Clinical trials: Upper Gastrointestinal Disorders
Abdominal Pain, Irritable Bowel Syndrome
Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency
This is a 3-year prospective study too identify the role of exocrine pancreatic insufficiency in patients with abdominal pain who are undergoing upper endoscopy.
- Trial name
- NCT04231279
- Testing
- synthetic human secretin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Orlando Health, Inc.
Intubation;Difficult, Gastrointestinal Bleeding
Evaluation of Prophylactic Endotracheal Intubation
Upper gastrointestinal (GI) bleeding is defined as patients who either presented with hematemesis or presented with melena along with evidence of hemodynamic compromise.
- Trial name
- NCT03716466
- Testing
- Endotracheal intubation, No airway intervention
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Texas Southwestern Medical Center
Gastroesophageal Reflux
ASTERIX: Low Dose ASA and Nexium
The purpose of the study is to evaluate the effect of esomeprazole 20 mg od versus placebo for the prevention of gastric and/or duodenal ulcers in patients taking low-dose ASA.
- Trial name
- NCT00251966
- Testing
- Esomeprazole
- Where
- 94 sites in Australia, Bulgaria and 9 more
- Volunteers
- 960 people
- Sponsor
- AstraZeneca
Hilar Cholangiocarcinoma, Bile Duct Injury
Superior Bilioenteric Anastomosis by Magnetic Compressive Technique
The purpose of this study is to determine whether the magnetic compressive anastomosis has a better outcomes than traditional manual anastomosis on superior bilioenteric anastomosis.
- Conditions
- Hilar Cholangiocarcinoma, Bile Duct Injury, Choledochal Cyst, Biliary Calculi
- Trial name
- CTREG (NCT02801500)
- Testing
- Magnetic Compressive Anastomosis, Manual Anastomosis
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Liver Cirrhosis, Upper Gastrointestinal Bleeding
Prophylactic Antibiotics in Prevention of Spontaneous Bacterial Peritonitis in Compensated Liver Cirrhosis
timely short-term antibiotic prophylaxis is an essential step in the management of these patients . Prophylaxis must be instituted as early as variceal hemorrhage is suspected, and timely administration has been associated with a…
- Trial name
- NCT04711122
- Testing
- Third generation cephalosporin antibiotics
- Volunteers
- 80 people
- Sponsor
- Assiut University
Peptic Ulcer Hemorrhage
Helicobacter Pylori Empiric Treatment in Ulcer Bleeding
The goal of the study is to compare the effectiveness of empirical Helicobacter pylori treatment compared with treatment depending on diagnostic tests for Helicobacter pylori in patients with Upper gastrointestinal bleeding due…
- Trial name
- HETUB (NCT00687336)
- Testing
- Empirical Hp eradication, Eradication treatment guided by a positive test
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Hospital de Sabadell
Perforated Peptic Ulcer
The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction
This is a multicenter trial comparing laparoscopic correction of a perforated peptic ulcer with the open technique by upper laparotomy.
- Trial name
- LAMA (NCT00745667)
- Testing
- laparoscopic surgery, Upper laparotomy
- Where
- Netherlands
- Volunteers
- 109 people
- Sponsor
- Erasme University Hospital
Upper Gastrointestinal Bleeding (UGIB)
Evaluation of ClearPlasma in Patients With Upper Gastrointestinal Bleeding.
Upper gastrointestinal hemorrhage (UGIH) is one of the most common gastrointestinal emergencies, and is associated with significant morbidity and mortality. Plas-Free aims to evaluate ClearPlasma safety in patients with UGIH.
- Trial name
- CLearPlasma (NCT06761430)
- Testing
- ClearPlasma
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- PlasFree Ltd.
Intestinal Anastomotic Leak, Intestinal Perforations
Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations
The purpose of this registry is to collect data on the clinical use of endoluminal vacuum (E-Vac) therapy to treat both upper and lower intestinal leaks and perforations.
- Trial name
- NCT02477930
- Testing
- No interventions are done
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Chronic Liver Disease, Inflammatory Bowel Diseases
Impact of Counselling and Visual Aid on Anxiety in Endoscopic Patients
A single blind randomized controlled trial was conducted to compare the effect of counselling and visual aid on the anxiety levels in patients undergoing endoscopy and to investigate the superiority of visual aid over…
- Trial name
- NCT05241158
- Testing
- Counselling with visual aid, Counselling
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- King Edward Medical University
Peritoneal Carcinomatosis, Gastrointestinal Cancer
Cytoreductive Surgery(CRS) Plus Hyperthermic Intraoperative Peritoneal Chemotherapy(HIPC) With Cisplatin to Treat Peritoneal Carcinomatosis From Upper Gastrointestinal Cancer
The majority of patients with upper gastrointestinal cancer, such as gastric, biliary, or pancreatic carcinoma, present with metastatic disease, and have an extremely poor survival, irrespective the type of treatment modality.
- Trial name
- NCT01116791
- Testing
- Cytoreductive Surgery (CRS) plus Hyperthermic Intraoperative Peritoneal Chemotherapy with Cisplatin (HIPC)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Baki Topal
Upper Gastrointestinal Disease,Ulcers
Stress Response Using Thin and Standard Size Endoscopy.
Sixty patients scheduled for upper diagnostic gastroscopy were randomised after written informed consent into three groups. 1. transnasal gastroscopy with thin endoscope 2. transoral with thin endoscope 3.
- Trial name
- NCT00273130
- Testing
- transnasal endoscopy, transoral thin endoscopy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Peptic Ulcer Hemorrhage
ClearEndoclip Versus EZ Clip for Upper Gastrointestinal Ulcer Bleeding
We are going to conduct a comparative study to analyze the clinical effectiveness and user convenience of EZ clips that have been used in upper gastrointestinal ulcer bleeding and newly developed clip (ClearEndoclip, FineMedix…
- Trial name
- NCT04536428
- Testing
- Endoscopic hemostasis with clip
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Ajou University School of Medicine
Esophageal and Gastric Varices
Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
The purpose of this study is to develop a grading system for esophageal varices using capsule endoscopy in patients with portal hypertension and cirrhosis.
- Trial name
- NCT00475592
- Testing
- Esophageal Capsule Endoscopy, Upper Gastrointestinal Endoscopy
- Where
- United States
- Sponsor
- Johns Hopkins University
Dysphagia, GERD
Does Use of Topical Lidocaine in EGD Reduce Amount of IV Midazolam and Fentanyl Required and Shorten Recovery Time
Patients will be randomized to a placebo or study group who will receive topical lidocaine prior to EGD. Amount of medication used, recovery time, patient/endoscopist satisfaction will then be assessed.
- Conditions
- Dysphagia, GERD, Abdominal Pain
- Trial name
- NCT02620501
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Brooke Army Medical Center
Esophagogastroduodenoscopy, Simethicone
Premedication With N-acetylcysteine and Simethicone to Improve Mucosal Visualization in Elective Upper Endoscopy
The goal of this randomized, double-blind, placebo-controlled clinical trial is to assess whether the combination of N-acetylcysteine and simethicone improves mucosal visibility during upper gastrointestinal endoscopy in adults…
- Conditions
- Esophagogastroduodenoscopy, Simethicone, N-Acetylcysteine, Premedication
- Trial name
- NACSIMET (NCT07245095)
- Testing
- Premedication with n-acetylcysteine, Premedication with simethicone
- Where
- 2 sites in Mexico
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexicali
Laryngopharyngeal Reflux
Reflux Band in Laryngopharyngeal Reflux
This 12 week biomarker targeted double blind randomized controlled trial (RCT) will enroll subjects with salivary pepsin positive laryngopharyngeal reflux (LPR) to assess efficacy of the external upper esophageal sphincter (UES)…
- Trial name
- NCT04827355
- Testing
- External Upper Esophageal Sphincter (UES) Compression Device
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Squamous Cell Carcinoma, Breath Test
Early Diagnosis of Upper Digestive Tract Disease
Upper digestive tract cancer (UDC) is a major disease burden worldwide encompassing all cancers involving the digestive tract (from oral cavity to duodenum).
- Conditions
- Squamous Cell Carcinoma, Breath Test, Digestive System Disease, Diagnose Disease
- Trial name
- E-DIGEST (NCT04475952)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Embolization, Hemorrhoids
SRAE With Embospheres for Hemorrhoids.
In this study , safety and efficacy of superior rectal artery embolization with embospheres will be researched prospectively.
- Trial name
- NCT03740321
- Testing
- Embolization with tri-acryl gelatin (Embosphere) particles
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Eskisehir Osmangazi University
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH