Clinical trials: Ultra-low-dose CT
Head Injuries, Penetrating, Head Injuries, Closed
Concordance Between Ultra-low Dose (ULD) and Standard Dose CT Scans in the Search for Traumatic Brain Injury
The aim of this research is to evaluate the diagnostic concordance of ultra low-dose and standard dose reconstructed computed tomography acquisitions using the ADMIRE algorithm to search for intracranial lesions - both…
- Trial name
- ULD-CRANE (NCT04939688)
- Testing
- Conventional dose AND ultra low-dose CT scanning in the search for cranial lesions
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Urolithiasis, Urinary Tract Stones
Detection of Urinary Stones on ULDCT With Deep-learning Image Reconstruction Algorithm
Urolithiasis has an increasing incidence and prevalence worldwide, and some patients may have multiple recurrences. Because these stone-related episodes may lead to multiple diagnostic examinations requiring ionizing radiation…
- Conditions
- Urolithiasis, Urinary Tract Stones, Renal Colic, Deep Learning Reconstruction
- Trial name
- URO DLIR (NCT04490343)
- Testing
- Abdominopelvic low dose CT
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sarcoidosis, Pulmonary
SARCOLOWDOSE : Ultra-low Dose CT Scan and MRI in Thoracic Sarcoidosis
The goal of this study is to evaluate the diagnostic agreement between, on the one hand, ultra-low dose CT and MRI with UTE pulse sequences, and on the other hand, standard CT scan, to quantify lung parenchyma patterns in…
- Trial name
- SARCOLOWDOSE (NCT03140644)
- Testing
- Patients with thoracic sarcoidosis
- Where
- 7 sites in France
- Volunteers
- 196 people
- Sponsor
- Rennes University Hospital
Pulmonary Nodule, Multiple
Ultra-Low Dose CT Denoising for Lung Nodule Detection
We will perform an ultra low-dose CT (ULDCT) in addition to a regular chest CT scan for adult patients undergoing a clinically indicated chest CT.
- Trial name
- NCT03159377
- Testing
- Ultra low dose chest CT
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Sheba Medical Center
Hereditary Hemorrhagic Telangiectasia
Ultra-low-dose Chest CT for HHT
This study aims to develop a novel ultra-low dose chest CT technology for use in Hereditary Hemorrhagic Teleangiectasia (HHT) patients and to determine the lowest possible radiation dose that is achievable without sacrificing the…
- Trial name
- NCT04874558
- Testing
- Ultra-low dose chest CT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Pneumonia
Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR]
The ULTRACHEST study will be a prospective clinical diagnostic performance study with primary objective to establish device diagnostic clinical performance of Ultra Low Dose CT (ULD-CT) in order to prove it is more accurate in…
- Trial name
- ULTRACHEST (NCT03140163)
- Testing
- ULD-CT, CXR
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Wounds and Injuries, Hands, Wounds and Injuries, Wrists
ULD-E (Ultra Low Dose Extremities)
extremity trauma is a frequent reason for emergency room visits. There is an increase in the use of CT scanners in extremity trauma, due to a greater sensitivity of detection than X-rays, particularly for "occult fractures" and…
- Conditions
- Wounds and Injuries, Hands, Wounds and Injuries, Wrists, Wounds and Injuries, Feet, Wounds and Injuries, Ankles
- Trial name
- ULD E (NCT04832490)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared to…
- Conditions
- Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Stroke
- Trial name
- CRICKET (NCT02173470)
- Testing
- CT scan
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 866 people
- Sponsor
- UMC Utrecht
Radiation Exposure, Lung Embolism
Ultra Low Dose CT and Use of Iomeron 400 in PCD-CT
Evaluation of ultra low dose protocols and Iomeron 400 contrast in PCD-CT
- Conditions
- Radiation Exposure, Lung Embolism, Lung Cancer, Pneumonia
- Trial name
- NCT06360627
- Testing
- Computed Tomography
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Aortic Aneurysm, Thoracic, Aortic Aneurysm, Abdominal
Development of Ultra-Low Dose CT Based Screening for Aortic Aneurysms
The primary objective of this research project is development and validation of a new, non-contrast gated aortic (NCGA) computer tomography scan algorithm for screening of aortic aneurysm in the chest and abdomen in at risk…
- Trial name
- NCT03479164
- Testing
- Ultra Low-Dose CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Model-based Iterative Reconstruction (MB-IR VEOTM)
Model-based Iterative Reconstruction (MB-IR VEOTM) in Ultra Low-dose Abdominal CT Versus Adaptative Statistical Iterative Reconstruction (ASIR): A Prospective Study for Acute Renal Colic
The purpose of this study is to determine if Model-based iterative reconstruction (MB-IR VEOTM) in ultra low-dose abdominal CT as the same accuracy for the diagnosis of acute renal colic versus standard CT with adaptative…
- Trial name
- VEOLITH (NCT02076737)
- Testing
- Model-based iterative reconstruction (MB-IR VEOTM) on CT Discovery 750HD (GE Healthcare, Milwaukee, WI)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
PET/CT
Assessing Ultra-low Dose PET/CT and CT-less PET Using a Long Axial Field-of-view PET/CT System
Latest generation extended axial field-of-view (FOV) PET/CT systems offer the potential for substantial reductions in applied radiopharmaceutical necessary for a clinical scan.
- Trial name
- ULD-PET (NCT05496920)
- Testing
- FD-PET/CT, LD-PET/CT
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Non-Alcoholic Fatty Liver Disease, Steatosis of Liver
CT Liver Fat Fraction Quantification
Our aim is to develop an AI based tool to use ultra-low dose CT in two separate energy levels using a single-energy CT machine to quantify liver fat in individuals at risk for having non-alcoholic fatty liver disease (NAFLD)…
- Trial name
- NCT05676177
- Testing
- Ultra Low Dose CT, Fat quantification MRI
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Lung Diseases
Effectiveness of Ultra-low-dose Chest CT With AI Based Denoising Solution
The main objective of the study is to evaluate the detection rate of pulmonary conditions, percentage of ionizing radiation dose reduction, and state of image quality of ULDCT coupling with innovative vendor-neutral CT denoising…
- Trial name
- NCT05398887
- Testing
- Low radiation dose CT, Underwent ultra dose chest CT, Artificial Intelligence based model
- Volunteers
- 200 people
- Sponsor
- Intermed Hospital
Respiratory Tract Infections
The Value of Ultralow Dosis CT and Ultrasound in the Diagnosing of Pneumonia in the Emergency Department
Pneumonia is one of the most common infections in the emergency department (ED). Nevertheless, the current diagnostic tools are often slow and inaccurate.
- Trial name
- NCT04645030
- Testing
- Ultra low-dose computer thermography, lung ultrasound
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Coronary Artery Disease
Ultra Low Dose CT for CACS and AC of SPECT
The aim of the study is to compare the CACS obtained from standard dose CT to the CACS obtained from ultra-low-dose scans. Additionally, the usefulness of ultra-low-dose CT for AC of myocardial perfusion SPECT will be assessed.
- Trial name
- NCT02458352
- Testing
- Ultra low dose non-contrast enhanced CT, Standard dose non-contrast enhanced CT
- Where
- Switzerland
- Volunteers
- 105 people
- Sponsor
- University of Zurich
Pulmonary Nodules, Multiple
Detection and Volumetry of Pulmonary Nodules on Ultra-low Dose Chest CT Scan With Deeplearning Image Reconstruction Algorithm (DLIR)
evaluate the diagnostic performance of ultra-low dose CT using deep learning-based reconstruction in the detection of pulmonary nodules.
- Trial name
- DLIRTHORAX (NCT04482114)
- Testing
- ULD CT
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Closed Head Injury, Penetrating Head Injury
Comparison of Image Quality Between Ultra-low Dose (ULD) and Standard Dose CT Scans in Detecting Traumatic Brain Injury in the Emergency Room
Head trauma is a frequent reason for consultation in the emergency room. The CT scan is the reference examination allowing rapid management of the patient.
- Trial name
- ULD-CRANE 2 (NCT05210855)
- Testing
- CT scan
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Community Acquired Pneumonia (CAP)
Chest Radiography Versus Ultra-Low-Dose Chest Computed Tomography in Adults in the Emergency Department
Objective: To quantify and compare total staff person-time per imaging episode betweenconventional chest radiography (CXR) and ULDCT in adult emergency department patients in whom CAP is a differential diagnosis.
- Trial name
- TIME-CAP (NCT07870525)
- Testing
- ULDCT
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- University of Southern Denmark
Tuberculosis, Pulmonary, Latent Tuberculosis
Early Diagnosis of Active Tuberculosis Using Ultra Low-dose Chest CT
The aim of this study is to evaluate ultra low dose chest computed tomography (ULDCT) for early diagnosis of active tuberculosis in cohort of close contacts of active pulmonary tuberculosis for 1 year follow up
- Trial name
- NCT03220464
- Testing
- Ultra low dose chest computed tomography (ULDCT), Chest X-ray, Interferon-gamma Release Assay (IGRA)
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital