Clinical trials: Unruptured Intracranial Aneurysms
Aneurysm Cerebral, Bifurcation
LUMENS-1 EU EFS CIP
The primary objective of this clinical investigation is to evaluate the early safety and feasibility of the LuSeed Aneurysm Embolization System for treating unruptured intracranial aneurysms (IA).
- Conditions
- Aneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular Aneurysm
- Trial name
- NCT06761365
- Testing
- LuSeed Aneurysm Embolization System
- Where
- 6 sites in Bulgaria, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- LuSeed Vascular LTD.
Intracranial Aneurysms, Unruptured Intracranial Aneurysm
ANEURYSM@RISK: Automatic Intracranial Aneurysm Quantification and Feature Learning Modelling to Optimize Intracranial Aneurysm Rupture Prediction
ANEURYSM@RISK is an observational study aiming to develop and validate an artificial intelligence (AI)-based prediction model for the growth and rupture of intracranial aneurysms (IAs).
- Conditions
- Intracranial Aneurysms, Unruptured Intracranial Aneurysm, Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
- Trial name
- NCT07111975
- Where
- Netherlands
- Volunteers
- 3,800 people
- Sponsor
- UMC Utrecht
Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation
Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations
A new endovascular route for the treatment of brain AVMs may be possible in some cases: Trans-Venous Embolization (TVE). The technique uses microcatheters to navigate to the draining veins of AVM, to reach and then fill the AVM…
- Conditions
- Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation
- Trial name
- TATAM (NCT03691870)
- Testing
- Standard Trans-Arterial Embolization (TAE), Trans-Venous Embolization (TVE)
- Where
- 9 sites in Canada, France
- Volunteers
- 77 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Saccular Aneurysm, Intracranial Aneurysm
Comprehensive Aneurysm Management Trial
The uncertainty regarding the management of Unruptured Intracranial Aneurysms (UIAs) has not progressed in the last 30 years. The fundamental ethical basis for this study is that physicians should only offer a risky preventive…
- Conditions
- Saccular Aneurysm, Intracranial Aneurysm, Unruptured Cerebral Aneurysm
- Trial name
- CAM (NCT04155606)
- Testing
- microsurgery; endovascular interventions
- Where
- 6 sites in Canada, France and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ruptured and Unruptured Intracranial Aneurysms
Safety and EffecTiveness of the Silk Vista Flow DiverteR in the TrEatment of Unruptured IntracrAnial AneurysMs
Intracranial aneurysms (IA) are abnormal outpouchings of cerebral arteries' walls that occur mostly in arteries found in the Circle of Willis and the middle cerebral artery bifurcation with a risk of rupture leading to…
- Trial name
- STREAM (NCT07073118)
- Testing
- Endovascular treatment with placement of a flow-diverting stent
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Unruptured Cerebral Aneurysm, Artificial Intelligence (AI)
AI Models for Cerebral Aneurysms Segmentation, Detection and Stability Prediction
Aneurysmal subarachnoid hemorrhage (SAH) is one of the critical diseases that severely threaten human health, with a clinical mortality rate reaching as high as 30%.
- Conditions
- Unruptured Cerebral Aneurysm, Artificial Intelligence (AI), Subarachnoid Hemorrhage, Aneurysmal, Magnetic Resonance Angiography
- Trial name
- AI-CARE (NCT06766422)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Unruptured Intracranial Aneurysm, Infarction Cerebral
Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms
1. Disease Description Stent-assisted coiling has become an effective treatment modality for intracranial aneurysms. With continuous advancements in periprocedural antiplatelet regimens, the incidence of symptomatic…
- Trial name
- CRISIS (NCT06826144)
- Testing
- remote ischemic conditioning
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cerebral Aneurysm Unruptured, Cerebral Aneurysm
Parent Artery Reconstruction for Small Unruptured Cerebral Aneurusms Using Flow DiverTers: a Multicenter Randomized Trial(PARAT-MT)
A prospective, multicenter, randomized controlled clinical trial with open-label treatment and blinded endpoint assessment.
- Trial name
- NCT06600997
- Testing
- Flow Diversion for Endovascular Treatment of Intracranial Aneurysms, Conventional endovascular therapy (stent-assisted coiling, balloon-assisted coiling, or coiling) for endovascular treatment of intracranial aneurysms
- Volunteers
- 1,008 people
- Sponsor
- Changhai Hospital
Unruptured Intracranial Aneurysm
Patients with Unruptured IntraCranial ANeurysms: Evaluation of the Benefits of Allied Health FollOw-uP in a RandomizEd Controlled Trial
The CANHOPE study falls within the scope of research on patients' experiences and the improvement of their management through interventions meeting their needs.
- Trial name
- CANHOPE (NCT06708078)
- Testing
- Follow-up according to the Canhope allied health support program
- Where
- France
- Volunteers
- 340 people
- Sponsor
- Nantes University Hospital
Aneurysm Cerebral (Unruptured)
Dual Antiplatelet Therapy Adherence With Reminder App Usage
The purpose of this study is to evaluate Dual Antiplatelet Therapy adherence in patients undergoing stent-based endovascular treatment for unruptured cervical and intradural, intracranial aneurysms.
- Trial name
- NCT05071027
- Testing
- Endovascular Neurosurgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Montefiore Medical Center
Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation
Treatment of Brain AVMs (TOBAS) Study
The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of…
- Conditions
- Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM
- Trial name
- TOBAS (NCT02098252)
- Testing
- Neurosurgery, Radiation therapy, Embolization
- Where
- 30 sites in United States, Brazil and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysm, Brain Aneurysm
The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices
Intracranial bifurcation aneurysms are commonly repaired with surgical and with endovascular techniques. Wide-necked bifurcation aneurysms (WNBA) are a difficult subset of aneurysms to successfully repair endovascularly, and a…
- Conditions
- Intracranial Aneurysm, Brain Aneurysm, Unruptured Cerebral Aneurysm, Ruptured Cerebral Aneurysm
- Trial name
- RISE (NCT03936647)
- Testing
- surgical clipping, simple coiling, high-porosity stenting with/ without coiling, intra-arterial flow diversion with/ without coiling, WEB embolization device
- Where
- 4 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Unruptured Cerebral Aneurysm
Remote Ischemic PreConditioning (RIPC)
The purpose of this study is to learn about protecting the brain from low blood flow (ischemia) with limb preconditioning. From human studies the investigators know that the brain can be protected from dangerous low blood flow by…
- Trial name
- NCT03814850
- Testing
- Standard Manual Aneroid Sphygmomanometer
- Where
- 2 sites in United States
- Sponsor
- Sebastian Koch
Unruptured Wide-neck Intracranial Aneurysms
A Study Evaluating the Safety and Effectiveness of the PulseRider® Aneurysm Neck Reconstruction Device Used in Conjunction With Endovascular Coil Embolization in the Treatment of Wide-Neck Bifurcation Intracranial Aneurysm
This is a prospective, multi-center, non-randomized clinical evaluation utilizing the PulseRider® Aneurysm Neck Reconstruction Device.
- Trial name
- NAPA (NCT03383666)
- Testing
- PulseRider® Aneurysm Neck Reconstruction Device
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Pulsar Vascular
Unruptured Intracranial Aneurysm, Arteriovenous Cerebral Malformations
ACtive Catheterization for EndovaScular TreatmentS
The objective of this clinical investigation is to evaluate the safety and technical success of the Basecamp Vascular controllable directional GECKO guidewire when used to facilitate endovascular access to the targeted vessel in…
- Conditions
- Unruptured Intracranial Aneurysm, Arteriovenous Cerebral Malformations, Carotid Stenosis
- Trial name
- ACCESS (NCT05355259)
- Testing
- GECKO Active Guidewire
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Basecamp Vascular
Aneurysm, Intracranial Aneurysm
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves.
- Conditions
- Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- APPLY (NCT04499508)
- Testing
- Optima Coil System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vascular Neurology of Southern California Inc.
Intracranial Saccular Aneurysm, Either Rupture or Unruptured, Wide Neck Aneurysm
Solitaire Aneurysm Remodeling Registry
The objective of the registry is to evaluate the effectiveness and performance of the Solitaire Neurovascular Remodeling Device when used with embolic coils in the treatment of intracranial aneurysms.
- Trial name
- NCT04905303
- Where
- France
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Unruptured Intracranial Aneurysms
Analysis of Thrombo-embolic Complications After Endovascular Treatment of Unruptured Intracranial Aneurysms
Endovascular treatment of ruptured and unruptured intracranial aneurysms presents complications, mainly the thrombo-embolic complication.
- Trial name
- ACET (NCT02862756)
- Testing
- diffusion-weighted MRI and clinical examination
- Where
- France
- Volunteers
- 250 people
- Sponsor
- CHU de Reims
Ruptured Cerebral Aneurysm, Unruptured Cerebral Aneurysm
Microsurgical Clipping and Endovascular Embolization Comparative Prospective Randomized Trial
Despite the active development of surgical methods of treatment (endovascular embolization and microsurgical clipping) of cerebral aneurysms, determining the indications and method of surgical treatment of cerebral aneurysms…
- Trial name
- MONICA (NCT04548856)
- Testing
- Microsurgical clipping, Endovascular embolization
- Volunteers
- 4 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Unruptured Intracranial Aneurysm, Stents
Application of Platelet Function Test in Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms
This study was designed to identify high platelet reactivity (HPR) who might have in-stent thrombosis in unruptured aneurysm with intracranial stent placement with light transmittance platelet aggregometry (LTA).
- Conditions
- Unruptured Intracranial Aneurysm, Stents, Antiplatelet Drugs
- Trial name
- APISIA Trail (NCT03989557)
- Testing
- Aspirin and clopidogrel/Ticagrelor, Light transmittance aggregometry
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Beijing Neurosurgical Institute