Clinical trials: Type I Diabetes Mellitus
Diabetes Mellitus, Type 1
Exercises on Children and Adolescents With Type 1 Diabetes Mellitus (T1DM)
This study aimed to assess the effect of aerobic and resistance exercise on postprandial blood glucose levels in children and adolescents aged 10 - 18 years, diagnosed with type 1 diabetes mellitus (T1DM) for at least 1 year…
- Trial name
- NCT06680557
- Testing
- Aerobic and resistance exercises
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Sohag University
Diabetes Mellitus, Type 1
Cardiac Dysfunction in Adolescents With Type 1 Diabetes: Contribution of Daily-life Glucoregulation and Impact on Cardiorespiratory Exercise Capacity
During the course of type 1 diabetes mellitus (T1DM), several complications can occur. One of these is the development of diastolic and systolic dysfunction (even in the absence of ischemic, valvular or hypertensive heart…
- Trial name
- GIIADMT1 (NCT04052919)
- Testing
- Cardiac dysfunction in adolescents with type 1 diabetes
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Hasselt University
Type 1 Diabetes, Hypoglycemia
Low-dose Glucagon for Prevention of Exercise-Induced Hypoglycemia in People With Type 1 Diabetes
The primary aim of the study is to compare the efficacy of single-administration low-dose glucagon and split-administration low-dose glucagon to placebo for prevention of exercise-induced hypoglycemia in people with type 1…
- Trial name
- NCT05076292
- Testing
- GlucaGen, Saline
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
An Indian Post Marketing Study of Mealtime Insulin, Fiasp®, to Evaluate Its Safety and Effectiveness in Patients With Diabetes Mellitus in Routine Clinical Practice
This study is to investigate the effects of Fiasp®, a mealtime insulin, in patients with diabetes mellitus. The purpose of this study is to collect information about Fiasp®, which is prescribed to the participants by their…
- Trial name
- NCT03987802
- Testing
- Faster-acting insulin aspart
- Where
- 36 sites in India
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
- Trial name
- SAFEGUARD (NCT07187531)
- Testing
- High Dose SAB-142, Low Dose SAB-142
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 159 people
- Sponsor
- SAb Biotherapeutics, Inc.
Type 1 Diabetes Mellitus
Omnipod Horizon™ Automated Glucose Control System Preschool Cohort
Subjects will undergo a 14-day outpatient, standard therapy phase during which sensor and insulin data will be collected. This will be followed by a 94-day (13-week) hybrid closed-loop phase conducted in an outpatient setting…
- Trial name
- NCT04476472
- Testing
- Omnipod Horizon™ Automated Glucose Control System
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Insulet Corporation
Diabetes Mellitus, Type 1
Assessment of an Automatic Closed-loop Insulin Delivery System
The overall aim of this research proposal is to determine the safety, feasibility and efficacy of an automatic closed-loop insulin delivery system.
- Trial name
- NCT02366767
- Testing
- Automatic closed-loop insulin delivery, Control
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Type 1 Diabetes, Diabetic Retinopathy
Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark
The objective of this study is to clarify the current diabetic status, including development of complications, in a nationwide cohort of type 1 diabetics, who were last examined together in a large study in 1995.
- Trial name
- DCPD1987 (NCT01785667)
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- Odense University Hospital
Blood Glucose Decrease During and After Defined Individual Exercise in T1DM
Exercise in Type 1 Diabetes Mellitus
Background: During and after exercise there is a twofold stimulation of glucose transporter type 4 in type 1 diabetes mellitus (T1DM) caused by an exogenous insulin injection and muscle contraction.
- Trial name
- ExT1DM (NCT02075567)
- Testing
- Experimental
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Kidney Disease, Type 1 Diabetes Mellitus
A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes
Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly, and type 1 diabetes.
- Trial name
- FINE-ONE (NCT05901831)
- Testing
- Finerenone
- Where
- 79 sites in United States, Canada and 7 more
- Volunteers
- 242 people
- Sponsor
- Bayer
Diabetes Mellitus
A Study of DIA:CONN P8 Smart Insulin Pen With CGM-Based Coaching in Patients With Type 1 or Type 2 Diabetes
A Study of DIA:CONN P8 Smart Insulin Pen With CGM-Based Coaching in Patients With Type 1 or Type 2 Diabetes
- Trial name
- NCT07004153
- Testing
- Smart Coaching Insulin Pen
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- G2e Co., Ltd
Type 1 Diabetes
Ketoacidosis in Individuals With Type I Diabetes Mellitus (T1DM)
The purpose of this study is to investigate individuals with type 1 diabetes who were disconnected from their insulin pump and insulin therapy was started again after positive ketones (U) in the urine or blood β-hydroxybutyrate.
- Trial name
- NCT00970567
- Testing
- Different insulin therapy at different time points
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 1
Controlled Insulin Delivery: Combining Technology With Treatment
Hypothesis: Closed-loop control systems for an artificial pancreas using multi-parametric model predictive control can be developed and evaluated safely in patients with Type 1 Diabetes Mellitus (T1DM) to control blood glucose…
- Trial name
- NCT01484457
- Testing
- Closed-loop session
- Where
- 2 sites in United States, Israel
- Volunteers
- 19 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
Fault Detection, Zone MPC and DiAs System in T1D
This is a randomized crossover study testing the efficacy of the Fault Detection algorithms using the Zone MPC algorithm and DiAs artificial pancreas platform in adult patients with type 1 diabetes.
- Trial name
- ZoneMPC (NCT02773875)
- Testing
- Artificial pancreas system (Algorithm + CGM + pump)
- Volunteers
- 20 people
- Sponsor
- Rensselaer Polytechnic Institute
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format
In previous studies, we tested the feasibility of a bi-hormonal closed loop system. This system for automated control of blood glucose in patients with type 1 diabetes was tested in the clinical research center as well as at the…
- Trial name
- APPEL4 (NCT02160275)
- Testing
- Artificial Pancreas (Inreda Diabetic BV), Insulin pump therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- J.H. DeVries
Diabetic Kidney Disease, Diabetic Nephropathy
A Study in Participants With Diabetic Kidney Disease
The purpose of this study is to determine if LY2382770 is safe and effective at protecting kidney function in participants with kidney disease due to diabetes.
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathy, Diabetic Glomerulosclerosis
- Trial name
- NCT01113801
- Testing
- LY2382770
- Where
- 78 sites in United States, Australia and 5 more
- Volunteers
- 417 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
The Effect of Endogenous GLP-1 on Glucagon Secretion in Type 1 Diabetes
Type 1 diabetes is a serious and burdensome disease that carries the risk of severe complications and premature death, partly due to low blood sugar, also called hypoglycaemia.
- Trial name
- EX-HYPO (NCT07373236)
- Testing
- exendin(9-39)amide, Saline (0.9% NaCl)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Asger Lund, MD
Kidney Failure, Chronic, Diabetes Mellitus, Type 1
Vascular Reactivity in Kidney Disease Patients
Dialysis patients suffer from many problems with blood vessels and this is even more so for patients with the added complication of diabetes.
- Conditions
- Kidney Failure, Chronic, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00226902
- Testing
- Changing hemoglobin concentration
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Melbourne Health
Type 1 Diabetes
The Management of Glucose Control and Hypoglycemic Prevention Using Continuous Glucose Monitoring System in Patients With Type 1 Diabetes
This study was designed to evaluate the glucose control and hypoglycemic prevention effect of using continuous glucose monitoring system(CGMS) in patients with type 1 diabetes.
- Trial name
- NCT04684030
- Testing
- Continuous glucose monitoring system(CGMS), Self-monitoring of blood glucose (conventional fingerpricking method)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Type I Diabetes Mellitus With Ulcer, Type II Diabetes Mellitus With Ulcer
Safety Study of Stem Cells Treatment in Diabetic Foot Ulcers
Diabetes Mellitus (DM) can be regarded as one of the "epidemics" of the western world. DM contributes to severe morbidity and mortality due to damage in the target organs (neuropathy, vasculopathy, nephropathy, retinopathy).
- Trial name
- NCT01686139
- Testing
- ABMD-MSC
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Sheba Medical Center
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