Clinical trials: Ulcerative
Non-healing Wound, Diabetic Foot Ulcer
Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound…
- Trial name
- NCT06028386
- Testing
- AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Arch Therapeutics
Esophagitis, Reflux, Esophagitis, Peptic
Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive Esophagitis
The purpose of this study is to assess the ability of once-daily (QD) treatment with Dexlansoprazole modified-release (MR) 60 mg and 90 mg and placebo in maintaining healing of erosive esophagitis (EE).
- Trial name
- NCT00255151
- Testing
- Dexlansoprazole MR
- Where
- 100 sites in United States
- Volunteers
- 451 people
- Sponsor
- Takeda
Incarcerated Hernia, Appendicitis Acute
Prevention of Postoperative Hernias in Emergency Surgery
The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery.
- Conditions
- Incarcerated Hernia, Appendicitis Acute, Cholecystitis, Acute, Ileus
- Trial name
- PROPHECY (NCT06815822)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Jan Kochanowski University
Peptic Ulcer
Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer
The purpose of this study is to compare the gastric acid suppression profile among different regimen (Oral Vs Intravenous)of administration of proton pump inhibitor - Esomeprazole by 24hours intragastric pH monitoring.
- Trial name
- NPH (NCT00471029)
- Testing
- esomeprazole
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital
Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion
Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention for Diabetic Foot Ulcers With Lower Extremity Arterial Occlusion
The goal of this clinical trial is to evaluate whether cold atmospheric plasma (CAP) combined with endovascular intervention can accelerate wound healing and improve safety outcomes in patients aged 18 to 80 years with diabetic…
- Trial name
- NCT07198061
- Testing
- Cold Atmospheric Plasma (CAP), Infrapopliteal Endovascular Revascularisation, Guideline-Based Standard DFU Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenyang Medical College
Diabetic Foot Ulcer, Infection
Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
This is an open label study of subjects who have failed Protocol PGN-1300. Adult subjects (greater than 18 years old) who present with a mildly infected diabetic foot ulcer (IDSA criteria) having full thickness (i.e., through the…
- Trial name
- NCT02119754
- Testing
- Plurogel PN
- Where
- 15 sites in United States
- Volunteers
- 15 people
- Sponsor
- PluroGen Therapeutics, Inc
Diabetic Foot, DFU
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
- Conditions
- Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- BIOCAMP (NCT07089602)
- Testing
- Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- BioLab Holdings
Peptic Ulcer
Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer
Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.
- Trial name
- NCT01138969
- Testing
- esomeprazole
- Where
- Taiwan
- Volunteers
- 165 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Chronic Non-healing Skin Ulcers
PRP Versus PRF Versus Conventional Treatment in Chronic Non-healing Skin Ulcers
To compare the therapeutic efficacy of PRP and PRF: two relatively newer modalities in the management of chronic non-healing ulcers versus conventional treatment.
- Trial name
- NCT06281483
- Testing
- platelet-rich plasma, platelet-rich fibrin, Surgical debridement, normal saline washing and dressing coverage
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Kafrelsheikh University
Inflammatory Bowel Disease (IBD), Medication Compliance
Telehealth Monitoring in Inflammatory Bowel Disease: Effects on Medication Compliance, Self-Efficacy, and Quality of Life
This randomized controlled trial aims to evaluate the effect of nurse-led telehealth monitoring on medication adherence, self-efficacy, and quality of life in individuals with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease (IBD), Medication Compliance, Quality of Life, Telehealth Monitoring
- Trial name
- NCT06971627
- Testing
- Nurse-led Telehealth Monitoring Program, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Colitis, Ulcerative
An Early Phase 2 Clinical Study of KSP-0243
A phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study to administer KSP-0243 or a placebo once daily after breakfast for 8 weeks in 100 patients with mild to moderate active ulcerative…
- Trial name
- NCT05831670
- Testing
- KSP-0243
- Where
- Japan
- Volunteers
- 108 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Diabetic Foot Ulcers (DFU), Nutrition Assessment
Nutritional Status in Adults With Diabetic Foot Ulcers
This feasibility and pilot study has two aims. The primary aim is to assess the feasibility of collecting clinical, nutritional, and functional data among adults with diabetic foot ulcers (DFUs) who are treated at an outpatient…
- Conditions
- Diabetic Foot Ulcers (DFU), Nutrition Assessment, Malnutrition (Calorie), Ulcer Foot
- Trial name
- NutriDFU-P (NCT07621770)
- Testing
- Protein supplementation and nutrition education
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
Unravelling Intestinal Fibrosis in Ulcerative Colitis
The main objectives are: (i) to identify candidate fibrotic cellular pathways in UC patients treated with a JAK inhibitor filgotinib), and (ii) to detect and monitor in vivo fibrosis in UC patients using FAPi-PET/CT imaging
- Conditions
- Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Fibroblast Activation Protein Inhibitor
- Trial name
- INTERACT (NCT06604273)
- Testing
- Fibroblast Activation Protein Inhibitor
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ulcerative Colitis
Prediction of Dietary Intervention Efficacy in Mild Ulcerative Colitis Patients Based on Fecal Microbiome Signatures
A double-blind randomized placebo-controlled parallel trial with two intervention arms and two placebo arms and a period of eight intervention weeks to validate the prediction that prebiotics could induce a higher response in…
- Trial name
- PREDUCTOME (NCT05579483)
- Testing
- Prebiotics
- Where
- Netherlands
- Sponsor
- Wageningen University
Diabetes Mellitus, Diabetic Peripheral Neuropathy
Immunonutrition for Diabetic Foot Ulcers
Diabetes-induced peripheral neuropathy can lead to the development of diabetic foot ulcers (DFUs), which can have a devastating effect on patients' lives and can lead to life threatening infection, amputations, and even death.
- Conditions
- Diabetes Mellitus, Diabetic Peripheral Neuropathy, Diabetic Foot Ulcer
- Trial name
- NCT05281562
- Testing
- Lovaza, L-Arginine Powder, Vitamin C
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Prisma Health-Midlands
Raynaud Disease, Systemic Sclerosis
Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study
This study evaluates the efficacy and safety of routine medical treatments of digital ulcers in patients with systemic sclerosis in a prospective cohort study.
- Conditions
- Raynaud Disease, Systemic Sclerosis, Digital Ulcer
- Trial name
- NCT02642146
- Testing
- Calcium Channel Blockers, Phosphodiesterase Inhibitors, Endothelin receptor blocker
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Seoul National University Hospital
Gastric Bypass
SH Dr. Chen Gastric Bypass Study
Evaluation of serum gastrin levels and their effect on marginal ulcer formation.
- Trial name
- NCT05357443
- Testing
- Gastric bypass with transection of vagal nerves, Gastric bypass without transection of vagal nerves
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Pressure Injury
Simulation Applications on the Level of Pressure Injury Knowledge and Evaluation
When the literature is examined, it is seen that the pressure injury knowledge and evaluation levels of nursing students are low.
- Trial name
- NCT05946291
- Testing
- Pressure injury training, Simulated Manneqquin training
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Ulcerative Colitis, Pediatric
Trial of a Decision Support Intervention for Adolescents and Young Adults With Ulcerative Colitis
A web application decision support tool has been developed for adolescents and young adults (AYAs). The purpose of this pilot trial is to test the web application for adolescent and young adults (AYAs) with Ulcerative Colitis…
- Trial name
- iBDecide (NCT04207008)
- Testing
- iBDecide Decision Support Application
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Ulcerative Colitis in Remission, Ultrasound
Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound
Rationale: Ulcerative colitis (UC) is remitting disease with a variable course. Predicting disease relapse after remission is important for the adjustment of medical treatment.
- Conditions
- Ulcerative Colitis in Remission, Ultrasound, Relapse/Recurrence
- Trial name
- PRELAPSE (NCT03501758)
- Testing
- Ultrasound, Analysis of prouroguanyline and uroguanyline in full blood
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Haukeland University Hospital
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