Clinical trials: Upper Gastrointestinal Disorders
Upper Gastrointestinal Bleeding
Non-warfarin Oral AntiCoagulant Resumption After Gastrointestinal Bleeding in Atrial Fibrillation Patients
Current clinical society guidelines and statements are non-specific and relatively open-ended regarding the optimal timing to restart non-warfarin oral anticoagulant (NOAC) after gastrointestinal bleeding (GIB) in patients with…
- Trial name
- NOAC-GAP (NCT03785080)
- Testing
- restart NOAC very early, restart NOAC early
- Where
- 3 sites in Australia, Hong Kong and 1 more
- Volunteers
- 552 people
- Sponsor
- Chinese University of Hong Kong
Sigmoid Cancer
A Prospective, Randomized, Open, Parallel-controlled, Superior-efficacy Clinical Study of Radical Sigmoidectomy for Sigmoid Cancer Versus Radical Sigmoidectomy Combined with Indocyanine Green Fluorescence Imaging Lymphatic Tracing Dissection in the Treatment of Sigmoid Cancer
he purpose of this study is to explore the clinical outcomes of Indocyanine Green Tracer using in laparoscopic radical sigmoidectomy for sigmoid adenocarcinoma (cT2-T4a N0 M0，T1-T4a N+ M0).
- Trial name
- NCT06396806
- Testing
- indocyanine green fluorescence imaging lymphatic tracing
- Where
- China
- Volunteers
- 1,072 people
- Sponsor
- Sun Yat-sen University
Gastrointestinal Hemorrhage, Hematemesis
Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopy in Patients With Upper Gastrointestinal Bleeding
The researchers will investigate whether erythromycin infusion is better than gastric lavage prior to emergency endoscopy to improve the quality of examination in patients with upper gastrointestinal bleeding.
- Trial name
- NCT01716572
- Testing
- Erythromycin, gastric lavage
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Hospital Universitari de Bellvitge
Colorectal Cancer, Colorectal Surgery
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Effective postoperative pain management is essential for enhanced recovery after laparoscopic colorectal surgery. This randomized, controlled, double-blind trial will compare conventional postoperative analgesia (intravenous…
- Conditions
- Colorectal Cancer, Colorectal Surgery, Anesthesia, Autonomic Nerve Block
- Trial name
- BAPTAP (NCT07388953)
- Testing
- Minimally Invasive Left-Sided Colorectal Resection, BAPTAP (Peripheral Autonomic Blockade + TAP Block), Trocar/Incision Infiltration
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Pancreatic and Periampullary Tumors
Pancreatoduodenectomy in Pancreatic and Periampullary Tumors
Background: Recently it has been observed in pancreatic cancer that after apparently complete surgical resection, histological examination of the surgical specimen according to a standard protocol reveals tumor infiltration of…
- Trial name
- DUOPAN-EPAM (NCT02803814)
- Testing
- Superior mesenteric artery approach for pancreatoduodenectomy, Classic approach for pancreatoduodenectomy
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Other Specified Disorders of Esophagus, Stomach or Duodenum
EUS-FNA Versus KHB in Diagnostics of Upper Gastrointestinal Submucosal Tumors
Upper Gastrointestinal Submucosal Tumors are tumors arising from subepithelial layers of esophageal, gastric or duodenal wall. They usually have an intact mucosa lining on the inner surface.
- Trial name
- NCT02025244
- Testing
- Key Hole Biopsy ( KHB), EUS-FNA
- Where
- 2 sites in Czechia
- Volunteers
- 52 people
- Sponsor
- Vitkovice Hospital
Peptic Esophagitis, Peptic Ulcer
Diagnostic Value of Fecal Calprotectin in Disorders of the Upper Gastrointestinal Tract
Fecal calprotectin is a very sensitive non-invasive inflammation marker in the detection of inflammatory bowel disease and, to a lesser degree, has also proven to be useful in adenomatous polyps, neoplasias, and infectious…
- Conditions
- Peptic Esophagitis, Peptic Ulcer, Functional Dyspepsia, Irritable Bowel Syndrome
- Trial name
- NCT00920400
- Where
- Switzerland
- Volunteers
- 287 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastrointestinal Hemorrhage, Anemia
Iron Substitution After Upper Gastro-Intestinal Bleeding
The trial is a double-blind randomized trial designed to examine whether compliant iron therapy (intravenous or oral) for 3 months after discharge increases hemoglobin levels more and faster than no treatment - in patients with…
- Trial name
- NCT00978575
- Testing
- ferricarboxymaltose, Ferrosulfate
- Where
- Denmark
- Volunteers
- 97 people
- Sponsor
- University of Aarhus
Oesophageal Cancer, Gastric Cancer
ReStOre@Home: Feasibility Study of a 12-week Multidisciplinary Telehealth Rehabilitation Programme for Survivors of Upper Gastrointestinal (UGI) Cancer
Feasibility study of a 12-week multidisciplinary telehealth rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer
- Trial name
- ReStOre@Home (NCT04603339)
- Testing
- Multidisciplinary rehabilitation programme delivered via telehealth
- Where
- Ireland
- Volunteers
- 12 people
- Sponsor
- University of Dublin, Trinity College
Dysentery, Dysentery, Bacillary
Safety Study of S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months
The purpose of this study is to evaluate safety of S.flexneriza-S.sonnei Bivalent Conjugate Vaccine in healthy volunteers aged above 3 Months.
- Trial name
- NCT03561181
- Testing
- S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Swallowing Disorders
Follow-up After a Stay in Intensive Rehabilitation for Patients With Swallowing Disorders
Prospective, open-label, randomized, single-center study evaluating the benefit of a months long monthly telephone follow-up for patients with chronic disorders following the after-effects of anti-cancer treatments after an…
- Trial name
- E-CRIL (NCT04859595)
- Testing
- Telephone follow-up
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse
Periodontitis, Surgery--Complications
Periodontitis and Upper gi Post-operative Complications
Periodontitis is a infection of mouth gingival mucosa and connecting tissue. It has been shown in previous studies to have a effect on the risk of heart diseases getting worse and elevate risk in heart surgery.
- Trial name
- NCT03144973
- Testing
- periosafe
- Where
- Finland
- Volunteers
- 256 people
- Sponsor
- Helsinki University Central Hospital
Indigestion, Dyspepsia
A Prospective Multicentre Real-world Assessment of the Efficacy of Danning Tablets in Alleviating Digestive Symptoms
The goal of this observational study is to evaluate if Danning Tablets are effective in alleviating dyspepsia in patients with any of the following digestive symptoms: upper abdominal pain, bloating, loss of appetite, acid reflux…
- Conditions
- Indigestion, Dyspepsia, Bloating, Loss of Appetite
- Trial name
- NCT06755671
- Testing
- Danning Tablet
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Esophageal Neoplasms, Stomach Neoplasms
Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer
Surgery is the cornerstone of treatment for patients with oesophageal or gastric cancer, but while surgical removal of the tumour (oesophagectomy or gastrectomy) may offer the best chance of cure, these are major operations…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385630
- Testing
- Standardized 400kcal semi-liquid meal
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- St. James's Hospital, Ireland
Upper Gastrointestinal Bleeding
Risk Stratification of Patients Presenting With Upper Gastrointestinal Bleeding to the Emergency Department Using AIMS65 Score and Red Cell Distribution Width
The rationale of this study in UGIB patients is to assess whether the prediction of mortality and morbidity using AIMS65 score improves when used in combination with RDW in the emergency department setting.
- Trial name
- RUGBE (NCT04825977)
- Testing
- RISK STRATIFICATION USING AIMS65 SCORE AND RDW
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST)
Multicenter Observational Study of Multimodal AI for Upper GI Mesenchymal Tumor Diagnosis
This study develops a multimodal AI model using endoscopic ultrasound, white-light endoscopy, and clinical information to support the diagnosis of upper GI mesenchymal tumors and the risk stratification of gastric GISTs.
- Conditions
- Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST), Leiomyoma, Schwannoma
- Trial name
- NCT07078136
- Testing
- Multimodal AI Model, Expert Endoscopist Assessment
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Huazhong University of Science and Technology
Stomach Neoplasms, Esophageal Neoplasms
Perioperative Nutrition in Upper Gastrointestinal (GI) Cancer Surgery
The aim of this study is to demonstrate the influence of peri-operative nutrition on the post-operative complications, preservation of lean body mass and length of stay after gastrectomy or oesophagectomy.
- Trial name
- NCT00560846
- Testing
- Impact, Glucose load
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- Dan Azagury
Gallbladder Disease, Biliary Colic
Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree (up to 2-weeks Post-operatively)
The investigators hypothesize that the da Vinci Fluorescence Imaging Vision System provides real-time endoscopic near infrared fluorescence imaging of the biliary anatomy as defined as identifying biliary vessels; either cystic…
- Conditions
- Gallbladder Disease, Biliary Colic, Gallstones
- Trial name
- NCT01410734
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- Intuitive Surgical
Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule
Tissue Characterisation by Endoscopic GI-elastography
In this single centre study we study the use of endoscopic ultrasonography (EUS) combined with elastography in order to separate malignant tissue from benign tissue in and adjacent to the upper gastrointestinal tract.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule, Secondary and Unspecified Malignant Neoplasm of Retroperitoneal Lymph Nodes, Secondary Malignant Neoplasm of Lymph Node
- Trial name
- NCT01360411
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Haukeland University Hospital
Upper Gastrointestinal Bleeding
Capsule Endoscopy for HEmorrhage in the ER
This is a multi-center randomized controlled trial examining the use of Video Capsule Endoscopy (VCE) to discharge low-moderate risk patients with suspected upper gastrointestinal bleeds (UGIB) from the Emergency Department (ED.)…
- Trial name
- CHEER (NCT03458000)
- Testing
- PillCam UGI, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- George Washington University