Clinical trials: Unipolar Disorder
Unipolar Depression, Bipolar Disorder
Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression
Intermittent and continuous theta-burst stimulation (iTBS and cTBS respectively) are the newer modalities of transcranial magnetic stimulation with documented efficacy in treatment of depressed mood but with conflicting results…
- Trial name
- NCT06371352
- Testing
- iTBS, cTBS
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Major Depressive Disorder, Unipolar, Non-psychotic Major Depressive Disorder
Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics
The purpose of this research is to see if information from blood and data from smartwatches can be combined to help diagnose depression and determine if transitions between active depression and treated depression can be…
- Trial name
- NCT05910957
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Unipolar Depression
Transcranial Direct Current Stimulation for Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
- Trial name
- NCT07042217
- Testing
- transcranial direct current stimulation (tDCS) and mindfulness instruction
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Depression Unipolar
Effects of tDCS-enhanced Cognitive Control Training on Depression
Deficient cognitive control (CC) is one of the central characteristics of major depression (MD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) has been linked with this deficit.
- Trial name
- NCT03518749
- Testing
- 1mA tDCS, 2mA tDCS, Cognitive control training
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Cognitive Impairments
Influence Factors and Cognitive Characteristics in Unipolar and Bipolar Depression:Based on the THINC-it Tool
Cognitive impairment is the core symptom of unipolar and bipolar depression, which seriously affects the prognosis of the disease and the rehabilitation of social function.
- Trial name
- NCT05053204
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Depression, Unipolar
Ketamine + Mindfulness for Depression
In this project, the investigators will administer a single infusion of IV ketamine to depressed patients and randomize the patients to receive either a) usual/typical infusion conditions or b) mindfulness training and exercises…
- Trial name
- NCT05168735
- Testing
- Intravenous Ketamine, Brief Mindfulness Exercises, Academic Exercises
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Rebecca Price
Chronic Unipolar Depressive Disorder
Trial of the Clinical and Cost Effectiveness of a Specialist Expert Mood Disorder Team for Refractory Unipolar Depressive Disorder
The purpose of this study is determine whether a specialised mood disorder service, which offers tailored psychological and pharmacological treatment, is more effective in the treatment of chronic unipolar depressive disorder…
- Trial name
- NCT01047124
- Testing
- Specialist Mood Disorders Team
- Where
- 3 sites in United Kingdom
- Volunteers
- 219 people
- Sponsor
- University of Nottingham
Affective Disorders, Unipolar Depression
Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials
Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological…
- Conditions
- Affective Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- RADMIS (NCT03033420)
- Testing
- A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Depressive Disorder, Major, Recurrence
Study Evaluating Venlafaxine ER in Recurrent Depression
The purpose of this study is to review the long-term comparative efficacy of venlafaxine ER in achieving and sustaining remission (wellness) in patients with recurrent major depression
- Trial name
- NCT00046020
- Testing
- Venlafaxine ER
- Volunteers
- 1,096 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mood Disorders, Healthy
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.
- Conditions
- Mood Disorders, Healthy, Unipolar Depression, Bipolar Depression
- Trial name
- NCT00055575
- Testing
- Scopolamine Nasal Spray
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Unipolar Depression
Depression Outcomes Study of Exercise
This pilot study may yield important research findings on how to adapt exercise treatment for depression among adolescents. Potential public health benefits from this study include a reduction of adolescent depression and…
- Trial name
- DOSE (NCT00964054)
- Testing
- Public Health Dose of Exercise (PHD), Low Dose Exercise (LD)
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Unipolar, Posttraumatic Stress Disorder
SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project
Despite carrying the vast majority of the global mental disorder burden, 75% of adults with mental disorders in Low and Middle Income Countries have no access to services.
- Conditions
- Depression, Unipolar, Posttraumatic Stress Disorder, Trauma
- Trial name
- SMART-DAPPER (NCT03466346)
- Testing
- Fluoxetine, Interpersonal Psychotherapy
- Where
- 3 sites in Kenya
- Volunteers
- 2,162 people
- Sponsor
- University of California, San Francisco
Depressive Disorder, Major, Depression
Pilot Study: Investigating Mood Changes After Slow-wave Enhancement
The aim of this pilot project proposal is to test the hypothesis that decreased sleep slow-wave activity (SWA) observed in individuals with major depressive disorder (MDD) is related to mood dysfunction, and that manipulating SWA…
- Conditions
- Depressive Disorder, Major, Depression, Depression, Unipolar, Depressive Disorder
- Trial name
- SWE (NCT05146427)
- Testing
- Slow-wave enhancement
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Imaging Antidepressant vs. Cognitive Behavior Therapy Effects on Unipolar Depression
Our goals are 1) to use functional magnetic resonance imaging (fMRI) to predict which depressed individuals will respond to different validated treatments for unipolar depression including Cognitive Therapy (CT) and…
- Trial name
- ssrifMRI (NCT00787501)
- Testing
- SSRI, CBT
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Pittsburgh
Depression, Unipolar, Treatment Resistant Depression
PF-04995274 and Emotional Processing in Treatment Resistant Depression
This study will test whether seven days adjunctive administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on emotional processing and non-emotional cognition in medicated…
- Trial name
- RESTART (NCT03515733)
- Testing
- PF-04995274
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Oxford
Major Depressive Disorder
A Closed-loop Assessment and Treatment Platform for Unipolar Depression and Anxiety
Specific Aim 1: Finalize development of the closed-loop strategy in the MMT application. Specific Aim 2: Evaluate the acceptability and feasibility of the MMT application with the target population to prepare for a large-scale…
- Trial name
- NCT02948036
- Testing
- Mobile-device, plasticity-based adaptive cognitive treatment
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Major Depressive Disorder
Family Psychoeducation for Major Depressive Disorder
The aim of the present study is to compare an intervention consisting of Family Psychoeducation (FPE) to an active control intervention of social support for relatives of patients with a diagnosis of major depression.
- Trial name
- NCT02348827
- Testing
- Family psychoeducation, Social support group
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depression
Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder
To evaluate the effectiveness of one algorithm for Major Depression Disorder (MDD) using medications available in the Brazilian Public Healthcare System (SUS), and assessment of the quality of life of these patients.
- Trial name
- NCT02901249
- Testing
- sertraline, Nortriptyline, Lithium
- Volunteers
- 68 people
- Sponsor
- Federal University of Rio Grande do Sul
Emotional Disorders, Anxiety
Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial
This adaptive randomized controlled trial evaluates the efficacy of a transdiagnostic, internet-delivered psychological intervention for emotional disorders, tailored to patient´s early clinical response.
- Conditions
- Emotional Disorders, Anxiety, Depression, Unipolar
- Trial name
- NCT07051148
- Testing
- UJI Online Transdiagnostic Protocol, UJI On Line Transdiagnostic Hibrid Protocol
- Volunteers
- 366 people
- Sponsor
- Universitat Jaume I