Clinical trials: Ulcer Venous
Ulcer
Calcium Dobesilate for Chronic Venous Wounds
The objective of the study is to assess the efficacy of calcium dobesilate for treating chronic venous wounds. The hypothesis is that venous ulcers treated with standards measures (compressive measures) and calcium dobesilate…
- Trial name
- NCT00979836
- Testing
- Calcium Dobesilate
- Where
- 42 sites in Spain
- Volunteers
- 230 people
- Sponsor
- Fundacion Iberoamericana Itaca
Venous Ulcer
Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers
The purpose of this study is to compare the effectiveness of standard venous ulcer care to standard venous ulcer care plus a cell based product made from the patients own blood.
- Trial name
- NCT00273234
- Testing
- Autologous Platelet Gel (APG)
- Where
- 6 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Healing Corporation
Leg Ulcer
A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers
This is a randomized (1:1), prospective, open label, multicenter, comparative study to be examine the effectiveness of Collagen-ORC Antimicrobial matrix, a new wound dressing, on venous leg ulcers.
- Trial name
- NCT00235209
- Testing
- Collagen ORC Antimicrobial Matrix (CAM)
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ethicon, Inc.
Venous Leg Ulcer, Mixed Leg Ulcer
Leg Ulcers Standards of Care Enhancement
Multi-center, prospective,randomized controlled study on the speed of healing, life quality and cost-effectiveness of the treatment with a blue light medical device (EmoLED) versus existing Standards Of Care (SOC) for patients…
- Trial name
- LUCE (NCT04689009)
- Testing
- EmoLED, current Standards Of Care
- Where
- 5 sites in Italy
- Volunteers
- 83 people
- Sponsor
- Emoled
Wounds and Injuries
Study to Evaluate Polyheal-1 in Treatment of Recalcitrant Wounds
The objective of this study is to evaluate the performance of Polyheal-1 compared to Saline in the treatment of recalcitrant wounds including venous, post-operative and post-traumatic chronic wounds with different etiologies…
- Trial name
- NCT00552643
- Testing
- Suspension of polystyrene beads (POLYHEAL 1), Saline (0.9% NaCl)
- Where
- 6 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Polyheal Ltd.
Hard-to-heal Wounds, Venous Leg Ulcer (VLU)
Laser Photobiomodulation for Hard-to-heal Ulcers in Frail Older Adults
The aim of this quasi-experimental prospective study is to evaluate the effectiveness of photobiomodulation treatment on hard-to-heal ulcers of various diagnosed aetiologies in frail older adults, admitted to municipal home…
- Conditions
- Hard-to-heal Wounds, Venous Leg Ulcer (VLU), Arterial Leg Ulcer, Pressure Ulcer (PU)
- Trial name
- NCT07520825
- Testing
- Photobiomodulation, Standard-of-care ulcer dressing
- Where
- Sweden
- Volunteers
- 1,290 people
- Sponsor
- Umeå University
Venous Leg Ulcer
Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel
The primary objective of the study is to evaluate the efficacy of Prontosan® Wound Irrigation Solution and Prontosan® Wound Gel in the treatment of hard-to heal venous leg ulcers compared to control saline irrigation solution and…
- Trial name
- NCT01153633
- Testing
- Prontosan Wound Irrigation Solution and Prontosan Wound Gel
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- B. Braun Ltd. Centre of Excellence Infection Control
Chronic Wounds, Diabetes
FGF-1 for Topical Administration for the Treatment of Diabetic or Venous Stasis Ulcers
FGF-1 is being used for the treatment of patients with diabetic or venous stasis ulcers. Procedure includes topical administration of FGF-1 or placebo and evaluation of safety, pharmacokinetics, and wound improvement.
- Conditions
- Chronic Wounds, Diabetes, Venous Stasis Ulcers
- Trial name
- NCT00425178
- Testing
- FGF-1
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Venturis Therapeutics, Inc.
Trophic Ulcers, Chronic Venous Insufficiency
LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency
The aim of this study was to evaluate comparatively the efficiency of traditional treatment methods in patients with chronic venous diseases of C6 class, and a new combined low level laser therapy (LLLT) by LASMIK device.
- Trial name
- NCT03104985
- Testing
- LASMIK, Conventional therapy
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Research Center Matrix
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Safety and Preliminary Efficacy of TrophiPatch, an Adipose-Derived Stromal Cell Patch for Chronic Leg Ulcers
This study aims to evaluate the safety and effectiveness of an experimental biological dressing called TrophiPatch, applied to adults with chronic leg ulcers of diabetic or vascular orign.
- Trial name
- RESCUE-PATCH (NCT07048054)
- Testing
- TrophiPatch: allogeneic adipose-derived stromal cell patch
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Nicolò Brembilla
Venous Leg Ulcers
Safety Evaluation of the KLOX BioPhotonic System in Venous Leg Ulcers
The primary objective of these case series is to evaluate the safety and tolerability of the KLOX BioPhotonic System as adjunctive therapy to Standard Of Care (SOC) in patients with venous leg ulcers.
- Trial name
- NCT02222467
- Testing
- KLOX BioPhotonic System
- Where
- 4 sites in Canada
- Volunteers
- 10 people
- Sponsor
- KLOX Technologies Inc.
Skin Ulcer Venous Stasis Chronic
Allogeneic ABCB5-positive Stem Cells for Treatment of CVU
The aim of this clinical trial is to investigate the efficacy (by monitoring the wound size reduction of Chronic Venous Ulcers) and safety (by monitoring adverse events) of the medicinal product to be studied after two…
- Trial name
- NCT03257098
- Testing
- allo-APZ2-CVU
- Where
- 9 sites in Germany
- Volunteers
- 31 people
- Sponsor
- RHEACELL GmbH & Co. KG
Varicose Ulcer
Wound Dressings Adapted to Wound Exudate and Bacterial Load in Therapy Resistant Large Sized Leg Ulcers
The purpose of the study was to investigated if modern wound dressings adapting to wound exudation and the amount of bacterial colonization can heal large therapy resistant leg ulcers which had a pre-treatment with compresses…
- Trial name
- NCT00349700
- Testing
- Compression: 2 weeks four layer bandages, then stockings, debridement, Actisorb plus (r) + Trionic(r)/ Allevyn (r)
- Where
- Germany
- Volunteers
- 139 people
- Sponsor
- Ruhr University of Bochum
Venous Ulcer, Foot Ulcer, Diabetic
Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers
This study will compare the proportion of patients who have wound closure within 12 weeks as well as the time to wound closure in patients receiving Artacent™ versus standard of care for treatment of non-healing lower extremity…
- Trial name
- TMArtacent (NCT02838784)
- Testing
- Artacent Human Amniotic Membrane, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Tides Medical
Venous Leg Ulcer, Venous Insufficiency
The Effect of Manual Lymphatic Drainage
In venous ulcer, venous insufficiency is accompanied by lymphatic insufficiency. Manual lymphatic drainage (mld) technique cause to increase contraction rate of lymphatic collector and venous flow.
- Conditions
- Venous Leg Ulcer, Venous Insufficiency, Lymphatic Disease
- Trial name
- NCT04461132
- Testing
- Manual Lymphatic drainage (MLD), Skin Care, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Venous Leg Ulcer
VLU Non-Inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-Layer Bandaging
The purpose of the study is to test non-inferiority of chronic Venous Leg Ulcer (VLU) area reduction at 16 weeks with a dual action pneumatic compression device compared to multi-layer bandaging.
- Trial name
- NCT02680834
- Testing
- Dual Action Pneumatic Compression Device, Multi-Layer Bandaging
- Where
- 18 sites in United States
- Volunteers
- 56 people
- Sponsor
- Tactile Medical
Leg Ulcer
Study to Evaluate the Performance of AQUACEL® Extra™ in Venous Leg Ulcers
Based upon the in-vitro data AQUACEL® Extra™ achieves a 39% increase in absorbency. As such it is anticipated that through improved exudate management a longer wear time will be achieved in the AQUACEL® Extra™ group compared to…
- Trial name
- NCT01591434
- Testing
- AQUACEL®, AQUACEL® Extra™
- Where
- 12 sites in Germany, Netherlands and 2 more
- Volunteers
- 65 people
- Sponsor
- ConvaTec Inc.
Venous Stasis Ulcer, Quality of Patient Care
Venous Leg Ulcer and Lymphedema Registry
This is an observational, longitudinal real world registry of venous leg ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- VLULR (NCT02813187)
- Testing
- cellular and tissue based therapy, debridement, advanced wound therapy
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Post-Approval Study
This study is a prospective, multicenter, single-arm post-market clinical study to evaluate the GORE® VIABAHN® FORTEGRA Venous Stent in real-world use.
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT07538609
- Testing
- GORE® VIABAHN® FORTEGRA Venous Stent
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- W.L.Gore & Associates
Venous Ulcer
Immediate Versus Early Endovenous Ablation In Venous Ulcer
The study is conducted to assess the effects of immediately started foam sclerotherapy in venous ulcer compared to early intervention.
- Trial name
- NCT03795064
- Testing
- Foam sclerotherapy, Endothermal ablation
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Oulu University Hospital