Clinical trials: Unipolar Major Depressive Disorder
Unipolar Depression
Efficacy of Daylight as Adjunctive Treatment in Patients With Depression
The aim of this study is to improve the treatment effect for outpatients with depression by adding regular daily morning daylight exposure to their treatment with antidepressants.
- Trial name
- NCT04712968
- Testing
- Regular exposure to morning daylight
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Affective Disorders, Unipolar Depression
Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials
Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological…
- Conditions
- Affective Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- RADMIS (NCT03033420)
- Testing
- A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Depression, Unipolar
Validity and Reliability of Vietnamese Version of 17items-Hamilton Depression Rating Scale
this reseach examines the reliability and validity of 17 items- Hamilton Depression rating scale in Vietnamese population, which has been commonly used in clinical depression practice and study.
- Trial name
- NCT04205747
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Unipolar
Machine Learning to Predict Clinical Response to TMS
Major Depressive Disorder (MDD) is a common and debilitating illness. It affects a person's family and personal relationships, work, education, and life.
- Trial name
- LEARN (NCT03847688)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brown University
Depression Unipolar
Effects of tDCS-enhanced Cognitive Control Training on Depression
Deficient cognitive control (CC) is one of the central characteristics of major depression (MD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) has been linked with this deficit.
- Trial name
- NCT03518749
- Testing
- 1mA tDCS, 2mA tDCS, Cognitive control training
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Unipolar Depression, Bipolar Depression
Berlin Magnetic Seizure Therapy Depression Trial 01
This treatment pilot study will investigate clinical efficacy and adverse effects of magnetic seizure therapy (MST) in patients currently experiencing a unipolar or bipolar depressive episode.
- Trial name
- NCT00914680
- Testing
- magnetic seizure therapy
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Charite University, Berlin, Germany
Acute Depression, Major Depressive Episode
Study of Functional Networks in Resting fMRI
The primary purpose is to compare with resting fMRI the functional networks of rest (RTS) in unipolar depression and in bipolar depression.
- Trial name
- DEPIMAGE (NCT03323073)
- Testing
- Resting state fMRI
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression
Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression
The purpose of this study is to investigate whether patients with depression should be offered vitamin D supplements, or it has no significance in relation to treatment outcomes.
- Trial name
- D3-vit-dep (NCT01390662)
- Testing
- Vitamin D3
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Region Syddanmark
Major Depression
Zinc Supplementation of Imipramine Therapy
Examination of the effect of zinc supplementation on imipramine therapy in major depression.
- Trial name
- NCT00693680
- Testing
- Zincas Forte
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Polish Academy of Sciences
Unipolar Depression
Lamotrigine Augmentation in Resistant Depression
This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both prior non-response and prospective failure…
- Trial name
- NCT00901407
- Testing
- lamotrigine, paroxetine
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Depression, Unipolar, Depression, Bipolar
IM Ketamine vs Midazolam for Suicidal ER Patients
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide.
- Conditions
- Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
- Trial name
- NCT04640636
- Testing
- Ketamine hydrochloride injection, Midazolam injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Depression, Unipolar
Low-Dose Naltrexone (LDN) for Depression Relapse and Recurrence
The purpose of this pilot study is to determine if taking a low dose of naltrexone in addition to an antidepressant medication can help treat relapse or recurrence in people with Major Depressive Disorder (MDD). The U.S.
- Conditions
- Major Depressive Disorder, Depression, Unipolar, Recurrence, Relapse
- Trial name
- NCT01874951
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Depression
Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression
This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression.
- Trial name
- NCT00602290
- Testing
- Citalopram, Methylphenidate (MPH)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of California, Los Angeles
Depression, Unipolar
FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction.
- Trial name
- NCT05640089
- Testing
- fMRI-based neurofeedback
- Where
- 3 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Treatment Resistant Depression, Electroconvulsive Therapy
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as…
- Conditions
- Treatment Resistant Depression, Electroconvulsive Therapy, ECT, Ketamine
- Trial name
- ELEKT-D (NCT03113968)
- Testing
- electroconvulsive therapy (ECT), Ketamine
- Where
- 5 sites in United States
- Volunteers
- 403 people
- Sponsor
- Bo Hu
Depression, Suicide
Ketamine for Depression and Suicide Risk
The purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S.
- Trial name
- Ketamine (NCT02094898)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Unipolar Depression
Transcranial Direct Current Stimulation for Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
- Trial name
- NCT07042217
- Testing
- transcranial direct current stimulation (tDCS) and mindfulness instruction
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Depressive Disorder, Depression, Unipolar
Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression
This study aims to evaluate the acute and subacute effects of an inhaled N, N-Dimethyltryptamine (DMT) in patients with partial response in depression.
- Trial name
- NCT06094907
- Testing
- N,N-Dimethyltryptamine
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Major Depressive Disorder
Antidepressant Incomplete Response Depression
Observational, non-interventional, longitudinal, prospective,multicenter, open label (No treatment is involved). 3 assessment will be carried out .
- Trial name
- DRIA (NCT00782964)
- Where
- 48 sites in Spain
- Volunteers
- 364 people
- Sponsor
- AstraZeneca