India
This study is conducted in Asia. The aim of the study is to evaluate long term safety and efficacy of Tresiba® (insulin degludec) in patients with diabetes mellitus in routine clinical practice in India.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02117622
- Testing
- insulin degludec
- Where
- 38 sites in India
- Volunteers
- 1,056 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise Physiology Study
People with type 1 diabetes often find exercise very difficult to manage, because of the high risk for low blood glucose levels.
- Trial name
- NCT03090451
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus, Hypoglycemia
Hypoglycaemia Awareness Restoration Programme
Insulin treatment for type 1 diabetes inevitably carries risk of hypoglycaemia (low blood sugar) which can be severe enough to cause coma, seizure, even death.
- Trial name
- HARPdoc (NCT02940873)
- Testing
- HARPdoc courses, BGAT courses
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 99 people
- Sponsor
- King's College London
Diabetes Mellitus, Diabetes Mellitus, Type 1
A Novel mHealth Application Guided by an Optimization Algorithm for T1D Sensor-Augmented Insulin Injection Users
The Artificial Pancreas lab at McGill University has developed an optimization algorithm for adults with Type 1 Diabetes (T1D) on Multiple Daily Injection (MDI) therapy with the adjunctive use of glucose sensor technology…
- Trial name
- NCT04123054
- Testing
- Mobile App, Mobile App + Basal-Bolus Optimization Algorithm
- Where
- 2 sites in Canada
- Volunteers
- 84 people
- Sponsor
- McGill University
Type 1 Diabetes
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and…
- Trial name
- SOTA (NCT05696366)
- Testing
- Sotagliflozin, Volagidemab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Diego
Type1 Diabetes Mellitus, Adiposity
Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes
The purpose of this study is to assess the effects of adiposity on resistance to insulin's ability to suppress hepatic glucose production and to stimulate peripheral glucose metabolism in adolescents with type 1 diabetes.
- Trial name
- T1D (NCT03582956)
- Testing
- Euglycemic hyperinsulinemic clamp with tracer enhancement
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
New-onset Type 1 Diabetes Mellitus
Inducing Remission in Type 1 Diabetes With Alefacept
The purpose of this trial is to test whether a drug called alefacept will slow or halt destruction of the beta cells in the pancreas.
- Trial name
- T1DAL (NCT00965458)
- Testing
- Alefacept
- Where
- 15 sites in United States
- Volunteers
- 49 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Effect of Paired Testing to Poorly Controlled Chinese Diabetes on Glycemic Control and Self Care
This study aims is to evaluate the effect of introducing paired testing on actual testing frequency, glycemic control, psychosocial and behavioural aspects of poorly controlled diabetes patients in China.
- Trial name
- NCT02225691
- Testing
- Paired testing of blood glucose Accu-Chek®
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 6th People's Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
PROMISE Study: An Evaluation of an Implantable Continuous Glucose Sensor up to 180 Days
The purpose of this clinical investigation is to evaluate the accuracy of the Eversense® continuous Glucose Monitoring System (Eversense® 180 CGM System) measurements when compared with reference standard measurements up to 180…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PROMISE (NCT03808376)
- Testing
- Continuous Glucose Monitoring System
- Where
- 8 sites in United States
- Volunteers
- 208 people
- Sponsor
- Senseonics, Inc.
Type 1 Diabetes Mellitus
Combined Basal-bolus Insulin and Post-exercise Carbohydrate Feeding Strategy in T1DM
The investigators hypothesise that reducing basal insulin dose (Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk), whilst employing current carbohydrate feeding and rapid-acting insulin dose recommendations…
- Trial name
- NCT02204839
- Testing
- Basal insulin dose
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Northumbria University
Type 1 Diabetes
Ketoacidosis in Individuals With Type I Diabetes Mellitus (T1DM)
The purpose of this study is to investigate individuals with type 1 diabetes who were disconnected from their insulin pump and insulin therapy was started again after positive ketones (U) in the urine or blood β-hydroxybutyrate.
- Trial name
- NCT00970567
- Testing
- Different insulin therapy at different time points
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Charite University, Berlin, Germany
Hypoglycemia
Hypoglycemia Biomarkers to Predict Timing of a Hypoglycemic Event
The study aims to obtain a panel of biomarkers from hypoglycemic diabetic patients with either type 1 or type 2 diabetics and from control patients with type 1 or type 2 diabetes who didn't have hypoglycemia in the last 72 hours.
- Trial name
- NCT06652867
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Type1diabetes
Exercise Training and Endothelial Function in Type 1 Diabetes
Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological…
- Trial name
- EVaDia (NCT03528226)
- Testing
- Exercise Training Procedure, Normal life procedure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Lille
Diabetes, Diabetes Mellitus, Type 1
The Impact of Initiating/Switching to Insulin Detemir on Emotional Well-being and Treatment Satisfaction
This study is conducted in Europe. The aim of this study is to assess the well-being of patients following treatment with insulin detemir (Levemir®) in subjects with type 1 or type 2 diabetes in whom either initiation of or a…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- CONFIDENCE (NCT01542476)
- Testing
- insulin detemir
- Where
- Netherlands
- Volunteers
- 299 people
- Sponsor
- Novo Nordisk A/S
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