Clinical trials: Unipolar Disorder
Major Depressive Disorder, Major Depression
Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group
Our goal is to study pharmacogenetics in Mexican-Americans, using depression treatments as a proof of the concept that pharmacogenetic approaches can be used to optimize treatment strategies for common and complex disorders in…
- Conditions
- Major Depressive Disorder, Major Depression, Unipolar Depression
- Trial name
- NCT00265291
- Testing
- fluoxetine or desipramine
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Depression, Depressive Disorder, Major
A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise
This pilot study aims to test a model that predicts that enhanced neurotransmitter gamma-aminobutyric acid (GABA) function in reward and affect-regulation central nervous system (CNS) circuits mediates the antidepressant effects…
- Conditions
- Depression, Depressive Disorder, Major, Depressive Disorder, Unipolar Depression
- Trial name
- MEDEX (NCT02407704)
- Testing
- Venlafaxine XR, Aerobic Exercise, Lorazepam
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kirk Erickson, PhD
Unipolar Depression
The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression
Recently published work has examined the effects of "atypical antipsychotics" in SSRI-treatment resistant patients. In these studies, patients with unipolar depression who were treated with SSRI's, but not responsive to treatment…
- Trial name
- NCT00517387
- Testing
- Quetiapine XR
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Major Depression, Treatment Resistant Depression
Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial
The investigators aim to conduct a single-arm open-label clinical trial, meaning that the investigators will be administering a treatment protocol to one group of patients, where no information is withheld from trial…
- Trial name
- CombTMS (NCT06500533)
- Testing
- rTMS combined with tDCS
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Regionspsykiatrien Gødstrup
Heart Failure, Pacing
Model 4965 Post-Approval Study
Safety and effectiveness will be summarized for the model 4965 lead. This study was conducted within Medtronic's System Longevity Study (SLS).
- Conditions
- Heart Failure, Pacing, Bradycardia, Arrhythmia
- Trial name
- NCT01076348
- Where
- 107 sites in United States, Australia and 12 more
- Volunteers
- 73 people
- Sponsor
- Medtronic
Bipolar Radiofrequency Ablation, Unipolar Radiofrequency Ablation
Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain
This study aims to compare the efficacy of unipolar versus bipolar radiofrequency ablation (RFA) in knee osteoarthritis pain.
- Conditions
- Bipolar Radiofrequency Ablation, Unipolar Radiofrequency Ablation, Knee Osteoarthritis, Pain
- Trial name
- NCT07789340
- Testing
- Unipolar radiofrequency ablation, Bipolar radiofrequency ablation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Depressive Disorder, Depression, Unipolar
Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Symptoms After Hospital Discharge (Mind-WIN Pilot Study) (Mind-WIN Pilot)
Mind-WIN is a digitally supported (app- and web-based) aftercare program for young people between the ages of 12 and 17, which was developed for adolescent patients with depressive symptoms and is intended to be used after…
- Trial name
- MindWinPilot (NCT07007247)
- Testing
- Mind-WIN self-help only, Mind-WIN blended care
- Where
- 3 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf