Clinical trials: Upper Limb Deficits
ADHD
The Efficacy and Safety of PRC-063 in Adult ADHD Patients
The purpose of this randomized, placebo-controlled, double-blind, parallel group study is to evaluate the clinical efficacy and safety of PRC-063 in adults with ADHD
- Trial name
- NCT02139124
- Testing
- PRC-063 25 mg, PRC-063 45 mg, PRC-063 70 mg
- Where
- 38 sites in United States, Canada
- Volunteers
- 375 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Stroke, Acute, Stroke (Subacute)
Inter-Limb Transfer in Acute Stroke
This study aims to investigate whether the improvements achieved through motor skill learning (MSkL) with the ipsilesional upper limb (UL) are transferred to the contralesional UL during the (sub)acute stroke phase, and to…
- Conditions
- Stroke, Acute, Stroke (Subacute), Healthy Individuals (Controls), Chronic Stroke Patients
- Trial name
- MLAS5 (NCT07822633)
- Testing
- REAplan®, Dextrain Manipulandum®
- Where
- 2 sites in Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Attention-deficit/Hyperactivity Disorder
Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder
The purpose of this study is to determine effectiveness of Vyvanse compared to Concerta in adolescents with Attention-deficit/Hyperactivity Disorder (ADHD).
- Trial name
- NCT01552902
- Testing
- Lisdexamfetamine dimesylate, Methylphenidate Hydrochloride
- Where
- 95 sites in United States, Canada and 3 more
- Volunteers
- 549 people
- Sponsor
- Shire
Elbow Fracture, Neurologic Deficits
Fracture and Neurological Injury
The goal of the project is to describe novel factors affecting outcome after elbow fracture surgery with an in-depth evaluation of the role played by neuro inflammation from concomitant peripheral nerve injury or head injury in…
- Trial name
- FIRE (NCT05075382)
- Testing
- Elbow surgery for fracture
- Sponsor
- Université de Montréal
Stress, Sleep
Evaluating the Effects of Nutritional Interventions on Sleep, the Gut Microbiome, Cognition, and Stress.
This will be a double-blind, placebo-controlled, parallel-group trial. Participants who are poor sleepers will be randomised to receive one of two investigational supplements, or a placebo control supplement, over a 28-day…
- Conditions
- Stress, Sleep, Cognition, Nutrition
- Trial name
- NCT07369869
- Testing
- Proprietary 'active' composition 1, Proprietary 'active' composition 2, Inactive control supplement
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Chronic Stroke Survivors
PoNS® Therapy for Gait and Balance Deficits in Chronic Stroke Survivors: A Single-Arm Study
Primary Objective: To further evaluate the aspects of safety related to PoNS therapy in chronic stroke survivors. Secondary Objectives: To further evaluate the efficacy of PoNS on improving dynamic gait and balance, establishing…
- Trial name
- NCT06336720
- Testing
- Portable Neuromodulation Stimulator (PoNS)
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Helius Medical Inc
CVA (Cerebrovascular Accident), Stroke
Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment
Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the…
- Conditions
- CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
- Trial name
- NCT05492513
- Testing
- Grade 1 CI Therapy +Sensory Components
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Stroke (CVA) or TIA, Stroke/Brain Attack
Music Therapy After Stroke (Subacute Phase)
The goal of this longitudinal, single-subject study is to investigate the role of motivation in music therapy for stroke patients within the subacute phase, who experience upper limb and/or attention deficits.
- Trial name
- NCT06291480
- Testing
- Neurologic Music Therapy
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Universiteit Leiden
Stroke
Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke
Patients (UK only) at least 6 months post stroke, with upper limb deficits, may enroll. Patients will be randomized to one of two groups - a group implanted with a device that allows pairing VNS with rehabilitation and a group…
- Trial name
- NCT01669161
- Testing
- Vivistim System, Rehab Only
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- MicroTransponder Inc.
Stroke
Study of Sensory Deficits in the Upper Limb After Stroke
The overall aim of the project is to gain insight in sensory deficits and recovery patterns in the upper limb post stroke and its association with brain lesion localisation.
- Trial name
- NCT01685788
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Attention-deficit/Hyperactivity Disorder, Emotional Dysregulation
A Study to Test the Effects of Centanafadine in Adults With Attention-deficit/Hyperactivity Disorder and Emotional Dysregulation
The primary purpose of this study is to evaluate the efficacy of centanafadine once daily (QD) extended-release (XR) capsules in adults with attention-deficit/hyperactivity disorder (ADHD) and emotional dysregulation (ED).
- Trial name
- NCT07759154
- Testing
- Centanafadine XR
- Where
- 16 sites in United States
- Volunteers
- 80 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Chronic Stroke
Exoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits
This study will evaluate the effects of combining motor learning-based therapy with use of the MyoPro , a wearable exoskeletal myoelectrically controlled orthotic device.
- Trial name
- NCT05296408
- Testing
- motor learning based therapy, MyoPro, Home Exercise Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Upper Limb Deficit, Stroke Gait Rehabilitation
Impact of VNS With Rehab on Gait Post-Stroke
This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.
- Conditions
- Upper Limb Deficit, Stroke Gait Rehabilitation, Stroke
- Trial name
- NCT07643337
- Testing
- Vagus Nerve Stimulation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- State University of New York at Buffalo
Cerebral Palsy
Transcranial Alternating Current Stimulation in Cerebral Palsy (BOOSTTACS)
The present study aims to assess, through a randomized controlled trial (RCT), the efficacy of transcranial alternating current stimulation (tACS) in enhancing the functional changes due to an intensive motor training in children…
- Trial name
- BOOSTTACS (NCT06372041)
- Testing
- transcranial Alternating Current Stimulation
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS Eugenio Medea
Stroke
Remediation of the Non-Paretic Arm in Stroke
Stroke survivors with severe contralesional paresis often have substantial control and coordination deficits in the non-paretic arm.
- Trial name
- NCT03062930
- Testing
- Track 1, Track 2
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Milton S. Hershey Medical Center
Stroke, Upper Limb Motor Deficit
Prediction of Post-stroke Motor Recovery
The prediction of motor recovery in the acute phase of stroke is crucial for several clinical reasons: (i) informing the patient and his relatives, (ii) helping to identify the patient's endorsement (return home or…
- Trial name
- PREP-AVC (NCT04574037)
- Testing
- Clinical scores such as SAFE score, NIHSS; demographic data such as age and electrophysiological data (such as the absence/presence of Motor evoked potential)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Attention Deficit Disorder With Hyperactivity
A Trial to Characterize Differences in Blood Levels of Different Lots of Centanafadine QD XR and to Understand the Effect of Food on Blood Levels
The purpose of this study is to evaluate the dose strength equivalence of to-be-marketed (TBM) centanafadine (CTN) once daily (QD) extended release (XR) when administered as 2 capsules of 164.4 milligrams (mg) or as a single…
- Trial name
- NCT07253441
- Testing
- CTN XR (TBM), CTN SR, CTN XR (Clin)
- Where
- 2 sites in United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3
Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb
Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical…
- Conditions
- Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy 4
- Trial name
- NCT06300996
- Testing
- Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Marco Capogrosso
Upper Limb Sensorimotor Deficits
Feasibility and Cost of Robot-assisted Upper Limb Rehabilitation With Different Levels of Supervision
Upper limb impairments are often a result of neurological or traumatic injuries (e.g., stroke, traumatic brain injuries). These impairments may decrease independence in performing activities of daily living, severely affecting…
- Trial name
- RHB Clinic (NCT06725784)
- Testing
- ReHandyBot
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Swiss Federal Institute of Technology