Clinical trials: Uncomplicated Pregnancy
Recurrent Urinary Tract Infection
Nutritional Supplementation for Recurrent Urinary Tract Infections in Women
The study will test the ability of specially formulated nutritional supplement capsules to extend the time between recurrent urinary tract infections in women.
- Trial name
- NCT03597152
- Testing
- WelTract
- Volunteers
- 250 people
- Sponsor
- AmPurity Nutraceuticals, LLC
Obstetric Labour, Premature
The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor
Pre-Term Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00404768
- Testing
- GSK221149A
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 93 people
- Sponsor
- GlaxoSmithKline
Plasmodium Vivax Malaria
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV)
The current treatment recommendations for P. vivax in pregnant and non-pregnant individuals are to use chloroquine; in non-pregnant patients this is followed by primaquine to prevent relapse.
- Trial name
- PAACT-PV (NCT01107145)
- Testing
- Mefloquine- Artesunate, Artemether-Lumefantrine, Chloroquine
- Where
- 3 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- Centers for Disease Control and Prevention
Urinary Tract Infections
A Study of Efficacy and Safety of Intravenous Cefiderocol (S-649266) Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections
The purpose of this study was to determine the efficacy and safety of intravenous cefiderocol (S-649266) in hospitalized adults with complicated urinary tract infections caused by Gram-negative pathogens.
- Trial name
- APEKS-cUTI (NCT02321800)
- Testing
- Cefiderocol, Imipenem/cilastatin
- Volunteers
- 452 people
- Sponsor
- Shionogi
Labor Complication
Traditional WHO Partograph and Korle-Bu Modified WHO Partograph for Uncomplicated Labour
Brief Background: The partograph is a graphical representation of the events in the first stage of labour. It is an instrument used in monitoring the well being of both the pregnant woman and her fetus (es) as they go through the…
- Trial name
- NCT05837559
- Testing
- Korle-Bu Modified WHO Partograph for Uncomplicated Labour
- Where
- Ghana
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ghana Medical School
Urinary Tract Infections
Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial
It is well known that "over-treatment" of straightforward infections should be avoided as far as possible. Evidence-based data on non antibiotic treatment options for common conditions are therefore needed urgently.
- Trial name
- REGATTA (NCT03151603)
- Testing
- Arctuvan, Fosfomycin
- Where
- 47 sites in Germany
- Volunteers
- 398 people
- Sponsor
- University Medical Center Goettingen
Urinary Tract Infection
Efficacy of CLR Compared to Fosfomycin Trometamol in Acute Lower uUTIs
To demonstrate non-inferiority of a non-antibiotic therapy with CLR versus an antibiotic treatment with fosfomycin trometamol in women suffering from acute lower uUTIs as measured by the proportion of patients who received an…
- Trial name
- NCT02639520
- Testing
- Canephron® N, Fosfomycin trometamol
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Bionorica SE
Urinary Tract Infections
Phase II Proof of Concept Study in Uncomplicated UTI
A study of the efficacy and safety of MPC-SHRC for the relief of symptoms associated with uncomplicated urinary tract infections.
- Trial name
- NCT03129295
- Testing
- MPC-SHRC
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mission Pharmacal
Urinary Tract Infections
A Study in Adolescent and Adult Female Participants to Evaluate Clinical Symptom Improvement and the Safety of Gepotidacin During Treatment of Uncomplicated Urinary Tract Infections (Acute Cystitis)
The study will be conducted to evaluate the clinical symptom improvement and safety of oral gepotidacin for treatment of uncomplicated UTI (acute cystitis) in adolescent and adult female participants.
- Trial name
- SIS (NCT06597344)
- Testing
- Gepotidacin
- Where
- 22 sites in United States
- Volunteers
- 97 people
- Sponsor
- GlaxoSmithKline
Malaria, Pregnancy, Malaria, Antepartum
Safety of Antimalarials in the FIRst trimEster
The SAFIRE study aims to find effective treatments with acceptable safety for malaria in early pregnancy, a particularly sensitive time for the adverse consequences of malaria in pregnancy for both mother and baby.
- Conditions
- Malaria, Pregnancy, Malaria, Antepartum, Malaria (Uncomplicated)
- Trial name
- SAFIRE (NCT06962319)
- Testing
- dihydroartemisinin-piperaquine (DP), Pyronaridine-artesunate (PA), Artemether-lumefantrine
- Where
- 3 sites in Burkina Faso, Kenya and 1 more
- Volunteers
- 1,510 people
- Sponsor
- Liverpool School of Tropical Medicine
Sleep Initiation and Maintenance Disorders, Sleep
Sleep Disturbances in the 2nd and 3rd Trimester
Sleep disorders and disturbances are mostly underestimated in clinical practice. Moreover, this problem is generally neglected by the pregnant themselves.
- Conditions
- Sleep Initiation and Maintenance Disorders, Sleep, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03763071
- Testing
- Patient-reported scales to measure sleep disorders
- Where
- Turkey (Türkiye)
- Volunteers
- 683 people, healthy volunteers welcome
- Sponsor
- Bartin State Hospital
Urinary Tract Infections
A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI)
The study will be conducted to evaluate the therapeutic response (combined per participant microbiological and clinical response) of oral gepotidacin compared to oral nitrofurantoin for treatment of uncomplicated UTI (acute…
- Trial name
- NCT04020341
- Testing
- Gepotidacin, Nitrofurantoin
- Where
- 103 sites in United States, Bulgaria and 10 more
- Volunteers
- 1,531 people
- Sponsor
- GlaxoSmithKline
Uncomplicated Urinary Tract Infections, Urinary Tract Infections
Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract Infections
This phase 1b study is a double-blind, double-dummy, nitrofurantoin-controlled study designed to evaluate microbiological response at the test of cure (ToC) visit along with safety, tolerability and pharmacokinetic (PK) response…
- Trial name
- NCT05138822
- Testing
- GSK3882347, Nitrofurantoin
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- GlaxoSmithKline
Gestational Diabetes Mellitus (GDM), Postpartum Women
The Impact of Gestational Diabetes Mellitus on Cerebral Blood Flow and Cerebrovascular Function After Pregnancy
Gestational Diabetes Mellitus (GDM) currently affects approximately 14% of all pregnancies worldwide. Importantly, the health-related consequences of GDM extend well beyond pregnancy, such that women with a history of GDM have a…
- Conditions
- Gestational Diabetes Mellitus (GDM), Postpartum Women, Uncomplicated Pregnancy
- Trial name
- NCT06911372
- Testing
- Intradermal Microdialysis, Brain Blood Flow Tests, Local Heating
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Antiphospholipid Syndrome in Pregnancy, Anticoagulants
HYDROxychloroquine in Syndrome Primary AntiPhospholipid
Antiphospholipid syndrome (APS) is defined by thrombosis or obstetric complication (≥ 3 spontaneous miscarriages or fetal death or prematurity <34 weeks gestation-related amenorrhea (SA)) associated with antiphospholipid…
- Trial name
- HYDROSAPL (NCT04275778)
- Testing
- Plaquenil 200Mg Tablet
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pelvic Inflammatory Disease
Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin.
Comparison of various antibiotics in treatment of uncomplicated pelvic inflammatory disease
- Trial name
- MAIDEN (NCT00683865)
- Testing
- Ofloxacin, Avelox (Moxifloxacin, BAY12-8039)
- Where
- 77 sites in Denmark, Finland and 11 more
- Volunteers
- 749 people
- Sponsor
- Bayer
Urinary Tract Infections
Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting
The purpose of this research study is to determine if gentamicin is as effective treatment of acute uncomplicated cystitis (urinary tract infection) using aminoglycosides versus the current standards of care.
- Trial name
- NCT05702762
- Testing
- Gentamicin, Standard of Care
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mercy Health Ohio
Pregnancy, Prelabor Rupture of Membranes
Safety Study of Membrane Sweeping in Pregnancy
The purpose of this study is to determine if routine membrane sweeping in uncomplicated term pregnancies increases the rate of pre-labor rupture of membranes.
- Trial name
- NCT00294242
- Testing
- Membrane Sweep, No Membrane Sweep
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tripler Army Medical Center
Acute Renal Colic, Nephrolithiasis
Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic
Prospective single centre study aiming at validating a conditional imaging strategy for diagnosis of suspected kidney stone. Consecutive Emergency department patients referred to the medical imaging department for exploration of…
- Trial name
- IMAGENCO (NCT02878148)
- Testing
- Diagnostic imaging modalities for suspected renal colic
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Montpellier
Urinary Tract Infections
Improving Care for Uncomplicated URinary Tract Infection-associated Symptoms in Primary Healthcare Settings in INDOnesia
In the present study, we aim to analyze the impact of the introduction of a urinary dipstick test for patients presenting with uncomplicated UTI-associated symptoms on antibiotic prescription in primary health care in Indonesia.
- Trial name
- URINDO (NCT06307067)
- Testing
- Urine dipstick
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Erasmus Medical Center