Clinical trials: Upper Gastrointestinal Disorders
Obesity
Comparison of the Microbial Composition in Lean and Obese Subjects
Rationale: The microbial composition in the small intestine (SI) differs largely from the composition in feces. Many physiological processes related to health, such as immunoregulation and metabolic programming, mainly take place…
- Trial name
- DUPLO (NCT03075228)
- Testing
- IntelliCap
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Biliary Disease Tract, Biliary Stenosis
Supra-papillary Versus Trans-papillary Biliary Stenting in Malignant Peri-hilar Stenosis
This is a randomized controlled trial comparing patients with obstructive jaundice due to malignancies of the perihilar area of bile ducts and undergoing both preoperative and palliative biliary drainage.
- Conditions
- Biliary Disease Tract, Biliary Stenosis, Biliary Stents
- Trial name
- SupraBilS (NCT07325877)
- Testing
- ERCP with suprapapillary stent placement, ERCP with transpapillary stent placement
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Gastroesophageal Reflux
Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort
This study evaluates the treatment of newly diagnosed gastro-esophageal reflux disease in a Danish national cohort, comparing medical and surgical treatment.
- Trial name
- NCT03524781
- Where
- Denmark
- Volunteers
- 36,292 people
- Sponsor
- University of Southern Denmark
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection
Endoscopic Resection of Gastrointestinal Neoplasms
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare…
- Conditions
- Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms
- Trial name
- NCT04780256
- Testing
- Endoscopic resection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
Cystic Fibrosis, Muscle Strength
Muscle Strength, Functional Capacity, Respiratory Function and Quality Of Life In Cystic Fibrosis Patients
This study was designed to investigate the relationship between upper extremity muscle strength and endurance, functional capacity, and quality of life child and adolescent with cystic fibrosis
- Conditions
- Cystic Fibrosis, Muscle Strength, Pulmonary Function, Functional Capacity
- Trial name
- NCT04734743
- Testing
- cystic fibrosis
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cagtay Maden
EGD, Covid19
Aerosol Particle From EGD in Patients With and Without Head Box in COVID-19 Era
According to preexisting data, it has revealed the fundamental role that aerosols play in the transmission of the COVID-19 virus.
- Conditions
- EGD, Covid19, Aerosol Disease, Head Box
- Trial name
- NCT04981535
- Testing
- Head box during upper gastrointestinal endoscopy
- Where
- Thailand
- Volunteers
- 190 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Cancer of Gastrointestinal Tract
Personalized Immunotherapy in Adults With Upper Gastrointestinal Tract Cancers
The purpose of this study is to determine if it is possible to make and safely administer a 'personalized' cancer vaccine for people diagnosed with an upper gastrointestinal tract cancer.
- Trial name
- NCT05153304
- Testing
- personalized vaccine, Nivolumab
- Where
- United States
- Sponsor
- University of California, San Diego
Hemorrhoids
Trans-radial Superior Rectal Artery Embolisation for Haemorrhoids
Endovascular embolisation is already a common procedure for bleeding haemorrhoids in the acute setting, where surgical options are not possible or have been exhausted.
- Trial name
- NCT06175325
- Testing
- Trans-radial embolisation of haemorrhoids
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Pancreatic Adenocarcinoma
The DISSECT Study: Effect of Peri-aDventItial SMA diSsECtion on Margin sTatus During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
There is a high rate of R1 resection following patients undergoing pancreaticoduodenectomy for pancreatic cancer. The most commonly positive margin is the SMA.
- Trial name
- NCT04902352
- Testing
- No Periadventitial dissection of the SMA, Periadventitial dissection of the SMA
- Where
- United Kingdom
- Volunteers
- 102 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Esophageal Neoplasms, Cancer of Esophagus
Mayo Clinic Upper Digestive Disease Survey
The Mayo Clinic Conduit Report Card Questionnaires have been created in order to have a consistent evaluation tools for patients undergoing esophageal reconstruction or treatment or patients that are experiencing an upper…
- Conditions
- Esophageal Neoplasms, Cancer of Esophagus, Cancer of the Esophagus, Esophageal Cancer
- Trial name
- UDD (NCT02530983)
- Testing
- Mayo Clinic Upper Digestive Disease Survey on Paper, Upper Digestive Disease (UDD Monitor) App
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Dyspepsia
The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.
"Functional dyspepsia" has been defined loosely as "pain or discomfort centered in the upper abdomen." The symptoms can also include fullness, early satiety, bloating, belching, nausea, retching and vomiting.
- Trial name
- NCT00303264
- Testing
- dexloxiglumide, Nexium (esomeprazole)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Forest Laboratories
Hemorrhoids, Embolization, Therapeutic
Transarterial Coil Embolization of the Superior Rectal Arteries for Treatment of Stage II Hemorrhoids
This study will evaluate short , mid and long term efficacy of transarterial coil embolization of the superior rectal arteries (Emborrhoid techinque) for treatment the hemorrhoidal disease.
- Trial name
- NCT03805087
- Testing
- Transarterial coil embolization
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Hepatitis E
Safety and Immunogenicity Study of Thiomersal-free Hepatitis E Vaccine in People Ages 16 Years and Above
The purpose of this study is to evaluate the safety and non-inferior immunogenicity of thiomersal-free Recombinant Hepatitis E Vaccine (Escherichia Coli) compared with licensed Recombinant Hepatitis E Vaccine (Escherichia Coli)…
- Trial name
- NCT06564116
- Testing
- Thiomersal-free Recombinant Hepatitis E Vaccine (Escherichia Coli), Recombinant Hepatitis E Vaccine (Escherichia Coli)
- Where
- China
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
Transfer Dysphagia, Oropharyngeal Dysphagia
Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia
Dysphagia in patients with stroke, multiple sclerosis, parkinsonism or dystonia can occur due to relative hypertonia of the cricopharyngeus muscle. In the resting state, muscle is contracted and relaxes only during deglutition.
- Conditions
- Transfer Dysphagia, Oropharyngeal Dysphagia, Cricopharyngeus Muscle Dysfunction
- Trial name
- NCT04695600
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Gastrointestinal Cancer
The Laparotomy Study
The depth of neuromuscular blockade (NMB) during surgery may cause a clinical dilemma between optimal surgical conditions and the risk of postoperative residual blockade.
- Trial name
- NCT02140593
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- Herlev Hospital
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Oesophageal Cancer, Gastric Cancer
Upper GI Serial Tumour Biopsies
This is a prospective translational research study in which tumour samples, blood samples and other biospecimens will be requested from patients with locally advanced or metastatic malignant oesophageal and gastric carcinoma.
- Trial name
- NCT05233007
- Testing
- Minor endoscopic biopsy
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- The Christie NHS Foundation Trust
Upper Gastrointestinal Bleeding
Side Effects of Transesophageal Echocardiography
Transesophageal echocardiography is commonly used during cardiac surgery. Complications of transesophageal echocardiography are rare (1,2%), but are often underestimated and can lead to unrecognized blood loss and site of…
- Trial name
- NCT03432559
- Testing
- endoscopy
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Cystic Fibrosis, Lungtransplantation
Upper and Lower Airway Colonization in Cystic Fibrosis Patients After Lung Transplantation
A hot topic in lung transplantation is the treatment of persisting sinus disease/colonization in CF patients to prevent descending graft colonization and chronic allograft dysfunction.
- Conditions
- Cystic Fibrosis, Lungtransplantation, Paranasal Sinus Diseases
- Trial name
- NCT02591524
- Testing
- Bronchoalveolar and Nasal Lavage
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Hannover Medical School