Clinical trials: Uncontrolled Hypertension
Uncontrolled Hypertension, Treatment Compliance
Integrative Nursing Based Multimodal Interventions for Uncontrolled Hypertensives
Purpose: The aim of this study is to evaluate the effect of multimodal interventions based on Integrative Nursing (IN) principles on blood pressure, stress, and hypertensive treatment compliance levels in individuals living in…
- Conditions
- Uncontrolled Hypertension, Treatment Compliance, Behavior, Health, Nurse's Role
- Trial name
- UHTINuM (NCT04809519)
- Testing
- Integrative Nursing based Multimodal Interventions for Uncontrolled Hypertensives, Ongoing treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Hypertension, Cost Effectiveness
Cost-effectiveness of RAMP-HT for Patients With Uncontrolled Hypertension in Hong Kong
Hypertension (HT) is an important risk factor for stroke, coronary heart disease (CHD), heart failure and renal diseases, and the leading risk factor of global disease burden.
- Trial name
- NCT03301194
- Testing
- RAMP-HT
- Where
- Hong Kong
- Volunteers
- 158,322 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Uncontrolled Hypertension
SAL0140 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population
The purpose of this study is to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of SAL0140 healthy Chinese population.
- Trial name
- NCT07051603
- Testing
- SAL0140
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Hypertension
The Role of Gut Microbiota in Hypertension
Hypertension is the single most prevalent risk factor for heart diseases, heart failure, kidney failure and stroke. About 1 in 3 adults in the United States have hypertension.
- Trial name
- NCT02188381
- Testing
- Stool Sample and Blood Sample
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Florida
Uncontrolled Hypertension
Uncontrolled Hypertension Management (TEAM-HTN)
Current guideline directed medical therapies (GDMT) for hypertension (HTN) endorse a trial and error approach based on drug class.
- Trial name
- TEAM-HTN (NCT03281772)
- Testing
- Clinical Decision Software - provider portal, Clinical Decision Software - patient portal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Cardiovascular Disease
Evaluation of Patients With Heart Disease Not Eligible for Research Protocols
An important mission of the National Institutes of Health (NIH) is to develop and carry out research studies designed to improve understanding of disease processes and treatments.
- Trial name
- NCT00001458
- Where
- United States
- Volunteers
- 7,829 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Approaches to Reduce Clinical Inertia in Hypertension in the Dominican Republic
The purpose of this cluster randomized control trial is to test whether a multimodality strategy that includes an educational on-line course and performance feedback reports is effective to reduce clinical inertia in the…
- Trial name
- ARCH DR (NCT03954951)
- Testing
- Multimodality behavioral strategy
- Where
- Dominican Republic
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Hypertension
Telemonitoring of Uncontrolled Hypertension
The proportion of hypertensive patients achieving adequate blood pressure control meeting guideline targets remains low. Of those patients on blood pressure lowering drugs, only 50% reach control. Objectives: 1.
- Trial name
- ERNESTINA (NCT02730052)
- Testing
- Omron 9200T plus Telemonitoring, Omron 9200T without Telemonitoring
- Where
- 8 sites in Argentina, Uruguay
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad de la Republica
Uncontrolled Hypertension, BMI
PTSC: Improving Hypertension Control Among Poor Midlife African American Women
African American women are more likely to suffer higher rates of uncontrolled hypertension than non-Hispanic white women. Prime Time Sister Circles® (PTSC) empowers women to proactively manage their blood pressure by promoting…
- Conditions
- Uncontrolled Hypertension, BMI, Stress, Medication Adherence
- Trial name
- PTSC-RCT (NCT04371614)
- Testing
- Prime Time Sister Circle
- Where
- United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hypertension
Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The researchers hypothesize that: 1.
- Trial name
- Renin (NCT00684489)
- Testing
- clinical hypertension specialist-no specific med. Any anti-hypertension meds., renin guided therapeutics-no specific med. Any anti-hypertensive med.
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Uncontrolled Hypertension
A Food Effect Study of QLS1410 in Healthy Chinese Adults
This study is aimed to evaluate the effect of food on pharmacokinetics of QLS1410 in healthy Chinese adults.
- Trial name
- NCT07358858
- Testing
- QLS1410
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation in Uncontrolled Glaucoma
The goal of this study is to evaluate the efficacy and safety of the novel form of trans-scleral cyclophotocoagulation using micropulse diode laser and trans-pars plana treatment (Micropulse TSCPC, mTSCPC MP3, IRIDEX CYCLO G6™…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Neovascular, Glaucoma and Ocular Hypertension
- Trial name
- NCT03187418
- Testing
- MicroPulse® P3 Glaucoma Device (MP3)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hypertension
Effectiveness of a Valsartan Based Versus an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current Monotherapy
The population for this current study will include stage 1 and stage 2 hypertensive patients who are newly diagnosed or didn't have treatment during the last 3 months and patients who are currently treated but uncontrolled on…
- Trial name
- NCT00304226
- Testing
- valsartan, amlodipine
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,288 people, healthy volunteers welcome
- Sponsor
- Novartis
Uncontrolled Hypertension
Reducing Inequities in Care of Hypertension, Lifestyle Improvement for Everyone (RICH LIFE Project)
The RICH LIFE Project is a two-armed, cluster-randomized trial, comparing the effectiveness of an enhanced standard of care arm, "Standard of Care Plus" (SCP), to a multi-level intervention, "Collaborative Care/Stepped Care"…
- Trial name
- RICH LIFE (NCT02674464)
- Testing
- Provider Audit-Feedback, Stratified by Race and Ethnicity, Blood Pressure Measurement Standardization, System Level Leadership Intervention
- Where
- United States
- Volunteers
- 1,820 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Normal Blood Pressure, Controlled Hypertension
Wearable Evaluation of Ambulatory Readings for Blood Pressure
The purpose of this project is to compare the performance and validity of novel wearable technologies that measure blood pressure (BP) and physical activity with a Spacelabs Ambulatory Blood Pressure Monitoring (ABPM) device.
- Conditions
- Normal Blood Pressure, Controlled Hypertension, Uncontrolled Hypertension
- Trial name
- WEAR-BP (NCT06610448)
- Testing
- ABPMPro, Spacelabs Ambulatory Blood Pressure Monitoring, Aktiia Blood Pressure
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stephen Juraschek
Hypertension
Machine Learning to Reduce Hypertension Treatment Clinical Inertia
Among individuals with an uncontrolled BP at the current visit, the objective of this study is to compare clinical management of hypertension with and without information from a machine learning algorithm on whether a patient…
- Trial name
- NCT05406336
- Testing
- Predicted uncontrolled BP status (yes/no) at follow up visit, derived using a machine learning algorithm
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Temple University
Uncontrolled Hypertension
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of single and multiple ascending doses of QLS1410 in healthy Chinese adults and participants with mild…
- Trial name
- NCT07152444
- Testing
- QLS1410 (CYP11B2 inhibitor)
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Hypertension, Gut Microbiota
Metagenomic Analysis of Gut Microbiota in Untreated and Uncontrolled Hypertensive Patients
This observational study aims to explore the relationship between gut microbiota composition and blood pressure regulation in patients with hypertension.
- Trial name
- HyGut (NCT06284928)
- Testing
- Fecal Sample Collection
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Xinjiang Medical University
Uncontrolled Hypertension
Cystatin C and Uncontrolled Hypertension
Hypertension is an underdiagnosed and undertreated disease in real-life. Blood pressure and kidney functions are known to be closely related.
- Trial name
- NCT02334033
- Testing
- other
- Where
- Turkey (Türkiye)
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Ankara University
Hypertension
Pragmatic Trial Comparing Telehealth Care and Optimized Clinic-Based Care for Uncontrolled High Blood Pressure
This pragmatic trial will compare two team-based care models for managing hypertension, Best Practice Clinic-based Care and Telehealth Care with pharmacist management, in a large care system in Minnesota.
- Trial name
- NCT02996565
- Testing
- Best Practice Clinic-Based Care, Telehealth Care
- Where
- United States
- Volunteers
- 3,071 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute