Clinical trials: Type I Diabetes Mellitus
Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle
Diabeloop for Highly Unstable Type 1 Diabetes
Feasibility study, comparing experimental treatment (DBLHU closed-loop system) with reference treatment (Low Glucose Predictive Suspend system) in 7 patients going through a series of N-of-1 trials.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle, Closed-Loop
- Trial name
- DBLHU (NCT04042207)
- Testing
- Low Glucose Predictive Suspend system, DBLHU System
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes, Sleep Apnea Syndrome
Sleep Apnea in Type 1 Diabetes
Sleep apnea syndrome is strongly associated to type 2 diabet, partly and this is partly due to obesity. Treatment of sleep apnea may improve hypertension, cardiovascular risk and in some studies diabetes status.
- Trial name
- DIASOM (NCT01935765)
- Testing
- Polysomnography, Evaluation of the autonomous nervous system, Clinical examination of the sleep
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes
Evaluation of Glycemic Control in Adults With Type 1 Diabetes When Switching to Insulin Degludec
Retrospective multicenter study analyzing data gathered from medical records and diabetes management platforms to assess the effect of using Insulin Degludec (Tresiba®) on measures of diabetes control.
- Trial name
- GLADE (NCT05434559)
- Testing
- Insulin Degludec
- Where
- 2 sites in Belgium
- Volunteers
- 475 people
- Sponsor
- prof dr Pieter Gillard
Diabetes, Diabetes Mellitus, Type 1 Diabetes
Argus 2.0 Adoption Study
This study evaluates the usability of the KOS Argus Continuous Glucose Monitoring (CGM) System, a noninvasive, wrist-worn device that estimates blood glucose levels using light-based sensors and artificial intelligence…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 2, Prediabetes
- Trial name
- NCT07425236
- Testing
- KOS Argus Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- KOS Inc.
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Diabetes Mellitus Type 1
A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics
This will be a prospective, randomized, double-blind, placebo controlled study. Patients with established Type 1 diabetes will be eligible for entry into the study.
- Trial name
- NCT02094534
- Testing
- ORMD-0801 Capsules
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oramed, Ltd.
Type 1 Diabetes Mellitus
Bone Marrow Autotransplantation in Type 1 Diabetes
This project evaluates the effectiveness of the administration of autologous bone marrow blood in patients with brittle type 1 diabetes mellitus to restore insulin secretion.
- Trial name
- NCT00821899
- Testing
- administration of autologous bone marrow blood
- Where
- 2 sites in Spain
- Volunteers
- 3 people
- Sponsor
- Hospital Clinic of Barcelona
Type 1 Diabetes
Identification of β Cell Dysfunction in Relatives of Individuals With Type 1 Diabetes Mellitus
Despite the valuable information derived from older studies evaluating type 1 diabetes, the diabetes research community has, in large part, overlooked potential contributions of baseline abnormalities in β cell function to T1D…
- Trial name
- NCT04362917
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Safety and Tolerability of EGT0001474 in Healthy Volunteers
Study to Determine the Safety, Tolerability, and Pharmacokinetic (PK) Profile of EGT0001474 in Healthy Volunteers
This study evaluated the safety, tolerability and pharmacokinetics of single or multiple doses of EGT0001474.
- Trial name
- NCT00854113
- Testing
- EGT0001474
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Theracos
Diabetes Mellitus
Safety Comparison of Pioglitazone and Glyburide in Type 2 Diabetes Subjects With Mild to Moderate Congestive Heart Failure
The purpose of this study is to compare the safety of Pioglitazone, once daily (QD), to Glyburide in Type 2 Diabetes Subjects with Mild to Moderate Congestive Heart Failure
- Trial name
- NCT00521820
- Testing
- Pioglitazone, Glyburide
- Volunteers
- 518 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 1, Autoimmune Diseases
Study to Evaluate the Safety and Feasibility of Diamyd® in Individuals at Risk for Type 1 Diabetes
A 2-arm randomized Phase II Open Label Study to evaluate the safety and feasibility of intralymphatic administration of Diamyd® (Diamyd) also known as retogatein in individuals at risk of Type 1 diabetes carrying the HLA DR3-DQ2…
- Conditions
- Diabetes Mellitus, Type 1, Autoimmune Diseases, Prevention
- Trial name
- NCT05683990
- Testing
- Diamyd
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Diamyd Medical AB
Type 1 Diabetes
Benefits of Smart Pens in Type 1 Diabetes
This study aims to address persistent challenges in achieving recommended control goals for patients with type 1 diabetes through innovative interventions.
- Trial name
- NCT06415097
- Testing
- Insulin Smart Pen
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Hypoglycemia, Diabetes Mellitus, Type 1
The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes
Objective: Because many people with type 1 diabetes drink ethanol and because glucagon is used to treat mild hypoglycaemia, it is essential to determine whether ethanol will impair the effectiveness of glucagon to increase…
- Trial name
- ALCO1 (NCT02881060)
- Testing
- Alcohol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Type 1 Diabetes Mellitus, Vitamin D Deficiency
Vitamin D Supplementation and Glycemic Control Improvement Among Type 1 Diabetic Children
Type 1 diabetes mellitus (T1DM) is an immune-mediated disease characterized by diminished insulin secretion due to damage to islets of Langerhans in the pancreas, which eventually results in high levels of glucose in the blood.
- Trial name
- NCT05141968
- Testing
- vitamin D supplements (2000 IU/day)
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Type 2 Diabetes, Type 1 Diabetes
NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes
Nutrition insecurity (inclusive of food insecurity + poor diet quality) is a fundamental social need that must be addressed to improve treatment and health outcomes for high-risk pregnant women with pregestational type 1 and 2…
- Conditions
- Type 2 Diabetes, Type 1 Diabetes, Pregnancy, High Risk
- Trial name
- NOURISH (NCT07560813)
- Testing
- Mid-Ohio Food Farmacy (MOF+) produce delivery, Nutrition education with Dining with Diabetes (DWD), Health Impact Ohio Central Ohio Pathways Hub to address unmet social needs
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Ohio State University
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes (T1D)
Clinican BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes
Youth with public insurance underutilize diabetes care, particularly diabetes technology which is associated with improvement in diabetes-specific outcomes.
- Trial name
- BEAD-T1D (NCT07491471)
- Testing
- Intervention to increase diabetes technology prescriptions
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes
Resistance Exercise in Already-active Diabetic Individuals (READI) Trial
The purpose of the READI tiral is to examine the effects of resistance training (weight training) on the blood sugar control of aerobically active individuals with Type 1 Diabetes.
- Trial name
- NCT00410436
- Testing
- Resistance Exercise
- Where
- 3 sites in Canada
- Volunteers
- 131 people
- Sponsor
- Ottawa Hospital Research Institute
Diabetic Neuropathy, Cognitive Impairment
Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus
Given that the tocotrienols have been shown to possess neuroprotective effects and that both type 1 and type 2 diabetes can lead to peripheral neuropathy and cognitive impairment, the present study aims to determine the…
- Trial name
- VENUS (NCT01973400)
- Testing
- Tocotrienol
- Where
- Malaysia
- Volunteers
- 300 people
- Sponsor
- Universiti Sains Malaysia
Diabetes
Multi-day (3) In-patient Evaluation of Intradermal Versus Subcutaneous Basal and Bolus Insulin Infusion
The primary objective of this study is to investigate if intradermal (in the skin) basal and bolus insulin delivery of a fast acting insulin analog (NovoRapid) as needed to adequately control the blood glucose for a subject with…
- Trial name
- NCT01557907
- Testing
- Subcutaneous delivery via Medtronic Quick-Set, Intradermal delivery via the BD Research Catheter Set
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Becton, Dickinson and Company
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