Clinical trials: Untreated
Pancreatic Cancer
R115777 in Treating Patients Who Have Metastatic Pancreatic Cancer
Phase II trial to study the effectiveness of R115777 in treating patients who have metastatic pancreatic cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005843
- Testing
- tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Blood Pressure
The Impact of Hospitalization on Ambulatory Blood Pressure and Intraocular Pressure
The purpose of this study is to assess the effect of hospital admission on 24-hour ambulatory blood pressure (ABP) in hypertensive subjects.Treated or untreated hypertensive adults with open angle glaucoma underwent in-hospital…
- Trial name
- NCT01029860
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Hepatocellular Carcinoma
A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma
This study will evaluate the efficacy and safety of atezolizumab plus bevacizumab combined with on-demand TACE compared to on-demand TACE alone in participants with hepatocellular carcinoma who are at high risk of poorer outcome…
- Trial name
- NCT04712643
- Testing
- Atezolizumab, Becavizumab, Transarterial chemoembolization (TACE)
- Where
- 40 sites in China, Japan
- Volunteers
- 342 people
- Sponsor
- Hoffmann-La Roche
Extensive Stage Small Cell Lung Cancer
Cisplatin, Etoposide, and Bevacizumab in Treating Patients With Previously Untreated Extensive Stage Small Cell Lung Cancer
This phase II trial is studying how well giving cisplatin and etoposide together with bevacizumab works in treating patients with previously untreated extensive-stage small cell lung cancer.
- Trial name
- NCT00079040
- Testing
- cisplatin, etoposide, bevacizumab
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Visible Light Exposures on Healthy Back Skin
Photoprotection Efficacy of a Sunscreen Under Visible Light Exposure by Using Two Different Simulators
To assess the ability of a protected agent to prevent the pigmentation under visible light exposures (VL) using two different simulators in healthy volunteers
- Trial name
- NCT06796140
- Testing
- Visible Light Exposure - Treated zone - Left hemi-back, Visible Light Exposure - Treated zone - Right hemi-back, Visible Light Exposure - Untreated zone - Left hemi-back
- Where
- Romania
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Cancer Survivor, Leukemia
Study of Long-Term Outcomes of Patients With Acute Lymphoblastic Leukemia Who Were Enrolled as Children on Clinical Trials EORTC-58741, EORTC-58831, EORTC-58832, or EORTC-58881 Between 1971 and 1998
RATIONALE: Studying medical records and collecting questionnaires from patients who were enrolled as children in clinical trials for acute lymphoblastic leukemia may help doctors learn about long-term effects of treatment and…
- Conditions
- Cancer Survivor, Leukemia, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT01298388
- Testing
- medical chart review, questionnaire administration, study of socioeconomic and demographic variables
- Volunteers
- 3,138 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Mantle Cell Lymphoma (MCL)
Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk Younger Untreated Mantle Cell Lymphoma
This is a single- arm, open-label, multicenter, phase II study to evaluate Acalabrutinib plus Rituximab for the treatment of elderly or low- to intermediate-risk younger untreated mantle cell lymphoma
- Trial name
- NCT06846489
- Testing
- Acalabrutinib, Rituximab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Leukemia, B-cell Leukemia
Phase 2 Fludarabine, Cytoxan and FCCAM <Alemtuzumab> in Untreated B-Cell Chronic Lymphocytic Leukemia
The primary objective of this study was to evaluate the safety and efficacy of the combination of fludarabine and cyclophosphamide in previously untreated CLL patients.
- Conditions
- Leukemia, B-cell Leukemia, Chronic Leukemia, Chronic Lymphocytic Leukemia (CLL)
- Trial name
- NCT00230282
- Testing
- Alemtuzumab, Fludarabine, Cytoxan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Steven E. Coutre
Mantle Cell Lymphoma
Clinical Trial of Ublituximab and Umbralisib With CHOP (U2-CHOP) Followed by U2 Maintenance (U2-CHOP-U2) in Previously Untreated Mantle Cell Lymphoma (MCL)
This is a single arm, multi-center, open label Phase Ib/II trial in adult patients with newly diagnosed Mantle Cell Lymphoma (MCL)(Stage II-IV).
- Trial name
- CHOP U2 (NCT04692155)
- Testing
- Ublituximab, Umbralisib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Bevacizumab to Treat Inflammatory Breast Cancer or Locally Advanced Breast Cancer
This study will evaluate the effectiveness of the drug bevacizumab, in combination with doxorubicin and docetaxel, in improving survival of patients with inflammatory breast cancer or locally advanced breast cancer.
- Trial name
- NCT00016549
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Pancreatic Cancer
Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas
This is an open-label, single arm, multi-center, Phase II trial to evaluate the progression free survival in patients with metastatic adenocarcinoma of the pancreas treated with a hedgehog inhibitor (GDC-0449) in combination with…
- Trial name
- NCT01088815
- Testing
- Gemcitabine, nab-Paclitaxel, GDC-0449
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Haemophilia A
Efficacy and Safety Evaluation Study of SCT800 in Previously Untreated Hemophilia A Patients.
This is an Open Label, Uncontrolled Study to Evaluate the the Safety and Efficacy of SCT800 for Prophylaxis Treatment in Severe Previously Untreated Hemophilia Patients.
- Trial name
- NCT07437404
- Testing
- SCT800 prophylaxis and treatment for bleeding events
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sinocelltech Ltd.
Neoplasms, Rectal
A Study of Dostarlimab in Participants With Untreated Locally Advanced Rectal Cancer in China
The main goal of this study is to evaluate the effect of dostarlimab monotherapy in Chinese participants with locally advanced Mismatch-repair deficient (dMMR)/ Microsatellite instability-high (MSI-H) rectal cancer who have…
- Trial name
- China AZUR-1 (NCT06640049)
- Testing
- Dostarlimab
- Where
- 9 sites in China
- Volunteers
- 23 people
- Sponsor
- GlaxoSmithKline
Effects of Chemotherapy, Safety Issues
Polatuzumab Vedotin and Zanubrutinib Plus R-CHP for Patients With Newly Diagnosed Untreated Non-GCB DLBCL
Aim of this study will evaluate the efficacy and safety of Polatuzumab Vedotin and Zanubrutinib in combination with R-CHP for newly diagnosed untreated Non-GCB DLBCL Patients with extranodal involvement.
- Trial name
- NCT06468943
- Testing
- Polatuzumab Vedotin, Zanubrutinib, Rituximab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Cytomegalovirus Infections
A Study on Spermatogenesis in Male Renal Transplant Recipients Receiving Valganciclovir (Valcyte®) Versus Untreated Matched Controls
This observational study will compare spermatogenesis in male adult renal transplant recipients receiving valganciclovir versus untreated matched controls.
- Trial name
- NCT01663740
- Testing
- Valganciclovir
- Where
- 19 sites in United States, Mexico
- Volunteers
- 59 people
- Sponsor
- Hoffmann-La Roche
Leukemia, Lymphoma
Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Leukemia
RATIONALE: Drugs used in chemotherapy, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00133991
- Testing
- Filgrastim, Rituximab, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Urothelial Carcinoma, HER2-expressing
A Study of RC48-ADC Combined With Toripalimab For First-line Treatment of Urothelial Carcinoma
This is a Phase 3, Open-Label, Multicenter, Randomised, Controlled Study designed to compare RC48-ADC in Combination With JS001 to Chemotherapy Alone in Previously Untreated HER2-Expressing Unresectable Locally Advanced or…
- Trial name
- NCT05302284
- Testing
- RC48-ADC, Toripalimab, Gemcitabine
- Where
- 2 sites in China
- Volunteers
- 452 people
- Sponsor
- RemeGen Co., Ltd.
Neoplasm, Prostate
Early Compared With Delayed Hormone Therapy in Treating Patients With Nonmetastatic Prostate Cancer
Objectives I. Compare, in a randomized Phase III multi-institutional setting, symptom-free survival time of patients with asymptomatic carcinoma of the prostate (T0-4, N0-2, M0) not suited for local curative treatment who are…
- Trial name
- NCT01819285
- Testing
- Immediate Orchiectomy or depot LHRH, Delayed Orchiectomy or depot LHRH
- Volunteers
- 985 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lymphoma, B-Cell
Rituximab+Standard CHOP vs Rituximab+Bi-weekly CHOP for Untreated Stage III/IV Low-grade B-cell Lymphoma (JCOG0203)
To establish standard therapy for patients with advanced-stage low grade B-cell lymphoma
- Trial name
- NCT00147121
- Testing
- Rituximab + Standard CHOP, Rituximab + Bi-weekly CHOP
- Where
- 45 sites in Japan
- Volunteers
- 300 people
- Sponsor
- Haruhiko Fukuda
Stage IV Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer
The purpose of this study is to find better treatment for lung cancer and to find out what effects the combined treatment of carboplatin and gemcitabine when given with or without dexamethasone have on cancer.
- Trial name
- NCT00247416
- Testing
- Gemcitabine, Dexamethasone, Carboplatin
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Susanne Arnold
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