Clinical trials: Unspecified Mood Disorder
Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified
Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited for issues such as refractoriness and adverse effects.
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified, Major Depressive Disorder, Single Episode, Unspecified
- Trial name
- ELECT-TDCS (NCT01894815)
- Testing
- Escitalopram oxalate, transcranial direct current stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 245 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
Neurobiology of Treatment Responses in MDD
The primary study intent is to examine biological mechanisms associated with acute and chronic treatment responses in major depressive disorder (MDD).
- Trial name
- NCT03068247
- Testing
- Duloxetine
- Where
- United States
- Sponsor
- University of Utah
Major Depressive Disorder, Recurrent, Unspecified, Major Depressive Disorder, Single Episode, Unspecified
Prospective Multicenter Trial to Explore the Tolerability and Safety of the H-Coil Deep TMS in Combination With Serotonin Selective Reuptake Inhibitor(SSRI)
The purpose of the study is to explore the Tolerability and Safety of the H-Coil deep Transcranial Magnetic Stimulation (TMS) in combination with Serotonin Selective Reuptake Inhibitor (SSRI) for Subjects with Major Depression…
- Trial name
- NCT01361815
- Testing
- H-Coil Deep TMS in combination with SSRIs
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 75 people
- Sponsor
- Brainsway
First Episode Psychosis, Schizophrenia, Childhood
Early Psychosis Intervention - Spreading Evidence-based Treatment
Implementation of 'NAVIGATE' in Ontario aims to help youth and emerging adults suffering from a first episode of psychosis. Although Ontario already has early psychosis intervention programs, the team's recent work has identified…
- Conditions
- First Episode Psychosis, Schizophrenia, Childhood, Psychosis, Schizophrenia
- Trial name
- EPI-SET (NCT03919760)
- Testing
- NAVIGATE, Treatment as Usual
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Recurrent, Unspecified
Deep Brain Stimulation of Nucleus Accumbens for Chronic and Resistant Major Depressive Disorder
Depression is a common, recurrent and disabling disorder. Among patients with a chronic course of the disease, 20 to 30% are resistant to antidepressant medications.
- Trial name
- PRESTHYM (NCT01569711)
- Testing
- Deep brain stimulation of nucleus accumbens
- Where
- 10 sites in France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Psychosis, Psychosis Nos/Other
EPI-MINN: Targeting Cognition and Motivation - National
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using…
- Conditions
- Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05877716
- Testing
- Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Minnesota
Depression, Bipolar Disorder
Mitochondrial Dysfunction, Inflammation, and White Matter Integrity in Youth With Mood Disorders
This study consists of three separate appointments including a clinical assessment (interview and questionnaires), a blood draw, a social stress test, and a brain MRI.
- Conditions
- Depression, Bipolar Disorder, Bipolar Disorder Not Otherwise Specified, Unspecified Mood Disorder
- Trial name
- NCT02596698
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior
Rituximab Treatment for Psychosis And/or Obsessive Compulsive Disorder with Probable Immune System Involvement
The primary objective for this study is to evaluate whether Rituximab as compared to placebo is a clinically effective treatment for a subgroup of patients suffering from psychosis and/or obsessive-compulsive disorder (OCD) or…
- Conditions
- Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior, Schizophrenia, Delusional Disorder
- Trial name
- Ra-P-OCD (NCT04323566)
- Testing
- Rituximab
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Bipolar I Disorder, Unspecified, With Psychotic Features, Bipolar I Disorder, Unspecified, Without Psychotic Features
Psychosis and Affective Research Domains and Intermediate Phenotypes
The objective of this multi-site research collaboration is to test the manifestation and distribution of biological markers for psychosis and affect dimensions across the schizophrenia/bipolar (SZ-BD) diagnostic boundary, and to…
- Trial name
- PARDIP (NCT02218853)
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Oxytocin + Non Specific Counselling, Oxytocin + Social Skills Training
Administrating Oxytocin to Treat Treatment Schizophrenia and Schizo-affective Patients
The objectives of the study are: 1. To evaluate the effect of OT compared to placebo, as add-on to anti-psychotics, on social functioning in schizophrenia. 2.
- Conditions
- Oxytocin + Non Specific Counselling, Oxytocin + Social Skills Training, Placebo + Non Specific Counselling, Placebo + Social Skills Training
- Trial name
- OXY-S-01 (NCT01598623)
- Testing
- Oxytocin, Social Skills Training
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Sheba Medical Center
Major Depressive Disorder, Recurrent, Unspecified
Multiple Ascending Dose Study in Healthy Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY03005
Objectives To evaluate the safety and tolerability of escalating multiple oral doses of LY03005 in healthy subjects. To characterize the pharmacokinetics of escalating multiple oral doses of LY03005.
- Trial name
- NCT02271412
- Testing
- LY03005
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Schizophrenia, Schizotypal Disorder
Feasibility of a Novel Process-based Treatment for Patients With Psychosis
The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- PROBAS (NCT04874974)
- Testing
- Metacognitive and Defusion Training
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Anxiety Depression (Mild or Not Persistent), Major Depressive Disorder, Single Episode, Unspecified
Self-Management for Anxiety, Depression and Somatoform Disorders
Anxiety, Depression and Somatoform disorders are highly prevalent in primary care. Very often these conditions remain undiscovered and/or untreated.
- Conditions
- Anxiety Depression (Mild or Not Persistent), Major Depressive Disorder, Single Episode, Unspecified, Neurotic, Stress-related and Somatoform Disorders
- Trial name
- SMADS (NCT01726387)
- Testing
- Psychosocial Counseling, Usual Care
- Where
- Germany
- Volunteers
- 364 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Single Episode, Unspecified
Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents
In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major…
- Trial name
- NCT02078258
- Testing
- ABMT
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Hunan Normal University
Unspecified Child Maltreatment, Suspected, Unspecified Child Maltreatment, Confirmed
Northwell Health Visits: A Family Connects Pilot Implementation at Northwell Health
Northwell Health Visits (NHV) is a three year pilot replication of the evidence-based model, Family Connects, which is a brief universal Nurse Practitioner home visiting program for new mothers and their infants.
- Conditions
- Unspecified Child Maltreatment, Suspected, Unspecified Child Maltreatment, Confirmed, Postpartum Depression
- Trial name
- NCT03887910
- Testing
- Enhanced Intervention, Intervention
- Where
- United States
- Volunteers
- 840 people
- Sponsor
- Northwell Health