Clinical trials: Unipolar Disorder
Depressive Disorder, Major
Abilify as an Adjunctive Treatment for Refractory Depression
This is a study of the effectiveness of adding Abilify (aripiprazole), an atypical antipsychotic medication, to ongoing selective serotonin reuptake inhibitor (SSRI) antidepressant treatment for depressed outpatients who are not…
- Trial name
- NCT00220636
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Bipolar Disorder, Mood Disorder
Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders
This study is designed to evaluate repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for depression. In rTMS, a rapidly changing magnetic field passes through your scalp and skull and generates a small…
- Conditions
- Bipolar Disorder, Mood Disorder, Unipolar Depression
- Trial name
- NCT00001545
- Testing
- Magstim Super Rapid Magnetic Stimulator, Cadwell MES-10
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- National Institute of Mental Health (NIMH)
Resistant Depression, Moods Disorders
tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients
The aim is to investigate the effect of transcranial Direct Current Stimulation (tDCS) applied at the anodal left CDLPF of patients with resistant depression compared to patients treated with conventional therapy.
- Conditions
- Resistant Depression, Moods Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- STICODEP (NCT01644747)
- Testing
- transcranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator)
- Where
- 6 sites in France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dysthymic Disorder, Depressive Disorder NOS
Duloxetine for Chronic Depression: a Double-blind Study
The investigators are studying a new antidepressant medicine, duloxetine, for the treatment of people with chronic depression. Duloxetine (trade name Cymbalta) was recently approved by the FDA for the treatment of major…
- Trial name
- NCT00360724
- Testing
- Duloxetine (Cymbalta)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- New York State Psychiatric Institute
Treatment Resistant Depression (TRD)
Ketamine Biomarker Validation
An EEG-based biomarker will be developed for the effects of ketamine infusion in patients with Depression. The effects of ketamine infusion on Depression symptoms and EEG signals will be analyzed.
- Trial name
- NCT07307768
- Testing
- Ketamine (0.25 mg/kg), Ketamine (0.5 mg/kg), Ketamine (0.75 mg/kg)
- Where
- United States
- Sponsor
- Soterix Medical
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Unipolar
PF-04995274 and Emotional Processing in Un-medicated Depression
This study will test whether seven days administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on cognition, emotional processing and neural activity in unmedicated depressed…
- Trial name
- RESTAND (NCT03516604)
- Testing
- PF-04995274, Citalopram
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Oxford
Depression, Unipolar, Fall
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression
This study will test clinical and cost effectiveness of an integrated tele- and bachelor's-level counselor/coach delivered behavioral activation (BA) and fall prevention (FP) for low-income homebound older adults.
- Trial name
- TBF (NCT05011864)
- Testing
- Behavioral Activation, Fall Prevention, Telephone support
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Texas at Austin
Non-Psychotic Unipolar Depression, Bipolar Depression
Feasibility and Tolerability of Adjunct Chronotherapy in Depressed Inpatients
This study will attempt to study the effect of adjunctive chronotherapy (wake therapy, sleep phase advance, and bright light therapy) on acutely depressed inpatients.
- Trial name
- NCT02088580
- Testing
- Triple Chronotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medical University of South Carolina
Unipolar Depression, Anxiety Disorders
Effects of Mindfulness Based Cognitive Therapy on Emotional Processing
Background: In the last 30 years mindfulness-based approaches have been extensively used for a variety of mental disorders, including affective disorders characterized by emotional instability.
- Conditions
- Unipolar Depression, Anxiety Disorders, Adjustment Disorders, Emotional Instability
- Trial name
- MESI (NCT03358056)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Parc de Salut Mar
Depressive Disorder, Major, Depression, Bipolar
The Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression and Bipolar Depression
The study aimed to investigate whether transcranial direct current stimulation could improve depressive symptoms, neurocognitive function and modulate heart rate variability in unipolar and bipolar depression.
- Conditions
- Depressive Disorder, Major, Depression, Bipolar, Electricity; Effects
- Trial name
- NCT03287037
- Testing
- tDCS over DLPFC
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Unipolar Depression, Bipolar Disorder
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat.
- Trial name
- NCT06363981
- Testing
- Active rTMS over the left DLPFC and over the left DMPFC, Active rTMS over the left DLPFC
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jakub Antczak
Major Depressive Disorder, Social Anxiety Disorder
Transdiagnostic iCBT for Depression and Anxiety
This 8-week, pilot randomized, controlled trial to evaluate the benefits of transdiagnostic Internet-based CBT (iCBT) in young adults with MDD, SAD, PD or GAD.
- Conditions
- Major Depressive Disorder, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT02266693
- Testing
- iCBT
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Centre for Addiction and Mental Health
Depressive Disorder, Major
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
This is a randomised double-blind clinical trial. The aim is to compare the efficacy and mechanisms of action of psilocybin, the primary psychoactive substance in 'magic mushrooms', with the selective serotonin reuptake inhibitor…
- Trial name
- Psilodep-RCT (NCT03429075)
- Testing
- Psilocybin + Escitalopram
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Imperial College London
Unipolar Depression
Thinking Healthy Program - Peer Delivered, India (THPP-I)
Background The rates of perinatal depression in South Asian women are reported to be amongst the highest in the world, ranging from 18%-30% in urban areas and 28%-36% in rural areas.
- Trial name
- THPP-I (NCT02104232)
- Testing
- THPP-I, EUC
- Where
- India
- Volunteers
- 280 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Unipolar Depression
Validation of the Spanish Version of the Clinically Useful Depression Outcome Scale (CUDOS) Scale
The Clinically Useful Depression Outcome Scale (CUDOS) is a brief, self-administered instrument that not only evaluates depressive symptoms but also both functioning and quality of life.
- Trial name
- CUDOS (NCT01360307)
- Where
- 17 sites in Spain
- Volunteers
- 330 people
- Sponsor
- AstraZeneca
Depression, Unipolar, Cardiovascular Diseases
Lifestyle InterVEntion Study in General Practice: LIVES - GP
Patients with depression are at a substantially increased risk of chronic physical disease including cardiovascular disease. This may be attributed primarily to an unhealthy lifestyle related to their disorder.
- Trial name
- LIVES-GP (NCT06286345)
- Testing
- GLI-LEEF
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Unipolar Depression
Effect of Tao Calligraphy Meditation and Energized Water on Depression
The goal of this controlled randomized clinical study is to learn if a Tao Calligraphy Mindfulness and Energized water Practice works to improve Unipolar Depression.
- Trial name
- NCT06934330
- Testing
- Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love), Drinking Energized water
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sha Research Foundation
Depression
Riluzole to Treat Major Depression
This study will examine the safety and effectiveness of the drug riluzole (Rilutek® (Registered Trademark)) for short-term treatment of depression symptoms, such as depressed mood, psychomotor retardation, and excessive sleeping.
- Trial name
- NCT00026052
- Testing
- riluzole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Mental Health (NIMH)
Multiple Sclerosis (MS), Unipolar Depression
Mood Disorders in Multiple Sclerosis Patients
This study investigates the frequency of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic condition that affects the central nervous system, and previous research suggests that mood…
- Conditions
- Multiple Sclerosis (MS), Unipolar Depression, Bipolar Disorder, Mood Disorders
- Trial name
- MSMD (NCT06652308)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Islamic Azad University, Sanandaj