Clinical trials: Unintentional Injury
Trauma Injury
Development of WHOLE Score
The aim of this study was to investigate the association between injury mechanism, physical examination findings, and laboratory parameters, and the presence of injuries involving multiple computed tomography (CT) regions on…
- Trial name
- WHOLE (NCT07411235)
- Where
- Turkey (Türkiye)
- Volunteers
- 407 people
- Sponsor
- Ankara City Hospital Bilkent
Trauma Injury, Trauma
Trauma Induced Coagulopathy and Inflammation
While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these…
- Conditions
- Trauma Injury, Trauma, Coagulopathy
- Trial name
- TrICI (NCT03128658)
- Testing
- Thromboelastography, Computational model
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Emergencies, Trauma Injury
Evaluation of the Course Format "NASIM25"
The investigators intend to evauate the development and professional safety of aspiring prehospital emergency pyhsicians in a cross sectional and longitudinal modality.
- Trial name
- NCT05295485
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Calcaneus Fracture, Displaced Intra-Articular Fracture of Calcaneus (Diagnosis)
Permissive Weight Bearing in Displaced Intra-articular Calcaneal Fractures
The goal of the proposed study is to define the optimal rehabilitation for trauma patients with Displaced Intra-articular Calcaneal Fractures, either Permissive Weight Bearing (PWB) or Restricted Weight Bearing (RWB) regarding…
- Conditions
- Calcaneus Fracture, Displaced Intra-Articular Fracture of Calcaneus (Diagnosis), Trauma Injury
- Trial name
- PIONEER (NCT05721378)
- Testing
- Permissive Weight Bearing group, Restricted Weight Bearing group
- Where
- 11 sites in Netherlands
- Volunteers
- 115 people
- Sponsor
- Maastricht University Medical Center
Rib Fractures, Rib Fracture Multiple
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death.
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
- Trial name
- UNPIN (NCT05865327)
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Trauma Injury
Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury
Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden.
- Trial name
- NCT02577731
- Testing
- Bone marrow collection, Blood collection, Clinical data collection
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Florida
Aging, Fall Injury
Medication Empowerment and Deprescription for Safety (MEDS) Study
The long-term goal of this pragmatic, cluster randomized study is to develop a sustainable program for healthcare systems to reduce fatal and nonfatal falls among high-risk older adults living independently in their communities.
- Trial name
- MEDS (NCT04612166)
- Testing
- Medication Action Plan and Patient Empowerment (MAP-PE )
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Iowa
Trauma Injury
Impairing Drugs and Alcohol as Risk Factors for Traumatic Injuries
Impairing drugs and alcohol are major risk factors for traumatic injuries. Still there is to date little knowledge to what extent these factors affect the epidemiology of trauma.
- Trial name
- IDART (NCT03773614)
- Where
- Norway
- Volunteers
- 5,000 people
- Sponsor
- Oslo University Hospital
Trauma Injury
Reducing Low-value Care for Trauma Admissions
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of…
- Trial name
- NCT05744154
- Testing
- Audit & feedback with educational outreach and facilitation, Simple audit & feedback (usual practice)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Laval University
Trauma Injury
ICG Fluorescence Imaging in Lower Extremity Amputation Patients
This is a non-randomized prospective study of 30 patients scheduled to undergo lower extremity amputation (below the knee, through the knee or above the knee) evaluating bone perfusion and viability using indocyanine green (ICG)…
- Trial name
- NCT04250558
- Testing
- Lower Extremity Amputation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
ICU, Trauma Injury
Current Situation and Analysis of ICU Management for Severe Trauma Patients in China
Over the past 10 years, there has not been a consensus on ICU nursing management based on the concept of injury control. Case management for patients with serious trauma continues to be initiated in general services and after…
- Conditions
- ICU, Trauma Injury, ICU Acquired Weakness
- Trial name
- NJJLISTP (NCT04944537)
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lulu Gu
Trauma Injury, Modified Trauma Scoring Systems
FOUR Score-Modified Trauma Scores for Mortality Prediction
The goal of this multicenter prospective observational cohort study is to develop and validate FOUR Score-modified trauma scoring systems for mortality prediction in adult trauma patients.
- Conditions
- Trauma Injury, Modified Trauma Scoring Systems, FOUR Score
- Trial name
- FOUR-TRAUMA (NCT07819279)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Non-compressible Torso Hemorrhage, Trauma Injury
Resuscitative Endovascular Balloon Occlusion of the Aorta in Haemorrhagic Shock
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a procedure that has the goal to stabilize trauma patients with non-compressible torso hemorrhage by temporarily occluding the aorta with a ballon catheter to…
- Trial name
- NCT05941572
- Where
- Austria
- Sponsor
- Medical University of Graz
Trauma Injury
Antibiotic Use in Facial Fracture Post Injury
Facial fractures make up a significant proportion of injuries in trauma patients (1, 2). Approximately 3 million individuals suffer craniofacial trauma in the United States on a yearly basis, and approximately 50% of all wounds…
- Trial name
- NCT04925531
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Methodist Health System
Accidental Injuries, Global Child Health
The P-KIDs CARE Health Systems Intervention in Tanzania
The objective of the proposed research is to develop and pilot a locally-relevant, multicomponent intervention to streamline the triage process (e.g.
- Conditions
- Accidental Injuries, Global Child Health, Pediatric Emergency Medicine, Public Health System Research
- Trial name
- P-KIDs CARE (NCT06075108)
- Testing
- P-KIDs CARE
- Where
- Tanzania
- Volunteers
- 284 people
- Sponsor
- University of Utah
Peripheral Artery Disease, Popliteal Aneurysm
Observational GORE® VIABAHN® Endoprosthesis With PROPATEN Bioactive Surface Global Registry
Collect real-world post-market clinical follow-up data on patients treated with the GORE® VIABAHN® Endoprosthesis with PROPATEN Bioactive Surface (VSX)
- Conditions
- Peripheral Artery Disease, Popliteal Aneurysm, Hemodialysis Access, Visceral Artery Aneurysms
- Trial name
- NCT04907240
- Testing
- GORE® VIABAHN® Endoprosthesis with PROPATEN Bioactive Surface (VSX)
- Where
- 26 sites in Belgium, France and 7 more
- Volunteers
- 614 people
- Sponsor
- W.L.Gore & Associates
Trauma Injury, Trauma Blunt
Extremity Trauma At a Level 1 Trauma Center
Blunt vascular trauma to the lower extremity has been associated with injuries to the anteroposterior tibial arteries or popliteal artery in the form of transection, occlusion, or intimal injury.
- Conditions
- Trauma Injury, Trauma Blunt, Vascular Trauma
- Trial name
- NCT06402669
- Testing
- Packed Red Blood Cell Administration
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Arrowhead Regional Medical Center
Postdural Puncture Headache, Post-Lumbar Puncture Headache
Incidence of Headache Following an Unintentional Dural Puncture
The purpose of this study is to evaluate the use of intrathecal morphine administration following an unintentional dural puncture, to decrease the incidence of post dural puncture headaches (PDPH) in obstetric patients.
- Conditions
- Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
- Trial name
- NCT01977898
- Testing
- Morphine, Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Trauma Injury, Trauma
OCT in Open Fracture and Infected Fracture
This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.
- Conditions
- Trauma Injury, Trauma, Open Fracture, Fracture Infection
- Trial name
- NCT05785182
- Testing
- Open Fracture, Infected Fracture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center