Clinical trials: Upper Extremity Functions
Alzheimer Disease
Transmagnetic Stimulation Pilot in Early Stage Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative condition affecting 6.2 million individuals in the United States, resulting in an annual cost of care of $305 billion.
- Trial name
- NCT05292222
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Stroke
Ipsihand Device Use in Stroke Patients to Assess Functional Motor Outcomes
This study aims to evaluate the impact of the Neurolutions Upper Extremity Rehabilitation System, known as IpsiHand, on improving functional motor control for post-stroke patients with hemiparesis.
- Trial name
- NCT04338971
- Testing
- IpsiHand Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Neurolutions, Inc.
Cerebrovascular Stroke
Fast Arm Motor Skill Training in Chronic Stroke Survivors
Every year, almost 800,000 people experience a stroke in the United States, which lead to upper-limb impairments, making recovery of motor function a priority in stroke rehabilitation.
- Trial name
- FAST (NCT05013762)
- Testing
- Fast intervention, Active Monitoring
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Southern California
Stroke, Muscle Spasticity
Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function
The purpose of this study is to evaluate the safety of injections of botulinum toxin Type A in patients with reduced lung function and focal upper limb poststroke spasticity
- Conditions
- Stroke, Muscle Spasticity, Motor Neuron Disease
- Trial name
- NCT00076687
- Testing
- botulinum toxin Type A, saline
- Where
- 4 sites in United States, Czechia and 2 more
- Volunteers
- 155 people
- Sponsor
- Allergan
Stroke, Physical Disability
Neuroplasticity With Daily Use of a Sensorimotor Priming Vibration System to Improve Hand Function After Stroke
More than 4 million stroke survivors in the U.S. suffer from post-stroke sensorimotor hand disability, which is typically permanent and difficult to treat.
- Trial name
- NCT04026399
- Testing
- peripheral vibration stimulation, therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Mitral Stenosis With Insufficiency, Functional Mitral Regurgitation
AVJ-514 Japan Trial
The objective of the study is to confirm the reproducibility of the evidence of safety and efficacy of AVJ-514 System technology in Japanese subjects who have been deemed difficult for mitral valve surgery by the local site heart…
- Conditions
- Mitral Stenosis With Insufficiency, Functional Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence
- Trial name
- NCT02520310
- Testing
- AVJ-514
- Where
- 6 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Distal Radius Fracture
Motor Imagery in Rehabilitation After a Distal Radius Fracture
The aim of this study is to determine whether motor imagery training during the immobilisation period in patients with a distal radius fracture, results in an improved functional outcome compared to patients who do not perform…
- Trial name
- MIDRF (NCT01921062)
- Testing
- Motor imagery
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- University Medical Center Groningen
Non-functioning Pituitary Adenoma
Evaluate the Efficacy and Safety of Pasireotide LAR (Long Acting Release) on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma.
This study assessed pasireotide LAR efficacy on patients with non-functioning pituitary adenomas concerning tumor growth.
- Trial name
- Passion I (NCT01283542)
- Testing
- Pasireotide LAR
- Where
- 7 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 2, Renal Insufficiency
An Efficacy, Safety, and Tolerability Study of Canagliflozin in Patients With Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in patients with type 2 diabetes mellitus who have reduced kidney function.
- Trial name
- NCT01064414
- Testing
- Canagliflozin
- Where
- 106 sites in United States, Australia and 16 more
- Volunteers
- 272 people
- Sponsor
- Janssen Research & Development, LLC
Stroke, Impaired Upper Extremity Function
Extension of the MIME Robotic System for Stroke Rehabilitation
The goal of this project is to develop and test a new robotic system to accommodate practice of tasks requiring reach, grasp and release of objects.
- Trial name
- NCT00995774
- Testing
- robotic therapy, conventional functional training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Lung Transplantation
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
This trial evaluated the efficacy of an everolimus-based quadruple low immunosuppressive regimen versus a standard immunosuppressive regimen concerning kidney function in lung transplant recipients.
- Trial name
- 4EVERLUNG (NCT01404325)
- Testing
- standard therapy, Everolimus
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplantation (Status Post)
Efficacy, Safety, Tolerability and Pharmacokinetic (PK) Study of GSK1070806 for the Prevention of Delayed Graft Function (DGF) in Adult Subjects After Renal Transplantation
This is a phase 2 study to evaluate the efficacy, safety, tolerability and pharmacokinetics of GSK1070806 in subjects undergoing renal transplantation.
- Trial name
- NCT02723786
- Testing
- GSK1070806, 1) basiliximab 2) mycophenolate mofetil (MMF) OR azathioprine 3) tacrolimus 4) corticosteroids
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 7 people
- Sponsor
- GlaxoSmithKline
Duchenne Muscular Dystrophy
Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD
This study is a longitudinal, randomized control trial evaluating the use of two commercially available dynamic arm support devices (1) Armon Ayura-Kinova and 2) JAECO WREX) to promote participation in activities of daily living…
- Trial name
- NCT03531788
- Testing
- Armon Ayura (Kinova), JAECO Wrex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roxanna Marie Bendixen
Stroke
Effects of Home-based Program in Improving Sitting Balance and Upper Limb Functions in Patients With Stroke
The investigators hypothesize that application of electrical stimulation would augment the effects of exercises in patients with stroke.
- Trial name
- NCT01200030
- Testing
- electrical stimulation with exercises
- Where
- Hong Kong
- Volunteers
- 37 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Brain Diseases
Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke.
- Conditions
- Stroke, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- NCT04512690
- Testing
- Epidural electrical stimulation (EES) of the cervical spinal cord
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lee Fisher, PhD
Stroke
Effectiveness of Intelligent Rehabilitation Robot Training System Combined With Repetitive Facilitative Exercise on Upper Limb Motor Function After Stroke: a Randomized Control Trial.
The goal of this clinical trial is to learn if intelligent rehabilitation robot training system combined with repetitive facilitative exercise (RFE) work to treat stroke in adults.
- Trial name
- NCT06435624
- Testing
- intelligent robotic-assisted training, repetitive facilitative exercise, conventional therapy
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Nanjing Mingzhou Rehabilitation Hospital
Spinal Muscular Atrophy
Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)
To evaluate the safety, tolerability and efficacy of intravenous administration of OAV101 (AVXS-101) in patients with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene weighing ≥…
- Trial name
- SMART (NCT04851873)
- Testing
- OAV101
- Where
- 13 sites in United States, Australia and 7 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
A Target Occupancy Study With Ritlecitinib.
This is a phase 1, open label, two-arm study to assess target occupancy and functional inhibition of JAK3 and TEC kinases by Ritlecitinib in healthy adult participants
- Trial name
- NCT05128058
- Testing
- Ritlecitinib 50 mg, Ritlecitinib 200 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease (COPD)
An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.
This is a research study to evaluate the efficacy and safety of the investigational drug Mitiperstat (AZD4831) in adult patients with chronic obstructive pulmonary disease.
- Trial name
- CRESCENDO (NCT05492877)
- Testing
- Mitiperstat (AZD4831)
- Where
- 101 sites in United States, Argentina and 12 more
- Volunteers
- 381 people
- Sponsor
- AstraZeneca