Clinical trials: Unipolar Major Depressive Disorder
Acute Depression, Major Depressive Episode
Study of Functional Networks in Resting fMRI
The primary purpose is to compare with resting fMRI the functional networks of rest (RTS) in unipolar depression and in bipolar depression.
- Trial name
- DEPIMAGE (NCT03323073)
- Testing
- Resting state fMRI
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Disorder, Bipolar Depression
PET and MRI Brain Imaging of Bipolar Disorder
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2.
- Conditions
- Bipolar Disorder, Bipolar Depression, Unipolar Depression
- Trial name
- NCT01880957
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Mood Disorders, Healthy
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.
- Conditions
- Mood Disorders, Healthy, Unipolar Depression, Bipolar Depression
- Trial name
- NCT00055575
- Testing
- Scopolamine Nasal Spray
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control…
- Trial name
- NCT00188942
- Testing
- Fluoxetine+Olanzapine, Olanzapine, Functional Magnetic Resonance Imaging
- Where
- 2 sites in Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder, Depression, Unipolar
A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression
Antidepressants is the primary treatment for depression, but only less than 50% of the patients get clinical remission. There is no objective markers to select antidepressants for clinical treatment .
- Trial name
- NCT03623711
- Testing
- Escitalopram, Duloxetine, Bupropion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuqi Cheng
Stress, Psychological, Anxiety Disorders
Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students
Mental health problems -particularly depression- are the main cause of morbidity in young people (1), which has a known association with different health and social problems, such as increased alcohol consumption and drug…
- Conditions
- Stress, Psychological, Anxiety Disorders, Depression, Unipolar
- Trial name
- NCT05114824
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- Chile
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Unipolar Depression, Bipolar Depression
Mechanism of Action of Electroconvulsive Therapy
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
- Trial name
- MoA-ECT (NCT04059952)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Bipolar, Depression, Unipolar
Chronobiology and Depression: Circadian Analytics as a Biomarker for Depressive Subtypes
An objective measure of treatment response could be a valuable new tool in the armamentarium of depression management, and this holds true for stimulation-based and pharmacological therapies alike.
- Conditions
- Depression, Bipolar, Depression, Unipolar, Healthy
- Trial name
- NCT03538275
- Testing
- Monitoring test
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medibio Limited
Depression, Unipolar
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
From 40 to 60% of patients with depression experience a rapid and significant improvement of mood with one night of sleep deprivation (SD). The neural mechanisms underlying this effect have not been elucidated.
- Trial name
- NCT03169543
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Unipolar Depression
Assesment of Retinal Nerve Fiber Layer in First Episode Depressive Patients Using Selective Serotonin Reuptake Inhibitor
The aim of this study is to assess the changes in retinal nerve fiber layer due to SSRI treatment in first-attack major depressive patients.
- Trial name
- NCT04717921
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mehmet Diyaddin Güleken
Unipolar Depression
The Effects of Sleep Deprivation on Antidepressant Response
This study will use positron emission tomography (PET) to examine the effect of sleep deprivation on brain function.
- Trial name
- NCT00178074
- Testing
- total sleep deprivation, PET imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bipolar Disorder, Unipolar Depression
Development of a Software Tool, Using Artificial Intelligence, That Integrates Clinical, Biological, Genetic and Imaging Data to Predict Diagnosis and Outcome of Depressed Patients in Order to Enhance Prognosis and Limiting Healthcare Costs.
Based on robust evidence from literature, the investigators hypothesize the presence of disease-specific neurobiological underpinnings for bipolar and unipolar disorder, which may serve as biomarkers for differential diagnosis.
- Trial name
- NCT05801562
- Where
- Italy
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depression, Major Depressive Disorder
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT
The purpose of the study is to learn more about computer-assisted cognitive behavioral therapy or "CCBT" and to examine connections in the brains of patients with depression.
- Conditions
- Depression, Major Depressive Disorder, Depressive Disorder, Depression, Unipolar
- Trial name
- NCT03096886
- Testing
- Computer-Augmented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Unipolar Depression
Natural Supplements for Unipolar Depression
This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
- Trial name
- NCT00226356
- Testing
- Supplements of L-methionine, betaine and folate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Bipolar Disorder, Major Depression
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder.
- Trial name
- NCT01811147
- Testing
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Depression, Unipolar
Validity and Reliability of Vietnamese Version of 17items-Hamilton Depression Rating Scale
this reseach examines the reliability and validity of 17 items- Hamilton Depression rating scale in Vietnamese population, which has been commonly used in clinical depression practice and study.
- Trial name
- NCT04205747
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depressive Disorder, Major Depression
Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group
Our goal is to study pharmacogenetics in Mexican-Americans, using depression treatments as a proof of the concept that pharmacogenetic approaches can be used to optimize treatment strategies for common and complex disorders in…
- Conditions
- Major Depressive Disorder, Major Depression, Unipolar Depression
- Trial name
- NCT00265291
- Testing
- fluoxetine or desipramine
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Depressive Disorder, Major, Treatment Resistant Depression
Stepped Care AiTBS 2 Depression Study (Ghent)
Antidepressant-free unipolar melancholic depressed patients (at least stage 2 treatment-resistant) will be selected by a certified psychiatrist, who will administer (semi-)structured clinical interviews.
- Conditions
- Depressive Disorder, Major, Treatment Resistant Depression, Melancholia
- Trial name
- aiTBS2-Ghent (NCT03288675)
- Testing
- aiTBS, CCT, SSRI
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent