Clinical trials: Unruptured Intracranial Aneurysm
Intracranial Sacciform Aneurysm
Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation.
- Trial name
- AneBiote (NCT05914636)
- Testing
- analysis of foecal microbiota
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Aneurysm Unruptured
Development Platform Construction and Application Promotion of Drug-Eluting Stents for Intracranial Aneurysm Interventional Therapy
This study is a post-marketing clinical study of the Lattice Flow-Diverting Dense-Mesh Stent. It plans to enroll 280 patients, who will be treated for unruptured intracranial aneurysms using the Lattice Flow-Diverting Dense-Mesh…
- Trial name
- NCT07190781
- Testing
- Flow-Diverting Dense-Mesh Stent
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Xinjian Yang
Intracranial Aneurysm
Interest of Pre-operative Use of 3D Printing for Endovascular Treatment of Unruptured Intracranial Aneurysms With Intrasaccular Flow Disruptor
This is a preliminary randomised controlled trial comparing the use of pre-operative 3D models to select an intrasaccular flow disruptor for endovascular aneurysm cure.
- Trial name
- ILIAD (NCT05665309)
- Testing
- 3D anatomical model of aneurysm
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Brain Aneurysm
Trial on Endovascular Aneurysm Management
The management of patients with unruptured aneurysms is controversial. Patients with unruptured aneurysms may suffer intracranial hemorrhage, but the incidence of this event is still debated.
- Trial name
- TEAM (NCT00537134)
- Testing
- Embolization, coiling
- Where
- 9 sites in United States, Canada and 2 more
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysms, Antiplatelet Drugs
Comparison of the Antiplatelet Efficacy of Aspirin Combined With Clopidogrel and Aspirin Combined With Half-dose Ticagrelor in Patients With Unruptured Intracranial Aneurysms With Normal CYP2C19 Metabolizer Phenotype
The goal of this clinical trial is to compare the antiplatelet efficacy of aspirin combined with clopidogrel and aspirin combined with half-dose ticagrelor in in patients with unruptured intracranial aneurysms with normal CYP2C19…
- Trial name
- NCT06486363
- Testing
- Aspirin combined with clopidogrel, Aspirin combined with half-dose ticagrelor
- Volunteers
- 196 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Intracranial Aneurysm
Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China
The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population…
- Trial name
- NCT00926172
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Intracranial Aneurysm
Pivotal Study of the Silk Vista Baby Flow Diverters in the Treatment of Unruptured Intracranial Aneurysms (PIONEER)
The PIONEER Study is a pivotal, multi-center, prospective, single-arm study designed to evaluate the safety and efficacy of the Silk Vista Baby (SVB) Flow Diverter for the treatment of unruptured aneurysms.
- Trial name
- PIONEER (NCT07225075)
- Testing
- Silk Vista Baby (SVB) Flow Diverter
- Where
- 6 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Balt USA
Aneurysm Cerebral, Bifurcation
LUMENS-1 EU EFS CIP
The primary objective of this clinical investigation is to evaluate the early safety and feasibility of the LuSeed Aneurysm Embolization System for treating unruptured intracranial aneurysms (IA).
- Conditions
- Aneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular Aneurysm
- Trial name
- NCT06761365
- Testing
- LuSeed Aneurysm Embolization System
- Where
- 6 sites in Bulgaria, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- LuSeed Vascular LTD.
Intracranial Aneurysm
A Feasibility Study to Evaluate the Safety and Effectiveness of Implantation of Flowise Cerebral Flow Diverter (Flowise)
The purpose of this study is to evaluate the safety and short-term effectiveness of implantation of 'Flowise Cerebral Flow Diverter' for the treatment of unruptured wide-necked cerebral aneurysm in the internal carotid artery.
- Trial name
- NCT02609867
- Testing
- Flowise Cerebral Flow Diverter
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Ruptured and Unruptured Intracranial Aneurysms
Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEB™ Aneurysm Embolization System
Flow disruption is a new endovascular approach for treatment of both ruptured and unruptured intracranial aneurysms, which involves placement of an endosaccular device (WEB) which modifies the blood flow at the level of the neck…
- Trial name
- NCT03312725
- Testing
- WEB aneurysm embolization system
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- Medical Therapy Solutions
Unruptured Intracranial Wide-neck Bifurcation Aneurysms
Flow Diverter Versus Conventional Endovascular Treatment for Unruptured Wide-Neck Bifurcation Aneurysms (FD-BWA Trial)
Brief Summary： The goal of this clinical trial is to compare whether the traditional approach (stent-assisted coiling) is associated with a lower complication rate than flow diverter (Pipeline™) treatment for unruptured…
- Trial name
- FD-BWA (NCT07707076)
- Testing
- Flow Diverter Group, Stent Assisted Coiling Group
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Unruptured Intracranial Aneurysm, Headache
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Headache Following Stent-Assisted Coiling of Unruptured Intracranial Aneurysms
The goal of this clinical trial is to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in reducing postoperative headache among adults undergoing stent-assisted coiling for unruptured…
- Conditions
- Unruptured Intracranial Aneurysm, Headache, Vagus Nerve Stimulations
- Trial name
- IMPACT-HT (NCT07479082)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysms, Wide Neck Intracranial Aneurysms
Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms
This is a multi-center, prospective, propensity matched twin armed study conducted on 50 patients in the experimental arm followed for 18 months after intervention evaluating cost effectiveness, safety and efficacy of therapy.
- Trial name
- CLASS (NCT05636124)
- Testing
- Kaneka i-ED coil
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ruptured Cerebral Aneurysm, Unruptured Cerebral Aneurysm
Microsurgical Clipping and Endovascular Embolization Comparative Prospective Randomized Trial
Despite the active development of surgical methods of treatment (endovascular embolization and microsurgical clipping) of cerebral aneurysms, determining the indications and method of surgical treatment of cerebral aneurysms…
- Trial name
- MONICA (NCT04548856)
- Testing
- Microsurgical clipping, Endovascular embolization
- Volunteers
- 4 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Cerebral Aneurysm
A Medical Device to Treat Brain Aneurysms
An aneurysm is a bulge in a blood vessel caused by a weakness in the blood vessel wall, usually where it branches. As blood passes through the weakened blood vessel, the blood pressure causes a small area to bulge outwards like a…
- Trial name
- NCT04963933
- Testing
- Nautilus endovascular device
- Where
- 2 sites in Bulgaria, Latvia
- Volunteers
- 30 people
- Sponsor
- EndoStream Medical
Aneurysm Cerebral (Unruptured)
Multimodal Approach Feasability Study for Untreated and Unruptured Intracranial Aneurysms
This feasibility study aims to evaluate the SYLVER system's ability to visualize intracranial aneurysms in accordance with 3D rotational angiography (3DRA) as the reference technique.
- Trial name
- miniCAN (NCT07864389)
- Testing
- 3D CEUS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Resolve Stroke
Intracranial Aneurysm
Evaluation of Postoperative Cognitive Function, Anxiety, Depression and Quality of Life in Patients With Unruptured Intracranial Aneurysms
This prospective single-center cohort study aims to identify the incidence of cognitive dysfunction after unruptured aneurysm operation and explore the influencing factors.
- Trial name
- NCT03494608
- Volunteers
- 350 people
- Sponsor
- Xuanwu Hospital, Beijing
Self Efficacy, Medical Device Complication
Chinese Registry of Assisted Embolization for Unruptured Wide Necked Intracranial Aneurysm Using LVIS Stent
This study aims to investigating the efficacy and safety of low profile visualized intraluminal support (LVIS) stents for the treatment of unruptured intracranial saccular aneurysms.
- Trial name
- CRANIAL-1 (NCT02830373)
- Testing
- LVIS stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Intracranial Aneurysm
The Helsinki Unruptured Intracranial Aneurysm Quality of Care Study
A research-initiated prospective cohort study with the aim to assess the effectivity, safety and long-term outcomes after surgical and endovascular treatment of unruptured intracranial aneurysms.
- Trial name
- HUIQE (NCT06147102)
- Testing
- Surgery, Endovascular
- Where
- Finland
- Volunteers
- 173 people
- Sponsor
- Helsinki University Central Hospital