Clinical trials: Ulcerative
Healthy Men and Subjects With Ulcerative Colitis
A Phase 1 Study of KHK4083 in Healthy Volunteers and Subjects With Ulcerative Colitis
The objectives of this study are to evaluate the safety and tolerability of a single intravenous (IV) or subcutaneous (SC) dose of KHK4083 in Japanese or White healthy men in a placebo-controlled, single-blind comparative study…
- Trial name
- NCT02985593
- Testing
- KHK4083
- Where
- Japan
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Inflammatory Bowel Diseases, Crohns Disease
Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort
Purpose: Inflammatory bowel disease patients undergoing treatment with varying biologic agents will be evaluated for incidences of paradoxical immune reactions, the risk factors associated with those paradoxical immune reactions…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Ulcerative Colitis, Colitis
- Trial name
- APRIL (NCT02503514)
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Stomach Ulcer
Influence of CYP2C19 Polymorphism on PK/PD of Omeprazole
A clinical trial to investigate the influence of CYP2C19 polymorphism on pharmacokinetic/pharmacodynamic characteristics of omeprazole in healthy Korean volunteers
- Trial name
- NCT02299687
- Testing
- Omeprazole
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Skin Wound
Dermal Regeneration Photosynthetic Matrix
The aim of the study is to demonstrate that dermal regeneration photosynthetic matrix applied in patients with acute clean skin wound is safe.
- Trial name
- HULK (NCT03960164)
- Testing
- Dermal regeneration photosynthetic matrix (DRPM)
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
IBD, Crohn Disease
Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) often leads to poor disease control and reduced quality of life. Changes in the gut microbiota may disrupt the energy metabolism of immune cells, contributing to IBD.
- Conditions
- IBD, Crohn Disease, Ulcerative Colitis (UC)
- Trial name
- ENERGISED (NCT07300553)
- Testing
- Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mg, Inulin/Inulin C13
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pressure Ulcer, Sleep Disorder
Adaptation of Mattresses Made With Different Materials to Personal Anthropometry Values and Body Postures
Sleep disorders affect 40% of the adult population each year and are often associated with morbidity and mortality (Kripke et al., 2002; F.-Z. Low et al., 2017).
- Conditions
- Pressure Ulcer, Sleep Disorder, Spine Degeneration, Body Structure, Altered From Its Original Anatomical Structure
- Trial name
- NCT05486039
- Testing
- Changing behaviour
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Inflammatory Bowel Diseases
The Bacterial Secretome in IBD
Secreted bacterial effectors produced by the intestinal microbiota are in part responsible for the proinflammatory effect of the fecal content in inflammatory bowel disease (IBD) patients.
- Trial name
- NCT04136587
- Testing
- Colonic fluid collection during endoscopy for analysis of the bacterial secretome
- Where
- Austria
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Gastritis Caused by Helicobacter Pylori
Effect of Chicken Egg Antibody (IgY) on Patients With Chronic Gastritis
H. pylori positive patient volunteers that passed the selection criteria are recruited and divided into a test and a control group.
- Trial name
- NCT02721355
- Testing
- GastimunHP
- Where
- Vietnam
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Immunology Research Institute in Gifu
Reflux Oesophagitis
Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers
The objectives of this study were: To compare repeated doses of YF476 at 2 dose levels, placebo and omeprazole with respect to their effect on basal- and food- stimulated gastric pH in healthy volunteers.
- Trial name
- NCT01599858
- Testing
- YF476, Omeprazole
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
Chronic Ulcer, Venous Ulcer
Efficacy of PICO Single-use System in Chronic Ulcers
A clinical trial will be carried out comparing the efficacy of PICO system based on negative pressure therapy (NPT) in adults with chronic ulcers compared to conventional treatments.
- Conditions
- Chronic Ulcer, Venous Ulcer, Diabetic Foot Ulcer, Pressure Injury
- Trial name
- NCT05877378
- Testing
- Single-use negative pressure therapy (PICO)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Canker Sore
Luminance RED for Canker Sores
Canker sores, also called aphthous ulcers, are small, shallow lesions that develop on the soft tissues in your mouth or at the base of your gums.
- Trial name
- NCT04914533
- Testing
- Luminance RED Low Level Laser Therapy Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ProofPilot
Gastroduodenal Ulceration
Evaluation of Upper GI Ulceration Induced by PL2200 Versus Aspirin in At-Risk Subjects
This trial is a Phase 2, randomized, controlled study to compare the degree of mucosal injury after the oral administration of an investigational product, PL2200, and a marketed 325 mg immediate-release aspirin product.
- Trial name
- NCT01646814
- Testing
- PL2200, Aspirin tablets
- Where
- 10 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- PLx Pharma
Pressure Injury, Wound
Pressure Injury Prediction and Education Model Using a Mobile Application System
Pressure injuries are common in the elderly and patients who reduced physical activities. Its complications significantly impact the health care system and social burden, even causing the death rate to be as high as 68%.
- Trial name
- NCT05357391
- Testing
- The Pressure Injury Prediction and Education model using a mobile application system
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Gastrointestinal Hemorrhage
The Clinical Feature of Ulcer Base Over Time After Prophylactic Argon Plasma Coagulation in Colonic EMR
The prophylactic APC right after colonic EMR doesn't mean the complete coagulation of visible vessel because of injection material.
- Trial name
- NCT02025764
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Ulcerative Colitis
Efficacy of Golimumab in Maintaining Deep Remission in UC Patients in Prolonged Remission With Infliximab
This study monitors the efficacy and safety of Golimumab in maintaining deep remission and quality of life in Ulcerative Colitis patients in deep prolonged remission with Infliximab.
- Trial name
- Switch (NCT02868398)
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Stomach Diseases
Diagnosis of Gastric Lesions From Exhaled Breath and Saliva
The investigators study the feasibility of a novel method in oncology based on breath analysis with a nanosensors array for identifying gastric diseases.
- Trial name
- NCT01420588
- Where
- 2 sites in China, Latvia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Ulcerative Colitis, Pouchitis
Clotrimazole Enemas for Pouchitis in Children and Adults
Colectomy with creation of an ileal pouch (IPAA) is now the treatment of choice for patients with ulcerative colitis that is resistant to existing medical therapies.
- Conditions
- Ulcerative Colitis, Pouchitis, Ileitis, Inflammatory Bowel Disease
- Trial name
- CAPTURE (NCT00061282)
- Testing
- Clotrimazole
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Web
Ulcerative Colitis
Impact of Fecal Microbiota Transplantation in Ulcerative Colitis
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. UC pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota (called dysbiosis) in…
- Trial name
- REBALANCE-UC (NCT03483246)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases, Crohn Disease
Identification of Predictive Biomarkers for Response to Biologic Therapies and Tofacitinib in Inflammatory Bowel Disease
Prospective, multicentre trial which the biologic treatment will be initiated by clinical indication. The treatment selection anti-TNFα (infliximab, adalimumab or golimumab), vedolizumab, ustekinumab and tofacitinib will be made…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- BioIBD (NCT03885713)
- Testing
- Infliximab or adalimumab or golimumab or vedolizumab or ustekinumab or tofacitinib
- Where
- 21 sites in Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Ulcerative Colitis
The Effects of Moxibustion on Ulcerative Colitis
To investigate the mechanism and effects of moxibustion on patients with ulcerative colitis.
- Trial name
- NCT02931162
- Testing
- Herb-partitioned moxibustion
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian