Clinical trials: Upper Limb Dysfunction
Stroke, Stroke with Hemiparesis
Study of Hemodynamic Markers of Upper Extremity Motor Dysfunction in Stroke Patients Using Functional Near Infrared Spectroscopy (fNIRS)
The aim of the study was to explore potential pathways for recovery and adaptation of the motor cortex by examining cerebral blood flow characteristics and hemodynamic markers analyzed by functional near-infrared spectroscopy…
- Conditions
- Stroke, Stroke with Hemiparesis, Stroke, Ischemic
- Trial name
- NCT06806397
- Testing
- Stimulus response task
- Where
- 2 sites in Russia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Hemiplegic Cerebral Palsy, Mirror Hands
Mirror Therapy in Children With Hemiparetic Cerebral Palsy
Cerebral palsy (CP) is a neurodevelopmental disorder that frequently impairs upper extremity motor control and hand function, resulting in limitations in daily activities.
- Conditions
- Hemiplegic Cerebral Palsy, Mirror Hands, Upper Extremity Dysfunction, Motor Activity
- Trial name
- NCT07734376
- Testing
- Mirror Therapy, Conventional Physiotherapy
- Volunteers
- 26 people
- Sponsor
- Marmara University
Parkinson Disease, Upper Extremity Dysfunction
Leap Motion Controller on the Functionality of Upper Limbs in Parkinson's Disease
Is treatment with the Leap Motion Controller device effective for upper limb functionality in individuals with Parkinson's Disease? The present study presents two hypotheses: True hypothesis: There is an improvement in the…
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Therapy-Related MDS
- Trial name
- NCT04796246
- Testing
- Leap Motion Controller, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Upper Extremity Dysfunction, Brain Diseases
Feasibility of Virtual Reality Games Using Head-mounted Display on Patients With Brain Disorders
Because virtual reality can provide more enriched environment, repetitive goal-oriented tasks, and increased patients' interest and motivation, it is expected to stimulate neuroplasticity of injured brain and promote recovery in…
- Trial name
- NCT03196739
- Testing
- Virtual rehabilitation
- Where
- 2 sites in South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Traumatic Brain Injury, Upper Extremity Dysfunction
TeleRehab to Restore Upper Limb Function in People With Chronic TBI
The study aims to inform the subsequent large-scale clinical trial focused on using telerehabilitation techniques and technologies to improve upper limb function and quality of life.
- Conditions
- Traumatic Brain Injury, Upper Extremity Dysfunction, Disability Physical
- Trial name
- NCT06184932
- Testing
- HAHE, Exergame
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Acute Ischemic Stroke
Eptifibatide in Endovascular Treatment of Acute Ischemic Stroke (EPOCH)
The study is a single-arm, open-label, multicenter clinical trial.The primary purpose of this trial is to evaluate the incidence of symptomatic intracranial hemorrhage in patients with acute ischemic stroke within 48 hours after…
- Trial name
- NCT03844594
- Testing
- Eptifibatide Injection
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Hemiplegia, Stroke
Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic Patients
Upper extremity impairment in hemiplegic patients significantly impacts daily activities and reduces quality of life. Although traditional rehabilitation methods can help, some patients experience limited progress.
- Conditions
- Hemiplegia, Stroke, Upper Extremity Dysfunction
- Trial name
- NCT07018336
- Testing
- Mirror Therapy, Virtual Reality (VR) Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istinye University
Digestive Symptoms, Gastrointestinal Symptoms
A Study of Single and Combination Lipase Dietary Supplements to Increase Fatty Acid Absorption in Generally Health Adults
This study aims to investigate the effect of two digestive enzyme dietary supplements, THRIVE4U™ TG Lipase and THRIVE4U™ Spectrum Lipases in supporting the breakdown of fat after a meal.
- Conditions
- Digestive Symptoms, Gastrointestinal Symptoms, Healthy, Impaired Pancreatic Function
- Trial name
- NCT07893288
- Testing
- THRIVE4U™ TG Lipase, THRIVE4U™ Spectrum Lipases
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danisco
Upper Extremity Dysfunction
Movement Enhancing Device for Children
The purpose of this study is to assess: 1) how infants move their bodies to explore, play, and solve problems, 2) if this is different in a high-risk group of infants, and 3) if these abilities can be advanced in a high-risk…
- Trial name
- NCT01959581
- Testing
- Movement Enhancing Device
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cancer of the Prostate, Cancer
Cognitive Remediation Therapy (CRT) for Adults Treated for Cancer
This study is to determine the safety, feasibility and acceptability of an 8-week cognitive remediation training (CRT) in patients treated for cancer.
- Trial name
- CaCRT (NCT03285048)
- Testing
- Cognitive Remediation Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Breast Cancer Survivor
Baduanjin Exercise on Upper Limb Dysfunction Among Breast Cancer Survivors
The goal of this clinical trial is to learn if Baduanjin exercise could be adopted by breast cancer survivors and improve their upper limb dysfunction.
- Trial name
- NCT07522593
- Testing
- Baduanjin exercise
- Where
- China
- Volunteers
- 76 people
- Sponsor
- University of Southern Queensland
Non-alcoholic Fatty Liver Disease
A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH
The purpose of this study is to assess the safety and efficacy of efimosfermin alfa in the resolution of steatohepatitis and improvement of liver-related clinical outcome compared to placebo in individuals with MASH and…
- Trial name
- ZENITH-1 (NCT07221227)
- Testing
- Efimosfermin alfa
- Where
- 91 sites in United States, Australia and 7 more
- Volunteers
- 1,200 people
- Sponsor
- GlaxoSmithKline
Non-alcoholic Fatty Liver Disease
A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH
This study will evaluate the safety and tolerability of Efimosfermin Alfa for participants with known or suspected MASH with fibrosis consistent with stage F2 or F3.
- Trial name
- ZENITH-2 (NCT07221188)
- Testing
- Efimosfermin Alfa
- Where
- 66 sites in United States, Australia and 6 more
- Volunteers
- 1,250 people
- Sponsor
- GlaxoSmithKline
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County
Stroke, Cardiovascular, Cognitive Impairment
OptiCogs: A Multicomponent Intervention to Rehabilitate Cognitive Impairment in People Post-stroke
OptiCogs Online is a complex multicomponent intervention comprising of cognitive, physical activity and educational components.
- Trial name
- NCT05414539
- Testing
- OptiCogs Online
- Where
- Ireland
- Volunteers
- 9 people
- Sponsor
- University of Limerick
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Stroke, Upper Extremity Dysfunction
REHABOTICS: Physiotherapy for Hand Spasticity After Stroke Using Robotics and AR Serious Games
Rehabotics is a comprehensive rehabilitation system designed to deliver individualized upper-limb therapy for patients with motor impairments, particularly after stroke.
- Conditions
- Stroke, Upper Extremity Dysfunction, Spasticity Post Stroke
- Trial name
- NCT07468149
- Testing
- Rehabotics Physiotherapy
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Pantelis Syringas
Breast Cancer, Shoulder Dysfunction
Exercise Prehabilitation of Breast Cancer
This prospective prehabilitation trial evaluated the effectiveness of an individualized exercise program initiated before breast cancer surgery and maintained for 12 months.
- Conditions
- Breast Cancer, Shoulder Dysfunction, Quality of Life, Postoperative Recovery
- Trial name
- Prehab of BC (NCT07240584)
- Testing
- Exercise-Based Prehabilitation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Breast Cancer, FIT-HaNSA
The Validity and Reliability of FIT-HaNSA in Breast Cancer Patients
Breast cancer is the most common type of cancer among women and covers 25% of all cancers. After mastectomy and reconstruction, many patients develop various upper extremity complications such as joint movement limitation, pain…
- Conditions
- Breast Cancer, FIT-HaNSA, Upper Extremity Dysfunction
- Trial name
- NCT04795778
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Upper Extremity Dysfunction, Stroke
taVNS Paired With Motor Training for Upper-extremity Rehabilitation in Stroke Patients
Background: Recently, there has been increasing attention on the application of transcutaneous auricular vagus nerve stimulation (taVNS) in ischemic stroke.
- Trial name
- NCT05943431
- Testing
- paired taVNS, Unpaired taVNS
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Qiuyou Xie