Clinical trials: Upper Aerodigestive Tract Neoplasms
Hypopharyngeal Neoplasms, Laryngeal Neoplasms
Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive Tract
To assess the use of the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) in transoral surgeries in patients with benign and malignant lesions of the oral cavity and laryngopharynx.
- Conditions
- Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Head and Neck Cancers
- Trial name
- NCT00721539
- Testing
- da Vinci Surgical Robot Platform, Transoral Robotic Surgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Fibrosis, Breast Cancer
Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Radiotherapy for Breast Cancer or UADT (Upper Aerodigestive Tract) Cancer
FIBROTHERME is a comparative, controlled, randomized, multicenter and simple blinded (investigator) trial. The aim of this study is to evaluate the medical benefit in terms of quality of life on the dermatological sequelae of…
- Conditions
- Fibrosis, Breast Cancer, Head and Neck Cancer
- Trial name
- FIBROTHERME (NCT05874492)
- Testing
- Thermal cure with a primary dermatological indication
- Where
- 13 sites in France, Luxembourg
- Volunteers
- 110 people
- Sponsor
- Association Francaise pour la Recherche Thermale
Upper Aerodigestive Tract Cancer
Interventional Study Collecting Quantitative and Qualitative Data About Patient With Non Treated Cancer
This study aims to determine the impact of sociocognitive and emotional factors on the time of the initial consult
- Trial name
- DEREDIA (NCT01647477)
- Testing
- interview, questionnaires
- Where
- 6 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Oscar Lambret
Upper Aerodigestive Tract Neoplasms
Cancer of the Upper Aero-digestive Tract and Socio-professional Future
The aim of this study is to explore the main factors associated with the return to work of patients presenting an upper aero-digestive tract cancer.
- Trial name
- CARDEL (NCT01788878)
- Testing
- Questionnaires
- Where
- 8 sites in France
- Volunteers
- 46 people
- Sponsor
- Centre Oscar Lambret
Gastrostomy, Breakthrough Pain
Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy
Patients with Head \& Neck Squamous Cell Carcinoma often need a gastrostomy. It can be performed with a radiological approach. This procedure is usually not performed under general anesthesia, but local anesthesia is not…
- Conditions
- Gastrostomy, Breakthrough Pain, Upper Aerodigestive Tract Neoplasms
- Trial name
- ANTALGIP (NCT02869321)
- Testing
- Fentanyl, Morphine Sulfate, Gastrostomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Tobacco Use Disorder, Head and Neck Neoplasms
A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers
Smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival and other outcomes, but many patients have difficulty quitting after their diagnosis.
- Conditions
- Tobacco Use Disorder, Head and Neck Neoplasms, Thoracic Neoplasms, Radiation
- Trial name
- NCT02188563
- Testing
- Comprehensive smoking cessation intervention, Enhanced usual care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Oncology, Aerodigestive Tract Cancer
Impact of Adapted Aesthetic Onco in Patients With Upper Aerodigestive Tract Cancer During Their Management
Treatment for cancers of the pharyngolarynx is mutilating, with major consequences for patients' lives in terms of physical and functional after-effects.
- Conditions
- Oncology, Aerodigestive Tract Cancer, Suportive Care
- Trial name
- OEUVRE (NCT06959810)
- Testing
- Adapted Onco-Esthetics sessions
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Francois Baclesse
Carcinoma
Evaluation of the Oncoral® Test in Epidermoid Carcinomas of the Upper Aerodigestive Tract
This is a multicentric feasibility study aimed to evaluate the Oncoral® test. The study includes 2 steps. The first one aims to validate the algorithm defined at the time when the test was developed in patients with different…
- Trial name
- NCT01361100
- Testing
- Oncoral® test
- Where
- 8 sites in France
- Volunteers
- 485 people
- Sponsor
- Centre Leon Berard
Upper Aerodigestive Tract Neoplasms
Evaluation of Low-Level Laser Therapy Efficacy in Pain Management of Grade 2 Oral Mucositis Induced by Radiotherapy or Chemoradiotherapy: a Study in Patients With Upper Aerodigestive Tract Cancer
Prospective, monocentric, randomized phase II study evaluating Low-Level Laser Therapy (LLLT) as a treatment for the pain due to grade 2 oral mucositis in patients with upper aero-digestive tract cancer treated by radiotherapy or…
- Trial name
- ESMULLLAT (NCT03955224)
- Testing
- Basic Oral Care + active LLLT, Basic oral Care + inactive LLLT, Basic Oral Care
- Where
- France
- Sponsor
- Institut Claudius Regaud
Biopsy Confirmed Head and Neck Cancer and Tumors of the Chest
Oral Glutamine and Thoracic/Upper Aerodigestive Tumors Radiation Toxicity
PROTOCOL FOR PREVENTIVE ADMINISTRATION OF GLUTAMINE TO AVOID RADIATE SIDE EFFECTS IN PATIENTS UNDER RADIOTHERAPY IN THE CHEST AND HEAD \& NECK PURPOSE OF THE STUDY The purpose of the protocol is to study the acute and distant…
- Trial name
- NCT05054517
- Testing
- Glutamine
- Volunteers
- 72 people
- Sponsor
- National and Kapodistrian University of Athens
NK/T Cell Lymphoma
Dexamethasone, Azacytidine,Pegaspargase and Tislelizumab for NK/T Cell Lymphoma
The optimal first-line treatment for extra-nodal NK/T-cell lymphoma (ENKTL) has not been well-defined. This phase II study aimed to evaluate the efficacy and safety of Dexamethasone, azacytidine, Pegaspargase, Tislelizumab (DAPT)…
- Trial name
- NCT04899414
- Testing
- Dexamethasone, azacytidine, Pegaspargase, Tislelizumab
- Where
- 3 sites in China
- Volunteers
- 50 people
- Sponsor
- Peking University
Upper Aerodigestive Tract Neoplasms
Tracheal Exposure Without Tracheostomy Completion in Trans-oral Robotic Oncologic Surgery
Upper aerodigestive tract neoplasms surgery results in important trauma, including swelling (oedemas) that can lead to respiratory tract obstruction and death from suffocation.
- Trial name
- TRACH (NCT06857396)
- Testing
- PREPA-TRACH
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia
This study will assess the long-term safety and efficacy of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
- Trial name
- NCT06544798
- Testing
- AAV2-hAQP1
- Where
- 8 sites in United States, Canada
- Volunteers
- 276 people
- Sponsor
- MeiraGTx, LLC
Urothelial Carcinoma, Renal Cancer
Research of Double-positive Circulating Cells (Tumor Marker / CD45+) in Several Types of Metastatic Cancers
A prospective, proof-of-concept pilot study in patients with metastatic cancers (9 types of cancers are studied) treated at the IUCT-O or possibly in other institutions.
- Conditions
- Urothelial Carcinoma, Renal Cancer, Prostate Adenocarcinoma, Adenocarcinoma of Endometrium
- Trial name
- DP-PAN-CANCER (NCT06967961)
- Testing
- For each enrolled patient, the sample described below will be collected as specific intervention intended for research purposes:
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Institut Claudius Regaud
Recurrent Head and Neck Cancer
Transoral Robotic Surgery for rECurrent Tumours of the Upper Aerodigestive Tract
transoral Robotic surgery for rECurrent tumours of the Upper aerodigestive Tract
- Trial name
- RECUT (NCT04673929)
- Where
- 2 sites in United Kingdom
- Volunteers
- 278 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Esophageal Cancer, Head and Neck Cancer
Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer.
- Conditions
- Esophageal Cancer, Head and Neck Cancer, Lung Cancer, Precancerous Condition
- Trial name
- NCT00900419
- Testing
- immunohistochemistry staining method, laboratory biomarker analysis, sputum cytology
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Colorado, Denver
Fibrosis
Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
The pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. Hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of…
- Trial name
- ORT-OXI-2009 (NCT01822405)
- Testing
- pentoxifylline with tocopherol, pentoxifylline+tocopherol + Hyperbaric Oxygen Therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario de Canarias
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Upper Aerodigestive Tract Lesions, Neoplasms, Oropharyngeal
Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract
This study will compare TNFE-NBI and biopsy, with DRE and biopsy for the diagnostic evaluation and staging of patients with suspicious UADT lesions.
- Conditions
- Upper Aerodigestive Tract Lesions, Neoplasms, Oropharyngeal, Oropharyngeal Cancer, Neoplasms, Hypopharyngeal
- Trial name
- TNFE-NBI (NCT01175499)
- Testing
- Direct Rigid Endoscopy, Transnasal Flexible Endoscopy with Narrowband Imaging
- Sponsor
- University of California, San Francisco
Salivary Gland Cancers
Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14
SGCs are rare (less than 1% of head and neck cancers) and include many malignant histotypes. SGCs are treated mainly with surgery, followed by radiotherapy in selected cases.
- Trial name
- SGC-AX14 (NCT02857712)
- Testing
- Axitinib
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano