Clinical trials: Unconscious
Cardiovascular Diseases, Arrhythmia
Identifying High Risk Patients With Syncope
To validate two models which categorized patients with syncope into high and low risk for either sudden death or diagnostic arrhythmias based on data available from the initial history, physical examination, and electrocardiogram.
- Conditions
- Cardiovascular Diseases, Arrhythmia, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00005202
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Traumatic Brain Injury, Cerebral Anoxia
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
Within the framework of a prospective double-blind and randomized study evaluating the efficacy of continuous intrathecal baclofen therapy (CIBT) on paroxysmal dysautonomia (main objective) and hypertonia, recovery and tolerance…
- Conditions
- Traumatic Brain Injury, Cerebral Anoxia, Coma, Hypertonia
- Trial name
- NCT00221689
- Testing
- baclofen (drug)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Age-Related Macular Degeneration, Cataract
The Effect of Ranibizumab on Eye Lens Opacity in Cases With Age-Related Macular Degeneration
Purpose To evaluate the cataractogenic effect of intravitreal ranibizumab with the use of Lens Opacity Classification System III (LOCS III).
- Trial name
- NCT01330797
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Uludag University
Type1diabetes
IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase
The purpose of this study is to determine how Humulin-R regular insulin affects the body's ability to feel low blood sugar (hypoglycemia) when delivered intranasally compared to placebo in subjects with Type 1 Diabetes (T1D) with…
- Trial name
- NCT04028960
- Testing
- Regular insulin (Humulin-R), intranasal route, SipNose intranasal device
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Brain Death, Organ Donation
Donation Network to Optimize Organ Recovery Study
This study consists in an cluster-randomized clinical trial involving near 60 Brazilian intensive care units (ICUs) with a high notification rate of potential donors of organs and tissues.
- Trial name
- DONORS (NCT03179020)
- Testing
- Checklist use, Usual care
- Where
- 63 sites in Brazil
- Volunteers
- 1,535 people
- Sponsor
- Hospital Moinhos de Vento
Syncope, Vasovagal, Neurally-Mediated
Mechanism-based Therapy of Hypotensive Syncope
The aim of this study is to assess the efficacy of a therapeutic strategy aimed to increase 24-hour systolic blood pressure (SBP) values, assessed by 24-hour ambulatory blood pressure monitoring (ABPM), in reducing syncope…
- Trial name
- 2STEPtherapy (NCT06513650)
- Where
- 9 sites in France, Italy and 3 more
- Volunteers
- 140 people
- Sponsor
- Istituto Auxologico Italiano
Coma, Heart Arrest
Predictive Outcome in Comatose Patients
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers…
- Conditions
- Coma, Heart Arrest, Cardiopulmonary Resuscitation
- Trial name
- PRECOM (NCT05321459)
- Testing
- Neurological prognosis
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Comatose
A Study of Transcutaneous Electrical Stimulation As a Noxious Stimulus for the Glasgow Coma Scale
The purpose of this study is to determine whether electrical stimulation can be used to replace physical stimulation to test awareness of patients with impaired consciousness.
- Trial name
- GCS02 (NCT06681779)
- Testing
- Transcutaneous electrical stimulation, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Markey Olson
Syncope, Vasovagal, Neurally-Mediated
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin.
- Trial name
- NCT06697145
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Wroclaw Medical University
Syncope, Presyncope
Sternal ECG Patch Comparison Trial
This study is intended to compare the new Carnation Ambulatory Monitoring (CAM) System, a patch monitoring system, with the Holter monitoring system.
- Conditions
- Syncope, Presyncope, Palpitations, Atrial Fibrillation
- Trial name
- NCT02126631
- Where
- New Zealand
- Volunteers
- 50 people
- Sponsor
- Bardy Diagnostics, Inc.
Stress, Psychological, Maternal Health
Caring for Providers to Improve Patient Experience (CPIPE) Trial
The activities described in this proposal are aimed at addressing health care provider stress and unconscious bias to improve quality of maternal health care, particularly related to the person-centered dimensions of care-i.e.
- Conditions
- Stress, Psychological, Maternal Health, Healthcare Provider, Adverse Outcomes
- Trial name
- CPIPE (NCT06085105)
- Testing
- CPIPE Training, Peer support groups, Mentorship
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 6,379 people
- Sponsor
- University of California, San Francisco
Cardiac Arrest, Out-Of-Hospital, Angiography
Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.
In patients with Out-of-Hospital Cardiac arrest who achieves Return Of Spontaneous Circulation (ROSC) The investigators want to evaluate whether there is a benefit from acute Angiography compared to subacute (12-24 hours)…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Angiography, Percutaneous Coronary Intervention, Coma
- Trial name
- DISCO-noCOMA (NCT04876222)
- Testing
- Acute CAG
- Where
- 7 sites in Denmark, Netherlands
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital Skejby
Acute and Chronic Hepatic Failure With Developing Coma
Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development…
- Trial name
- NCT01582087
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiac Pacing in Adherence With ESC Cardiac Pacing Guidelines
AVEIR™ Leadless Pacemaker Registry in Europe and MIddle East Region (PREMIER LEADLESS)
The AVEIR™ Leadless Pacemaker Registry (herein referred to as "PREMIER LEADLESS Registry") is a prospective, multicenter, International, open label observational study designed to evaluate safety and electrical performances of…
- Trial name
- NCT06782152
- Volunteers
- 1,698 people
- Sponsor
- King Fahad Armed Forces Hospital
TBI (Traumatic Brain Injury)
Asia Coma Electrical Stimulation (the ACES Trial)
This study is a prospective multicenter randomized controlled trial from Asian countries to compare the effect and safety of right median nerve stimulation versus traditional treatment for comatose patients at the early stage…
- Trial name
- ACES (NCT02645578)
- Testing
- Right median nerve stimulation
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Syncope, Vasovagal
Different Catheter Ablation Strategy in Vasovagal Syncope
This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1.
- Trial name
- NCT05573178
- Testing
- cardiac ganglion plexus ablation(cardioneuroablation)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- China National Center for Cardiovascular Diseases
Racism, Healthcare Disparities
Assessing Patient-provider Interactions During the Preoperative Anesthesia Consult
This will be a prospective, observational, single-center study to evaluate the effect of race and ethnicity on anesthesia provider-patient interactions.
- Conditions
- Racism, Healthcare Disparities, Minority Health
- Trial name
- IMPLICIT (NCT04508543)
- Testing
- Non-verbal communication score
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Oregon Health and Science University
Syncope, Presyncope
Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial
This study is intended to compare the new Carnation patch monitoring system with the Zio patch, which represents the current standard for continuous recording of the ECG over extended periods.
- Conditions
- Syncope, Presyncope, Palpitations, Atrial Fibrillation
- Trial name
- NCT02031484
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bardy Diagnostics, Inc.
Accidental Falls, Aged
Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall
Falls are one of the most common reasons older adults visit the emergency department. In many older patients, a fall that looks "mechanical" is actually caused by an underlying medical problem such as syncope, heart disease…
- Conditions
- Accidental Falls, Aged, Syncope
- Trial name
- NCT07886164
- Testing
- Whole-body point-of-care ultrasound (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kocaeli City Hospital
Disorders of Consciousness, Vegetative State
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness
Disorders of consciousness (DoC) are severe neurological conditions characterized by impaired awareness and reduced interaction with the environment.
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- AI-HBOT-DoC (NCT07855848)
- Testing
- AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.