Clinical trials: Type2 Diabetes
Obesity & Overweight, Prediabetes / Type 2 Diabetes
Blood-based sEV Proteins for Early Detection of 2 Diabetes
The prevalence of diabetes in China is a significant concern. In 2019, 116.4 million adults were living with diabetes, a number expected to climb to 147.2 million by 2045. Type 2 diabetes (T2D) constitutes 95% of these cases .
- Trial name
- sEV-T2D (NCT07728591)
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Healthy, Type 2 Diabetes
Endogenous GLP-1 Secretion on Islet Function in People With and Without Type 2 Diabetes
GLP-1 is a hormone made by the body that promotes the production of insulin in response to GLP-1 is produced within the islets expressing prohormone convertase 1/3eating.
- Trial name
- NCT04466618
- Testing
- Saline, Exendin-9,39, Saline + Intralipid/Heparin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Adrian Vella
Diabetes Type 2, Diabetes Mellitus
Evaluating Use of Continuous Glucose Monitors in a Short-term 2x2-Crossover Study
This 5-week, double-blind, placebo-controlled, 2x2 crossover pilot study investigate the potential of collecting robust, real-time clinical study measures of glucose levels using Abbott Freestyle Libre Continuous Glucose…
- Trial name
- NCT04424888
- Testing
- WB-011, Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pendulum Therapeutics
Hepatocellular Carcinoma, Type 2 Diabetes
Role of LncRNA H19 in The Regulation of IGF-1R Expression
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. In Egypt, it is the most common cause of mortality and morbidity-related cancer.
- Conditions
- Hepatocellular Carcinoma, Type 2 Diabetes, Cancer
- Trial name
- NCT04767750
- Testing
- Blood sample collection
- Where
- 2 sites in Egypt
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Renal Failure Chronic Requiring Hemodialysis, Metabolic Syndrome
Salusin-alpha - a New Factor in the Pathogenesis of Lipid Abnormalities in Hemodialysis Patients
Hyperlipidemia and atherosclerosis lead to cardiovascular diseases and are an indirect cause of increased death rate in the general population.
- Conditions
- Renal Failure Chronic Requiring Hemodialysis, Metabolic Syndrome, Diabetes Mellitus Type 2, Hyperlipidemia
- Trial name
- NCT01448174
- Testing
- Atorvastatin
- Where
- Poland
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Type 2 Diabetes Mellitus
Investigating the Acute Effect of Alternative Forms of Physical Activity in a Multi-ethnic Population
The amount of people with diabetes has now reached over 4 million in the United Kingdom. Type 2 Diabetes accounts for the majority of all cases of diabetes and increases the risk of many other diseases, such as heart disease.
- Trial name
- NCT03549390
- Testing
- Physical activity
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Type 2 Diabetes, HbA1c
Daily Protein Pacing Effects on HbA1c in Type 2 Diabetics
This study will examine the effects of protein (whey) supplementation added to the normal diet of pre-diabetes or diagnosed type 2 diabetes mellitus (T2DM) men and women on plasma glycated hemoglobin (HbA1c) and total body fat…
- Conditions
- Type 2 Diabetes, HbA1c, Protein Intake
- Trial name
- NCT05355090
- Testing
- PP
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Diabetes Mellitus, Non-Insulin-Dependent
NNC 90-1170 Mechanism of Action: A Double-Blind, Randomized, Single-Center, Placebo-Controlled, Crossover Study to Examine Beta-Cell Responsiveness to Graded Glucose Infusion in Subjects With Type 2 Diabetes
The purpose of this research study is to investigate the mechanism of action of a new investigational medication (drug), NNC 90-1170, which is being developed for the treatment of type 2 diabetes (adult onset type of diabetes.
- Trial name
- NCT00013910
- Testing
- NNC 90-1170
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Polyneuropathies, Diabetic Complications Neurological
Is Serum Irisin Level a Biomarker in Diabetic Polyneuropathy?
Diabetic polyneuropathy is a common complication of type 2 diabetes mellitus associated with sensory impairment and functional disability. Irisin is a myokine that has been implicated in glucose metabolism and neuroprotection.
- Conditions
- Polyneuropathies, Diabetic Complications Neurological, Diabetes Mellitus Type 2
- Trial name
- NCT07734597
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- GÜLDEN ANATACA
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Primary Disease: 1. Type 2 Diabetes
Culinary Medicine vs. Nutrition Education in Diabetes
This pragmatic trial compares the effectiveness of virtual culinary medicine classes vs. standard of care medical nutrition visits to improve glycemic control in patients with uncontrolled type 2 diabetes .
- Trial name
- NCT05019274
- Testing
- Culinary Medicine Intervention, Standard of Care Nutrition Visits
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Healthy People, Diabetes Mellitus, Type 2
The Effects of Mixed Grain on Blood Glucose and Insulin in Healthy Male
This study was an open, 4-treatment, 5-sequence, 5-day cross-over randomized design clinical trial to evaluate the efficacy of mixed grain on blood glucose, insulin and Glycemic index(GI) in healthy males.
- Trial name
- NCT01840982
- Testing
- Mixed grain 1, Mixed grain 2, White rice
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Type 2 Diabetes
Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota
Accumulating evidence suggests that bile acids and bacteria in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis.
- Trial name
- NCT02061124
- Testing
- Sevelamer 1600 mg TID for 7 days
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide
Many patients with type 2 diabetes also have conditions that are treated with diuretics. The patients may also be treated with GSK189075 for their diabetes.
- Trial name
- NCT00671424
- Testing
- Hydrochlorothiazide (HCTZ), Remogliflozin etabonate (GSK189075), Furosemide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabete Type 2, Pre Diabetes
Investigation of PJ vs. Sugar on Glucose Levels in Healthy and Prediabetic Subjects
Pomegranate fruits and products, including juice, tea, wine and extracts are widely consumed and recognized for their health benefits.
- Trial name
- PSW (NCT04591782)
- Testing
- PomJuice, Water, Sugar Water
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity, Adiposity
GIP/GLP-1 Co-Activity in Subjects With Obesity: Lowering of Food Intake
We aim to delineate the effects of separate and combined infusion of GIP and GLP-1 on food intake, appetite, bone health and fat metabolism in overweight/obese subjects.
- Conditions
- Obesity, Adiposity, Type 2 Diabetes
- Trial name
- GASOLIN (NCT02598791)
- Testing
- IIGI+GIP, IIGI+GLP-1, OGTT
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2
OXEMET™ 1000 mg Coated Tablets (Metformin Hydrochloride) Bioequivalence Study. OXEMET (TM) is a Trademark of the GlaxoSmithKline Group of Companies. GLAFORNIL(TM) is a Trademark of Merck.
This is an open-label, single-center, randomized, 2-way crossover study to evaluate the bioequivalence of OXEMET™ 1000 mg coated tablets, relative to 1000 mg of the reference product administered as two 500 mg tablets, under…
- Trial name
- NCT01842620
- Testing
- Metformin
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus With Periodontal Disease
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus doxycycline on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02845024
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Diabetes Mellitus, Type 2 Diabetes Mellitus
Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)
This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes. The study population will include individuals with known diabetes, and controls without diabetes.
- Trial name
- NCT01172743
- Where
- Qatar
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Type II Diabetes Mellitus
Pharmacokinetics and Safety/Tolerability Profile of CKD-379
A study to compare the pharmacokinetics and safety/tolerability between CKD-379 tablet and D759, D745, D150 combination
- Trial name
- NCT05452525
- Testing
- CKD-379 I, CKD-379 II, D759+D745+D150
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
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