Clinical trials: Unconscious
Irreversible Loss of Brain Function (ILBF)
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death).
- Trial name
- DETECT-IVE (NCT06293170)
- Testing
- DETECT, Conventional care
- Where
- Germany
- Volunteers
- 4,800 people
- Sponsor
- Technische Universität Dresden
Epilepsy, Cryptogenic Epilepsy
S100B Protein: a Diagnostic Aid in Episodes of Transient Loss of Consciousness?
S100B protein is a biomarker produced mainly by astrocytes and released into the bloodstream in the event of brain injury, with levels rising rapidly and markedly in acute conditions such as traumatic brain injury, stroke, or…
- Trial name
- EPILEPSY (NCT07527754)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia Brain Monitor, Anesthesia
Elucidating the Neural Correlates of Anesthesia-induced Unconsciousness in Neonates
This study will try to elucidate the neural responses of neonatal patients to surgery-level propofol infusions during induction and maintenance of anesthesia.
- Conditions
- Anesthesia Brain Monitor, Anesthesia, Neonatal Surgery
- Trial name
- NeoNCC (NCT07601854)
- Volunteers
- 64 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Consciousness Disorder, Minimally Conscious State
Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders of consciousness. Notably, a case reported improvement of level of consciousness using transcutaneous auricular vagal…
- Conditions
- Consciousness Disorder, Minimally Conscious State, Vegetative State
- Trial name
- NCT04065386
- Testing
- Active taVNS
- Where
- 2 sites in Belgium
- Volunteers
- 44 people
- Sponsor
- University of Liege
Syncope
Eastbourne Syncope Assessment Study II
Syncope (commonly called collapses or blackouts) is defined as loss of consciousness which is transient, self limiting and usually leads to falling.
- Trial name
- EaSyAS II (NCT00517023)
- Testing
- Sleuth Implantable Loop Recorder, Other
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- East Sussex Healthcare NHS Trust
Drug Resistant Epilepsy, Drop Seizures
Novel Helmet Design in Patients With Seizures
This is a two-part study that aims to determine the reliability and safety of the use of the Hövding inflatable helmet in seizures, as evidenced by the deployment of the helmet during seizures, and qualitative patient reporting.
- Conditions
- Drug Resistant Epilepsy, Drop Seizures, Generalized Tonic Clonic Seizure, Complex Partial Seizure
- Trial name
- NCT03443388
- Testing
- Hövding inflatable helmet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Michael A. Gelfand, MD, PhD
Brain Injuries
Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury
Appraised the empirical evidence of effectiveness of sensory stimulation to improve arousal and alertness for persons in a coma or persistent vegetative state after traumatic brain injury (TBI).
- Trial name
- NCT02629588
- Testing
- Multimodal or Unimodal Sensory stimulation
- Volunteers
- 9 people
- Sponsor
- Creighton University
Type 1 Diabetes, Healthy
Cerebral Responses to Insulin Induced Hypoglycemia
This research study is designed to investigate the effect of hypoglycemia (low blood sugar) on blood flow to and biochemistry in the brain.
- Conditions
- Type 1 Diabetes, Healthy, Hypoglycemia Unawareness
- Trial name
- 1018 (NCT02747680)
- Testing
- hypoglycemia (low blood sugar) in MRI
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypoglycemia, Reactive, Hypoglycaemia Night
CGM (Continuous Glucose Monitoring) Use in Diagnosis of Spontaneous and Reactive Hypoglycaemia
Use of CGM to determine diagnosis in possible spontaneous or reactive hypoglycaemia. Use of CGM to aid treatment optimisation in spontaneous or reactive hypoglycaemia
- Conditions
- Hypoglycemia, Reactive, Hypoglycaemia Night, Hypoglycemia Non-Diabetic, Hypoglycemia Unawareness
- Trial name
- NCT04452396
- Testing
- use of continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Barts & The London NHS Trust
Syncope, Loop Recorder
Syncope and Implanted Loop Recorder: the Utility of Remote Monitoring and Patients Centered Setting Alarms
Actually, there are few data about the effectiveness of remote monitoring (RM) and patient centered alarms setting in patients with unexplained syncope underwent implanted loop recorder (ILR) monitoring.
- Conditions
- Syncope, Loop Recorder, Remote Monitoring
- Trial name
- NCT04435262
- Testing
- Remote Monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Brain Death, Electroencephalogram
Research on the Brain Death Determination in China
Purpose China has a population of 1.4 billion and an enormous medical expenditure burden, and Chinese traditional culture has a long history. It takes time to recognize and accept the concept of brain death (BD) as death.
- Conditions
- Brain Death, Electroencephalogram, Evoked Potential, TCD
- Trial name
- RBDDC (NCT05903443)
- Testing
- ancillary tests
- Where
- China
- Volunteers
- 1,974 people
- Sponsor
- Xuanwu Hospital, Beijing
Brain Death, Lung Transplantation
Organ Donation Survey Among Health Care Professionals in Argentina
The aim of this study is to gather information about knowledge, professional experience and attitude toward organ donation among health care professionals involved in the care of potential donors about the procurement process and…
- Conditions
- Brain Death, Lung Transplantation, Respiration, Artificial, Tissue and Organ Procurement
- Trial name
- NCT03458052
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Hospital Italiano de Buenos Aires
Vasovagal Syncope
Syncope Prediction Study
The purpose of this study is to perform a prospective evaluation of the vasovagal syncope prediction algorithm, called Tilt Test Analyzer, during head up tilt testing tests in one center in the United Kingdom.
- Trial name
- SPS (NCT02140567)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Medtronic BRC
Arrythmia, Syncope
Arrhythmia Identification in Syncope Patients: ePatch® Versus 24h Holter
This study is a Multi-center, prospective, randomized, unblinded, two-arm study to assess if 7-days of cardiac monitoring using the ePatch Holter results in identification of more clinically actionable arrythmia for patients with…
- Trial name
- NCT06310707
- Testing
- ePatch ® Extended Wear Holter (EWH)
- Where
- 2 sites in France, Germany
- Volunteers
- 55 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Conditions of Brain
Electrophysiological Tests on Unconscious Patient
Most patients with minimal consciousness status in Critical Care Units (CCU) are considered as an 'unconscious patient' with a neurological examination.
- Trial name
- NCT03858400
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Nevsehir Public Hospital
Aortic Dissection, Stroke
Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection
Single-center retrospective cohort at China Medical University Hospital (Taichung, Taiwan) using fully de-identified electronic health records.
- Conditions
- Aortic Dissection, Stroke, Paraplegia, AKI - Acute Kidney Injury
- Trial name
- ATAAD-ICU (NCT07167628)
- Where
- Taiwan
- Volunteers
- 274 people
- Sponsor
- China Medical University Hospital
Lung Collapse
The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
- Trial name
- N-LAT-EIT (NCT04235231)
- Testing
- Bed tilting, Body positioning
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Regional Hospital Liberec
Minimally Conscious State, Vegetative State
Validation of the Chinese Version of the SECONDs
The aim of this study was to translate the SECONDs from English into Chinese and determine the validity of this Chinese version
- Trial name
- NCT04687553
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hangzhou Normal University
Locked- in Syndrome
A Method for Communication With Arabic Patients Suffering From Classic Locked- in Syndrome
Aim of the work The aim of this study is to test an Arabic alphabet communication system designed to train physicians to communicate with Arabic-speaking patients with LIS.
- Trial name
- NCT05444075
- Testing
- a method for communication
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University