Clinical trials: Upper Extremity Function, open to volunteers
Stroke, Cerebrovascular Accident
Effects of tVNS and mCIMT in Chronic Stroke
Stroke is a leading cause of death and disability worldwide, resulting in significant physical and cognitive impairments. Arm weakness is most common after stroke and its treatment is recognized as an area of considerable need.
- Trial name
- NCT07272239
- Testing
- Transcutaneous Vagus Nerve Stimulation, Modified Constraint Induced Movement Therapy with Routine Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Stroke
Unilateral Versus Bilateral Task-specific Training on Motor Impairment, Upper Extremity Function, and Hand Dexterity in Post-Stroke Rehabilitation
This randomized clinical trial will examine upper limb rehabilitation in individuals recovering from stroke. The study will compare unilateral and bilateral task-oriented training approaches to determine their relative…
- Trial name
- NCT07523503
- Testing
- Unilateral task oriented training (UTOT) with baseline EMS, Bilateral task oriented training (BTOT) with baseline EMS
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Faisalabad
Distal Radius Fracture, Colles Fracture
Wrist Injury Strengthening Exercise (WISE) Versus Usual Care Advice for Improving Pain and Function
The goal of this clinical trial is to find out whether a therapist-guided exercise program helps people aged 50 and older recover better, in terms of pain and function, after a wrist fracture, compared to the usual care advice…
- Conditions
- Distal Radius Fracture, Colles Fracture, Wrist Fracture, Wrist Fractures
- Trial name
- WISE-DK (NCT07538323)
- Testing
- Supervised Exercise, Usual Care
- Where
- Denmark
- Volunteers
- 588 people
- Sponsor
- University of Aarhus
Chronic Stroke
Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke
Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke.
- Trial name
- NCT05615610
- Testing
- tSCS, tVNS, Control
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Palsy
Intensive Somatosensory Camp for Manual Function and Participation in Children With Unilateral Cerebral Palsy
This study will evaluate whether an intensive day camp that combines somatosensory and motor training for the affected upper limb improves hand function and participation in children with unilateral cerebral palsy more than an…
- Trial name
- CAMPUSENS (NCT07487857)
- Testing
- Somatosensory-Motor Intensive Camp, Motor-Only Intensive Camp
- Volunteers
- 26 people
- Sponsor
- University of Castilla-La Mancha
Cerebral Palsy
Strength Training Combined With Blood Flow Restriction and Cerebral Palsy
load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff.
- Trial name
- NCT07748052
- Testing
- strength training combined with blood flow restriction and designed physical therapy program, a specially designed physical therapy program
- Volunteers
- 26 people
- Sponsor
- Cairo University
Stroke, Mirror Therapy
A Pilot Study of Repetitive Transcranial Magnetic Stimulation
Stroke patients often have long-term upper limb dysfunction. Currently, there is still no specific clinical treatment for nerve damage.
- Conditions
- Stroke, Mirror Therapy, Transcranial Magnetic Stimulation
- Trial name
- NCT06482372
- Testing
- transcranial magnetic stimulation
- Volunteers
- 69 people
- Sponsor
- Cheng-Hsin General Hospital
Cerebral Palsy Spastic Hemiplegic, Functionnal Neurological Disorder
Virtual Reality-Augmented Constraint-Induced Movement Therapy Versus Conventional Constraint-Induced Therapy for Upper Limb Rehabilitation in Children With Unilateral Cerebral Palsy.
Cerebral palsy (CP) causes persistent motor and postural impairments that can limit children's functional independence and participation.
- Conditions
- Cerebral Palsy Spastic Hemiplegic, Functionnal Neurological Disorder, Upper Limb Functions, Virtual Reality Based Therapy
- Trial name
- NCT07853937
- Testing
- Rehabilitation intervention
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Faculty of Medicine, Sousse
Unilateral Cerebral Palsy
Wereables for Upper Limb Functionality in Hemiparesis
The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of…
- Trial name
- WeFun (NCT06872736)
- Testing
- WeFun-wearable activated, WeFun-wearable desactivated
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidade da Coruña
Hemiplegia, Stroke
Effects of Wearable Vibratory Devices on Arm Function in Subacute Stroke Patients
Hemiplegia, or paralysis of one side of the body, often results from stroke and severely limits arm function. Standard physiotherapy helps, but recovery is often slow.
- Trial name
- WEVIB-HEMI (NCT07641790)
- Testing
- Wearable Focal Muscle Vibrator
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Faisalabad
Stroke, Stroke, Acute
Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients
This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients.
- Trial name
- NCT07253870
- Testing
- Transcutaneous vagus nerve stimulation through auricular branch along with task specific exercises, Transcutaneous vagus nerve stimulation through cervical branch along with task specific exercises
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Spinal Cord Injuries, Peripheral Nerve Injuries
Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)
The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work.
- Trial name
- NCT06672458
- Testing
- MyndMove Short Term Therapy, Conventional Short Term Therapy, MyndMove Long Term Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Stroke, Upper Extremity Paresis
Virtual Reality Based Mirror Therapy
The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.
- Conditions
- Stroke, Upper Extremity Paresis, Upper Extremity Paralysis
- Trial name
- NCT06152328
- Testing
- Virtual reality applications based on mirror therapy, Conventional treatment, Mirror therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Abant Izzet Baysal University
Diabetes, Type I
A First-in-human Clinical Trial Using a Gene Therapy With Patient's Own Stem Cells to Treat Early Type 1 Diabetes
Purpose: The purpose of the trial is to assess the safety profile of the study treatment and to evaluate its efficacy in terms of improvement in key diabetes management parameters, including insulin requirements and β-cell…
- Trial name
- IMMUNOSTEM (NCT06938334)
- Testing
- Autologous CD34+ cell enriched population containing HSPCs transduced ex vivo using a LVV encoding the hPD-L1 DNA
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Altheia Science
Chronic Stroke Patient
TELE-REHABILITATION VERSUS CLINIC-BASED MODIFIED CONSTRAINT-INDUCED MOVEMENT THERAPY FOR UPPER LIMB FUNCTION IN CHRONIC STROKE PATIENTS
Stroke commonly results in persistent upper limb impairment that limits functional independence and participation in daily activities.
- Trial name
- TELE-mCIMT (NCT07720609)
- Testing
- Tele-Rehabilitation-Based Modified Constraint-Induced Movement Therapy, Clinic-Based Modified Constraint-Induced Movement Therapy
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Kainat Tariq
Indicated for Pelvic Radiotherapy, Vaginal Rehabilitation, and Alleviation of Late Toxic Reactions in the Vagina
Vaginal Function Exercisers and Vaginal Dilation Irrigation Drug Administration Tubes Are Used for Vaginal Rehabilitation Therapy in Pelvic Radiotherapy
Gynecological pelvic tumors primarily include ovarian cancer, cervical cancer, and endometrial cancer. Radiotherapy (RT) is one of the key treatment modalities for gynecological tumors.
- Trial name
- Exerciser (NCT07473271)
- Testing
- Vaginal exerciser and vaginal dilator with irrigation tube
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Peking Union Medical College Hospital
Multiple Sclerosis (MS) - Relapsing-remitting, Upper Extremity Dysfunction
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people…
- Trial name
- NCT07376772
- Testing
- wearable focal vibration therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Stroke, Hemiplegia
The Effect of Modified Constraint Induced Movement Therapy on Upper Extremity Function in Stroke Rehabilitation
The purpose of the study is to determine the effect of Modified Constraint-Induced Movement Therapy and trunk restraint contrasted with conventional physical therapy treatment on improving upper extremity function, balance, and…
- Conditions
- Stroke, Hemiplegia, Chronic Stroke Patients
- Trial name
- mCIMT (NCT06692569)
- Testing
- Conventional Physical Therapy, Modified Constraint Induced Movement Therapy
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- University of Jazan
Repetitive Transcranial Magnetic Stimulation, Stroke
Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological
To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Stroke, Functional MRI
- Trial name
- NCT06799312
- Testing
- Ipsilesional high frequency rTMS combined with physiotherapy, Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Assiut University
Stroke
Virtual Reality's Impact on Upper Limb Function in Post-stroke Patients
Stroke rank second among the top causes of death, affecting millions of people in the worldwide. Approximately 70-80% survivors of stroke could experience various levels of upper limb motor impairments, which seriously affects…
- Trial name
- NCT06881680
- Testing
- virtual reality (VR) head mounted display
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University