Clinical trials: Ulcer, Leg
Diabetic Foot Ulcers, Osteomyelitis
UT Southwestern Diabetic Foot Ulcers (DFU) and Osteomyelitis (DFO) Recruitment Database, Data and Tissue Repository
This will be a continuing, prospective study of diabetic foot ulcers and infections, risk factors and clinical outcomes and a limited data set conducted by the investigator through the establishment of a data and tissue…
- Trial name
- DFUDatabase (NCT02463500)
- Testing
- DFU
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot
Wound Bed Preparation for Diabetic Foot Ulcers
The study objective was to compare the efficacy of NPWT versus alginates dressings on the wound bed preparation prior to STSG surgery, as well as investigating the underlying mechanisms.
- Trial name
- NCT05577104
- Testing
- Negative pressure wound therapy (NPWT), conventional moist dressings
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ulcer Healing, Diabetic Foot Ulcer
Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers
The goal of this clinical pilot is to collect patient outcome data on a commercially available, keratin-based skin substitute matrix: ProgenaMatrix®.
- Trial name
- NCT05797285
- Testing
- human keratin graft
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- ProgenaCare Global, LLC
Diabetic Foot Ulcer, Pseudomonas Aeruginosa Infection
Bacteriophage Therapy TP-102 in Diabetic Foot Ulcers
This is a Phase I/IIa trial designed to evaluate topical bacteriophage therapy in patients with diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Pseudomonas Aeruginosa Infection, Staphylococcus Aureus Infection, Acinetobacter Infection
- Trial name
- REVERSE (NCT04803708)
- Testing
- TP-102
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Technophage, SA
Peripheral Arterial Disease, Diagnosis
DIAbetes Maximal ACCeleration
Prevalence of diabetes mellitus (DM) is increasing rapidly, with patient numbers projected to rise to 643 million by 2030. As a consequence of diabetes-related atherosclerosis, peripheral arterial disease (PAD) and in particular…
- Conditions
- Peripheral Arterial Disease, Diagnosis, Diabetic Foot
- Trial name
- DIAMACC (NCT05646147)
- Testing
- Maximal Systolic Acceleration
- Volunteers
- 238 people
- Sponsor
- Leiden University Medical Center
Chronic Venous Leg Ulcers
Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy
Indication: Subjects with chronic venous leg ulcers Primary Objective: To evaluate the efficacy of bio-electrical stimulation therapy in the healing of chronic venous leg ulcers Secondary Objective(s): To evaluate the percentage…
- Trial name
- NCT00678847
- Testing
- KFH NOVO (inactive) + SCT, KFH Novo (BEST) + SCT
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Kingfisher Healthcare
Venous Leg Ulcer
A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers
The objective of this study is to assess the efficacy and safety of VitroGro® combined with standard care in the treatment of Venous Leg Ulcers (VLUs) compared to Placebo with standard care over the course of the 8-week treatment…
- Trial name
- NCT01982318
- Testing
- VitroGro® ECM, Dulbecco's Phosphate Buffered Saline
- Sponsor
- Tissue Therapies Ltd.
Critical Limb Ischemia, Diabetic Foot
Autologous Peripheral Blood Mononuclear Cells in Diabetic Foot Patients With No-option Critical Limb Ischemia
The objective of this trial is to determine whether PBMNCs in diabetic patients with critical, non revascularizable limb ischemia can prevent major amputation and affect mortality and healing.
- Trial name
- NCT04255004
- Testing
- Pall Celeris System, point of care device for human cell therapy
- Volunteers
- 76 people
- Sponsor
- Ospedale San Donato
Diabetic Foot Ulcer
Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers
Assess the effect of iontophoresis of treprostinil on wound closure over 12 weeks, in patients with DFU. In the present study the investigators aim at establishing the proof-of-concept of iontophoresis of treprostinil as a…
- Trial name
- InTREPiD (NCT03654989)
- Testing
- Treprostinil iontophoresis
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble
Venous Leg Ulcer
Clinical Study to Assess Efficacy and Safety of a New Compression System in the Management of Venous Leg Ulcers
The primary objective of this study is to demonstrate the non-inferiority of the 2-layer compression system Kit Biflex® with regard of the 4-layer compression system PROFORE® in the treatment of venous leg ulcers in terms of…
- Trial name
- COMPULCE (NCT02782689)
- Testing
- Kit Biflex, Profore
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Thuasne
Genetic Predisposition to Disease, Inflammation
Gene Expression in Chronic Venous Leg Ulcers
Chronic Venous Disease (CVD) is a widespread clinical condition widely spread in the western countries that may negatively impact the quality of life (QoL) of affected patients.
- Conditions
- Genetic Predisposition to Disease, Inflammation, Venous Leg Ulcer
- Trial name
- GECVELUS (NCT05134597)
- Testing
- Genetic assessment
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Diabetic Foot Ulcer, Diabetes Mellitus, Type 2
Effects of a Exercise Program on Health Outcomes in People With Diabetic Foot Ulcers
People with diabetes are at risk for life altering complications, including diabetic foot ulcers. To heal a diabetic foot ulcer, people are often required to refrain from bearing weight on their affected limb for months.
- Trial name
- NCT03002155
- Testing
- EnhanceFitness community exercise program
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Venous Ulcers
Treatment of Cutaneous Ulcers With a Novel Biological Dressing
The aim of the study is to evaluate the effect of a biological dressing on the healing process of venous ulcers. The dressing is a reconstructed skin substitute made with the patients own cells.
- Trial name
- NCT00207818
- Testing
- self assembled skin substitute (SASS)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- CHU de Quebec-Universite Laval
Diabetic Foot Ulcer
Improving DFU Outcomes: Early Detection of Foot Ulcers Using Novel Technology
The investigator team will study the adherence of the participant cohort to a non significant risk device over a six month period.
- Trial name
- DFUMAT (NCT05968924)
- Testing
- Podimetrics SmartMat
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Chronic Wounds, Burns
THERAVEX Tissue Care Spray Plus for the Management of Cutaneous Wounds, Burns, and Chronic Ulcers
Pilot observational clinical evaluation assessing the safety and potential effectiveness of THERAVEX Tissue Care Spray Plus as an adjunctive topical therapy for the management of cutaneous wounds, burns, traumatic lesions…
- Conditions
- Chronic Wounds, Burns, Pressure Ulcer, Traumatic Wounds
- Trial name
- NCT07617961
- Testing
- THERAVEX TISSUE CARE SPRAY PLUS
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Biointelligent Technology Systems SL
Diabetic Foot Ulcer
Laser Therapy for At-Home Treatment of Diabetic Foot Ulcers - Canada
The global prevalence of diabetes is on the rise and with it increase in prevalence of diabetic foot ulcers (DFU). These recalcitrant wounds are difficult to manage and pose a heavy economic burden.
- Trial name
- LLL&DIAB-02 (NCT03687580)
- Testing
- B-Cure Laser Pro
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Scarborough Rouge Hospital
Hard-to-heal Wounds, Diabetic Foot Ulcer
Clinical Investigation of Sorbact® Dressings
The main purpose of this exploratory clinical investigation is to study the binding of bacteria and fungi from hard-to-heal wounds to the DACC-coated dressings.
- Conditions
- Hard-to-heal Wounds, Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
- Trial name
- NCT05089890
- Testing
- Sorbact® Compress, Sorbact® Gel Dressing, Sorbact® Ribbon Gauze
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- ABIGO Medical AB
Diabetic Foot Ulcer
Assessment of the Clinical, Cellular and Molecular Effects of Royalactin-Royal Jelly on the Healing of Wagner Grad II Diabetic Foot Ulcers.
The aim of this study is to evaluate the clinical, cellular, and molecular effects of Royalactin as an adjunct to standard treatment, compared to standard treatment alone, in the treatment of Wagner grade II diabetic foot ulcers…
- Trial name
- ROYALACIN (NCT07509268)
- Testing
- Royalactina
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Venous Ulcers
Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care
The purpose of this study is to evaluate the effectiveness of a multilayer compression bandage (two layers), compared with the crepe bandage, on healing of venous leg ulcers, in patients attended in nursing Primary Care Health…
- Trial name
- NCT02364921
- Testing
- Two multilayer compression bandage, Crepe bandage
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
Chronic Ulcer of Leg or Foot, Diabetic Foot Ulcer
MAtrix Therapy for Hard-to-heal ChrOnic Wounds
CACIPLIQ20® is currently a class III CE marked medical device available in various European and non-European countries, and currently primarily used in managing hard-to-heal wounds.
- Conditions
- Chronic Ulcer of Leg or Foot, Diabetic Foot Ulcer, Arterial Ulcer, Venous Ulcer of Leg
- Trial name
- MATHCOW (NCT05170984)
- Testing
- CACIPLIQ20®
- Where
- France
- Volunteers
- 191 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement