Clinical trials: Ulcerative Colitis Acute
Ulcerative Colitis Acute
Efficacy of Cyclosporine Rescue Therapy in Acute Ulcerative Colitis.
The efficacy and safety of Cyclosporine A as rescue therapy for acute severe ulcerative colitis in long-term follow-up.
- Trial name
- Cyclo (NCT05219656)
- Testing
- Cyclosporine A
- Volunteers
- 182 people
- Sponsor
- Tampere University Hospital
Ulcerative Colitis
Serum Lactate and Ulcerative Colitis
Patients presenting with severe symptoms of ulcerative colitis (UC) require hospital admission for urgent assessment and therapy.
- Trial name
- NCT05876494
- Testing
- serum lactate
- Where
- Egypt
- Volunteers
- 137 people
- Sponsor
- Assiut University
Ulcerative Colitis
Efficacy and Safety of Two Doses of SPD476 (Mesalazine) 2.4g and 4.8g Once Daily, With Reference to Asacol 0.8g Three Times Daily in Subjects With Acute, Mild to Moderate Ulcerative Colitis
The primary objective of the study was to compare the percentage of subjects in remission after 8 weeks of treatment with SPD476, 2.4 g/day once daily vs placebo and SPD476 4.8 g/day once daily versus placebo
- Trial name
- NCT00548574
- Testing
- SPD476 is a polymeric matrix formulation that displays both delayed- and extended-release of mesalazine, Mesalazine
- Where
- Belgium
- Volunteers
- 343 people
- Sponsor
- Shire
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Inflammatory Bowel Diseases, COVID
PROTECT-ASUC: Covid-19 Pandemic Response Of assessmenT, EndosCopy and Treatment in Acute Severe Ulcerative Colitis
Whether the perceived changes in management of Acute Severe Ulcerative Colitis during the COVID pandemic are widespread, and whether they have any impact on patient outcomes
- Trial name
- PROTECT-ASUC (NCT04411784)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Ulcerative Colitis
Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids
All episodes of patients with acute UC admitted to Tampere University Hospital and treated with intravenous corticosteroids between January 2007 and January 2016 were identified from patient records and reviewed.
- Trial name
- NCT04564638
- Testing
- Corticosteroid
- Volunteers
- 217 people
- Sponsor
- Tampere University Hospital
Ulcerative Colitis
A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
PHASE : IV TYPE OF STUDY : With direct benefit. DESCRIPTIVE : Multicentre, randomized, open label study. INCLUSION CRITERIA : Acute severe ulcerative colitis.
- Trial name
- ACTIVE (NCT02425852)
- Testing
- Azathioprine, Infliximab, Prednisolone
- Where
- 16 sites in France
- Volunteers
- 65 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis (UC), Acute Severe Ulcerative Colitis
Effectiveness and Safety of Upadacitinib for Acute Severe Ulcerative Colitis
The aim of this retrospective observational study is to investigate and compare the real-world effectiveness and safety of upadacitinib when used as first-line exposure versus rescue exposure in patients with acute severe…
- Conditions
- Ulcerative Colitis (UC), Acute Severe Ulcerative Colitis, Upadacitinib
- Trial name
- NCT07472309
- Testing
- Upadacitinib
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis, Inflammatory Bowel Diseases
Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis
The study is planned as a randomised control trial to study the adjuvant use of antibiotics (ceftriaxone and metronidazole) to achieve a clinical response in hospitalised patients with acute severe ulcerative colitis
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Acute Severe Colitis
- Trial name
- AAASUC (NCT03794765)
- Testing
- Ceftriaxone, Metronidazole
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ulcerative Colitis, Inflammatory Bowel Diseases
Russian Extremely Severe Ulcerative Colitis Study
The purpose of this study is prove the need to selection of a extremely severe ulcerative colitis, to identify predictors of colectomy, which will reduce the optimal time for surgery.
- Trial name
- REXs_UC (NCT03947931)
- Where
- Russia
- Volunteers
- 71 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Ulcerative Colitis Acute
Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcerative Colitis
The goal of this trial is to create personalized treatments for each patient admitted to the hospital with acute severe ulcerative colitis (ASUC).
- Trial name
- NCT05867329
- Testing
- Cyclosporine Injection (IV), Cyclosporine Oral Product, Upadacitinib Extended Release Oral Tablet
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Berinstein, Jeffrey
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Ulcerative Colitis
A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis
This is a multicenter, placebo-controlled, parallel-group, pilot study to evaluate safety and preliminary effectiveness of two blinded dose levels of telotristat etiprate (LX1606) in participants with acute, mild to moderate…
- Trial name
- NCT01456052
- Testing
- Telotristat Etiprate
- Where
- 24 sites in United States, Lithuania and 2 more
- Volunteers
- 59 people
- Sponsor
- Lexicon Pharmaceuticals
Ulcerative Colitis, Inflammatory Bowel Diseases
Janus Kinase Inhibitors for the Treatment of Acute Severe Ulcerative Colitis
Ulcerative colitis (UC) is an incurable, immune-mediated inflammatory disease of the large bowel that typically requires long term immunosuppressive drugs to induce and maintain remission.
- Trial name
- ATTRACT (NCT06449820)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Central Hospital, Nancy, France
Colitis, Ulcerative
TITRATE (inducTIon for acuTe ulceRATivE Colitis)
The aim of this study is to investigate whether intensive, personalized IFX dosing by using a pharmacokinetics driven dashboard system during the induction phase in patients with acute severe UC leads to increased treatment…
- Trial name
- TITRATE (NCT03937609)
- Testing
- Infliximab
- Where
- 7 sites in Ireland, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Ulcerative Colitis Acute, Surgery
Indicators Predicting Surgery in Acute Severe Ulcerative Colitis(ASUC)
Acute severe ulcerative colitis [ASUC] patients have high risk of no response to medical treatments and might miss the best timing for surgery when waiting for the medical response.
- Trial name
- NCT03578692
- Volunteers
- 146 people
- Sponsor
- Gao Tao
Ulcerative Colitis
Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe…
- Trial name
- MASCC (NCT03669822)
- Testing
- Standard of care
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Johns Hopkins University