Clinical trials: Upper Gastrointestinal Disease,Ulcers
Dyspepsia, Gastroesophageal Refluxdisease
Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice
The primary purpose of the study is to determine the effect of esomeprazole compared to placebo in patients from general practice who have previously been treated with proton-pump-inhibitors (PPI) and who have no upper endoscopic…
- Conditions
- Dyspepsia, Gastroesophageal Refluxdisease, Ulcer
- Trial name
- NCT00363701
- Testing
- esomeprazole
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Bleeding Peptic Ulcer, Active Bleeding
Urgent vs. Early Endoscopy in High Risk Patients With Upper Gastrointestinal Bleeding (UGIB)
Acute upper gastrointestinal bleeding (UGIB) is one of the commonest medical emergencies. The condition accounts for 150 per 100,000 populations. A National United Kingdom reported a crude overall mortality rate of 10%.
- Conditions
- Bleeding Peptic Ulcer, Active Bleeding, Gastrointestinal Bleeding
- Trial name
- NCT01675856
- Testing
- Urgent endoscopy, Early endoscopy
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Chinese University of Hong Kong
Gastritis, Peptic Ulcer
H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department
This pilot study aims to estimate the prevalence of Helicobacter pylori (H. pylori) colonization in patients presenting with non-specific abdominal pain (NSAP) in an urban academic emergency department (ED) located in Washington…
- Conditions
- Gastritis, Peptic Ulcer, Peptic Ulcer Perforation, Stomach Ulcer
- Trial name
- NCT01376414
- Testing
- Urea Breath Test (UBT) for H. pylori infection
- Where
- 2 sites in United States
- Volunteers
- 212 people
- Sponsor
- George Washington University
Duodenal Ulcer Bleeding
Prophylactic Injection Therapy Reduces Recurrent Bleeding In Forrest Type IIb Duodenal Ulcers
The purpose of this study is to determine whether prophylactic injection therapy reduces recurrent bleeding rate for duodenal ulcers which has the endoscopic stigmata of recent bleeding.
- Trial name
- NCT01471496
- Testing
- prophylactic injection therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Peptic Ulcer Hemorrhage
ClearEndoclip Versus EZ Clip for Upper Gastrointestinal Ulcer Bleeding
We are going to conduct a comparative study to analyze the clinical effectiveness and user convenience of EZ clips that have been used in upper gastrointestinal ulcer bleeding and newly developed clip (ClearEndoclip, FineMedix…
- Trial name
- NCT04536428
- Testing
- Endoscopic hemostasis with clip
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Ajou University School of Medicine
Upper Gastrointestinal Disorder
Upper Endoscopy in Ulcerative Colitis Patients in Assiut University
Aim of study: Primary Outcomes: Patients with ulcerative colitis-associated upper gas- trointestinal inflammation may require specific treat- ment for the gastroduodenal lesions.
- Trial name
- NCT06092593
- Testing
- Upper endoscopy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Upper Gastrointestinal Disease,Ulcers
Stress Response Using Thin and Standard Size Endoscopy.
Sixty patients scheduled for upper diagnostic gastroscopy were randomised after written informed consent into three groups. 1. transnasal gastroscopy with thin endoscope 2. transoral with thin endoscope 3.
- Trial name
- NCT00273130
- Testing
- transnasal endoscopy, transoral thin endoscopy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Upper Gastrointestinal Hemorrhage
Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's…
- Trial name
- NCT03065465
- Testing
- Over-the-scope hemoclipping device, Standard endoscopic treatment
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CURE Digestive Diseases Research Center
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Registry for Upper Gastrointestinal Bleeding
This project aims to evaluate the data on all patients undergoing endoscopic therapy for upper gastrointestinal bleeding.
- Trial name
- NCT04211194
- Testing
- Upper GI Endoscopy
- Where
- United States
- Volunteers
- 2,999 people
- Sponsor
- AdventHealth
Peptic Ulcer Hemorrhage
The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding
The purpose of this study is to assess whether adherence to NVUGIB guidelines is improved with implementation of a national, tailored multifaceted intervention.
- Trial name
- REASON-II (NCT00840008)
- Testing
- Educational intervention
- Volunteers
- 3,157 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Gastroesophageal Reflux Disease, Gastritis
Analysis of Biopsies From the Upper Gastrointestinal Tract
Multicenter study to correlate histological findings in the upper gastrointestinal tract with endoscopic and clinical data.
- Trial name
- histoGERD (NCT01576289)
- Testing
- Histological analysis
- Where
- Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Peptic Ulcer
Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy
To evaluate if intravenous PPI infusion, when administered prior to endoscopy, hastens resolution of bleeding stigmata and thereby facilitates endoscopic examinations and reduces the need for endoscopic treatment.
- Trial name
- NCT00164866
- Testing
- Omeprazole
- Where
- China
- Volunteers
- 638 people
- Sponsor
- Chinese University of Hong Kong
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer
European Survey of Non-Variceal Upper Gastro Intestinal Bleeding (NVUGIB)
The aim of this study is to assess the current management strategies in a pan-European "real-life" setting to uncover the unmet need in this area: non-variceal gastrointestinal bleedings.
- Conditions
- Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer, Gastrointestinal Hemorrhage
- Trial name
- ENERGIB (NCT00797641)
- Where
- 97 sites in Belgium, Greece and 5 more
- Volunteers
- 2,500 people
- Sponsor
- AstraZeneca
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.