Clinical trials: Unipolar Major Depression
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Depression, Unipolar
A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression
Antidepressants is the primary treatment for depression, but only less than 50% of the patients get clinical remission. There is no objective markers to select antidepressants for clinical treatment .
- Trial name
- NCT03623711
- Testing
- Escitalopram, Duloxetine, Bupropion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuqi Cheng
Depression, Unipolar
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
From 40 to 60% of patients with depression experience a rapid and significant improvement of mood with one night of sleep deprivation (SD). The neural mechanisms underlying this effect have not been elucidated.
- Trial name
- NCT03169543
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depressive Disorder, Healthy
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients.
- Trial name
- NCT00369798
- Testing
- PET scan, Rolipram
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Psychophysiologic Disorders, Stress, Psychological
MBCGT and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient
Cases of physical and psychological stress problems is the need to prevent the risk of depression, primary care model will help to prevent depression.
- Conditions
- Psychophysiologic Disorders, Stress, Psychological, Unipolar Depression
- Trial name
- NCT01894932
- Testing
- Mindfulness-based cognitive Group therapy, psycho-physiological stress regulation group
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Depression, Unipolar, Pain, Postoperative
Maternal Mindfulness: Depression and Postpartum Pain
This phase I clinical trial tests the feasibility and safety of a self-guided, mobile mindfulness-based intervention to reduce post-cesarean pain and prevent postpartum depression.
- Trial name
- MaMiDaPP (NCT05400382)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Major Depressive Disorder, Unipolar Depression
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; an estimated 20-40% of patients do not benefit sufficiently from existing antidepressant interventions…
- Conditions
- Major Depressive Disorder, Unipolar Depression, Depression
- Trial name
- DepressionDC (NCT02530164)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation
Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients
Depression is the leading cause of disability worldwide and around 800,000 suicides occur each year. According to the World Health Organization, major depressive disorder (MDD) is expected to be the leading cause of the global…
- Conditions
- Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation, Accelerated Protocol, Sham-controlled
- Trial name
- NCT06783361
- Testing
- Transcranial Magnetic Stimulation with figure-eight coil
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Bipolar Disorder, Unipolar Depression
Development of a Software Tool, Using Artificial Intelligence, That Integrates Clinical, Biological, Genetic and Imaging Data to Predict Diagnosis and Outcome of Depressed Patients in Order to Enhance Prognosis and Limiting Healthcare Costs.
Based on robust evidence from literature, the investigators hypothesize the presence of disease-specific neurobiological underpinnings for bipolar and unipolar disorder, which may serve as biomarkers for differential diagnosis.
- Trial name
- NCT05801562
- Where
- Italy
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depression, Major Depressive Disorder
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT
The purpose of the study is to learn more about computer-assisted cognitive behavioral therapy or "CCBT" and to examine connections in the brains of patients with depression.
- Conditions
- Depression, Major Depressive Disorder, Depressive Disorder, Depression, Unipolar
- Trial name
- NCT03096886
- Testing
- Computer-Augmented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Unipolar Depression
Natural Supplements for Unipolar Depression
This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
- Trial name
- NCT00226356
- Testing
- Supplements of L-methionine, betaine and folate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Unipolar Major Depression
Theta Burst Study Ghent
50 Right-handed antidepressant-free unipolar depressed patients (age 18-65 years) will be treated with in total 20 Theta burst sessions; these will be spread over 4 days.
- Trial name
- TBS Ghent (NCT01832805)
- Testing
- Theta burst stimulation.
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Depressive Disorder, Major, Treatment Resistant Depression
Stepped Care AiTBS 2 Depression Study (Ghent)
Antidepressant-free unipolar melancholic depressed patients (at least stage 2 treatment-resistant) will be selected by a certified psychiatrist, who will administer (semi-)structured clinical interviews.
- Conditions
- Depressive Disorder, Major, Treatment Resistant Depression, Melancholia
- Trial name
- aiTBS2-Ghent (NCT03288675)
- Testing
- aiTBS, CCT, SSRI
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Depression, Postpartum, Depression, Unipolar
Tracking Depression Symptoms With a Health Chatbot
The goal of this research is to bridge a significant "effectiveness" gap in the treatment of depression. The investigators have developed a chatbot which will assist in performing measurement-based care (MBC) via Facebook…
- Trial name
- NCT03990389
- Testing
- Chatbot Intervention
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Stress, Psychological, Anxiety Disorders
Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students
Mental health problems -particularly depression- are the main cause of morbidity in young people (1), which has a known association with different health and social problems, such as increased alcohol consumption and drug…
- Conditions
- Stress, Psychological, Anxiety Disorders, Depression, Unipolar
- Trial name
- NCT05114824
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- Chile
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Bipolar Disorder, Cognitive Impairment
Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders
The present trial consists of 2 sub-studies that investigate important novel aspects of treatment with erythropoietin (EPO) on cognitive dysfunction in bipolar disorder (BD) and recurrent unipolar depressive disorder (UD)…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Unipolar Depression
- Trial name
- PreTEC-EPO (NCT03315897)
- Testing
- Erythropoietin, Saline
- Where
- Denmark
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Lars Vedel Kessing
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation
Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression
In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing.
- Conditions
- Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation, Accelerated Protocol, Intermittent Theta Burst Stimulation
- Trial name
- NCT07264452
- Testing
- Transcranial Magnetic Stimulation with figure-eight coil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression
Brain Network Activation Analysis to Diagnose/Assess Treatment of Unipolar Major Depression and Bipolar I Depression
The investigators are conducting this study to test the usefulness of a new type of analysis of electroencephalographic (EEG) recordings called brain network activation or BNA.
- Trial name
- BNA-Mood (NCT01683214)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center