Clinical trials: Uncertainty
Breast Cancer, Breast Lesions of Uncertain Malignant Potential (B3 Lesions)
BRCA1, RASSF1A and PTEN Methylation in Breast Lesions of Uncertain Malignant Potential
This prospective interventional diagnostic study evaluates the clinical utility of methylation analysis of BRCA1, RASSF1A and PTEN genes in breast lesions of uncertain malignant potential (B3 lesions).
- Trial name
- NCT07416500
- Testing
- MS-MLPA Methylation Analysis
- Where
- Slovenia
- Volunteers
- 301 people
- Sponsor
- Institute of Oncology Ljubljana
Undiagnosed Disease
Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing
Background: People with conditions that are unknown or hard to diagnose may be helped by a genetic technique. It is called exome sequencing. It helps diagnose disease by unlocking all the data in a person s genetic code.
- Trial name
- NCT03605004
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Prostate Cancer
Large Language Model-Assisted cTNM Annotation From Chinese PSMA PET/CT Reports
This observational study will develop and validate a large language model-assisted workflow for imaging cTNM staging annotation and uncertainty recognition in prostate cancer using Chinese PSMA PET/CT report texts generated…
- Trial name
- PSMA-LLM-cTNM (NCT07707232)
- Testing
- Large Language Model-Assisted Report Annotation
- Where
- China
- Volunteers
- 4,600 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Atypical Squamous Cell of Undetermined Significance, ASC-US
Comparison Of Cytology And Molecular Screening For Detecting Cervical Reactive Cellular Changes In General Population
This study compares the efficacy of cytology (Pap smear) with the molecular screening in their ability to detect reactive cellular changes in the cervix among an open population
- Conditions
- Atypical Squamous Cell of Undetermined Significance, ASC-US, Atypical Glandular Cells of Uncertain Significance, AGUS
- Trial name
- NCT07211204
- Testing
- Physical examination, Liquid-based cytology, Molecular screening
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Timser SAPI de CV
Pigmented Skin Lesion of Uncertain Nature
Skin Imaging With Technologies in Development
The purpose of this research is to develop non-invasive imaging modalities for assessment of skin. This is a pilot study which will use multiple imaging modalities to collect information on normal and lesional skin.
- Trial name
- NCT00764920
- Testing
- non-invasive imaging modalities for assessment of skin
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Parkinson's Disease, Dystonia
Perceptual Decision Making Under Conditions of Visual Uncertainty
In this proposal the investigators have three Specific Aims using human patient populations as model systems; 1) identify a role for the Basal Ganglia (BG) in perceptual decision making; 2) determine whether the Basal Ganglia…
- Conditions
- Parkinson's Disease, Dystonia, Ataxia
- Trial name
- NCT01845883
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Generalized Anxiety Disorder
Testing Beliefs About Uncertainty in the Treatment of Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) is an anxiety disorder characterized by excessive and uncontrollable worry. Our research group has developed a cognitive-behavioural treatment (CBT) for GAD centered upon intolerance of…
- Trial name
- NCT01958788
- Testing
- Cognitive-Behavioural Treatment
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Concordia University, Montreal
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Healthy Subjects
Cognitive Biases Under Ketamine
Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis. Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is…
- Trial name
- KETABI (NCT02235012)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
ER-positive Her2-negative Early Breast Cancer
Assessment of Genomic Test Impact on Shared Decision of Adjuvant Chemotherapy in ER-positive, Her2-negative Early Breast Cancer
The need/benefit of adjuvant chemotherapy could be negligible for a certain category of patient with newly diagnosed unilateral non metastatic breast cancer.
- Trial name
- OPTIGEN (NCT03080428)
- Testing
- Genomic test
- Sponsor
- UNICANCER
Patients With Uncertain Difficult Airway, Colon Cancer
Safety and Feasibility of Reversible Induction Strategy
This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term…
- Conditions
- Patients With Uncertain Difficult Airway, Colon Cancer, Gastric Cancer, Prostatic Cancer
- Trial name
- NCT04434963
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Peritoneal Carcinosis
Safety of Intraperitoneal (IP) OXAliplatin (OXA) in Association With Systemic FOLFIRI Bevacizumab Chemotherapy in Patients With Peritoneal Carcinosis
Peritoneal carcinosis (PC) corresponds to a locoregional extension into the peritoneum of rare primary peritoneal cancers, or more frequently distant extension of digestive cancers (colorectal or gastric) or gynecological…
- Trial name
- IPOXA (NCT02866903)
- Testing
- intraperitoneal (IP) OXAliplatin (OXA) + systemic FOLFIRI bevacizumab chemotherapy
- Where
- 6 sites in France
- Volunteers
- 47 people
- Sponsor
- Hospices Civils de Lyon
Preoperative Anxiety, Perceived Control
Structured Communication About Artificial Intelligence in Perioperative Care (AI-COM)
This study investigates whether structured communication about artificial intelligence (AI) in perioperative care can reduce preoperative anxiety and improve perceived control among adult patients undergoing elective surgery.
- Conditions
- Preoperative Anxiety, Perceived Control, AI-Related Uncertainty
- Trial name
- AI-COM (NCT07393945)
- Testing
- Structured Artificial Intelligence Communication, Attention-Control Supportive Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Agri Ibrahim Cecen University
Obsessive-Compulsive Disorder
Decision-making Impairments in OCD: An Integrated Behavioral Economics Model
The investigators are examining whether conditions of ambiguity during decision-making may prime intolerance of uncertainty beliefs (i.e., difficulties coping with ambiguity, unpredictability, and the future) and lead to impaired…
- Trial name
- NCT03420495
- Testing
- Decision-Making Tasks
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Intolerance of Uncertainty, Anxiety
Test of Target Engagement of Ambiguity Aversion
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
- Conditions
- Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
- Trial name
- NCT06962527
- Testing
- Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Uncertainty, Advanced Cancer
Uncertainty in Illness in Palliative Care: an Intervention for Family Caregivers
Background: The increase of chronic diseases has reached an increase in the suffering of advanced diseases and an inability of health care systems to give access to the population that suffers them.
- Conditions
- Uncertainty, Advanced Cancer, Family Members, Quality of Life
- Trial name
- NCT03518970
- Testing
- Nursing intervention
- Volunteers
- 60 people
- Sponsor
- Universidad Nacional de Colombia
BRCA1 Mutation, POLD1 Gene Mutation
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
The purpose of this study is to examine the impact of new cancer genetic counseling models that aim to increase patient engagement with the genetics team.
- Conditions
- BRCA1 Mutation, POLD1 Gene Mutation, CDKN2A Mutation, BRCA2 Mutation
- Trial name
- NCT05420064
- Testing
- Intervention Arm At-risk Relative/ARR Contacts, MyGene Portal, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cognition of Osteopath
Measurement of the Intolerance to Uncertainty in Osteopaths
Clinical reasoning is a challenging, complex, multi-dimensional, essentially introspective and poorly understood cognitive process, as well as a crucial skill for osteopaths and health professionals.
- Trial name
- NCT06695806
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Institut des Hautes Etudes Osteopathiques de Nantes
Cardiovascular Diseases, Heart Diseases
Physician Uncertainty Reduction for Hypertension
The purpose of this study is to test the theory that a major factor in poor blood pressure (BP) control is that physicians fail to intensify antihypertensive therapy for their patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00201084
- Testing
- Uncertainty reduction
- Where
- United States
- Volunteers
- 670 people
- Sponsor
- Baylor College of Medicine
Infections
Validation of Betalactam ML Prediction Models - TDMAide
The goal of this study is to learn about the real wold behavior of developed machine learning models that predict the plasma concentration of piperacillin-tazobactam and meropenem in critically ill patients admitted to the…
- Trial name
- TDMAide (NCT06026852)
- Testing
- Prediction of plasma concentration of piperacillin-tazobactam or meropenem, Determination of plasma concentration of piperacillin-tazobactam or meropenem, Daily short questionnaire
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent