Clinical trials: Upper Limb Function
Cerebral Palsy, Upper Extremity Paresis
Effectiveness of Armeo Spring Robotic Therapy in the Function of the Upper Limb of Children With Unilateral Spastic Cerebral Palsy Infiltrated With Botulinum Toxin
Background: Unilateral spastic cerebral palsy (CP) generates an impact on daily activities, mainly due to the functional limitation of the affected upper limb.
- Trial name
- NCT04554238
- Testing
- Armeo spring, Occupational Therapy
- Where
- Chile
- Volunteers
- 23 people
- Sponsor
- Sociedad Pro Ayuda del Niño Lisiado
Stroke, Upper Extremity Paresis
The Effect of Vibration Therapy and Mirror Therapy on Upper Limb Function in Patients With Stroke
Due to lack of evidence about the difference between the effects of Vibration Therapy and Mirror Therapy on stroke patients, this study aims at comparing the two, in the context of hemiparesis, to help patients improve hand motor…
- Trial name
- NCT06126978
- Testing
- Vibration Therapy (Galileo Dela Interface), Mirror Therapy ( Mirror Box)
- Volunteers
- 36 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Spinal Cord Injury Cervical
Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury
The main goal of this pilot study is to find the best ways to use transcutaneous spinal cord stimulation (scTS) to improve hand function in children with spinal cord injuries (SCI).
- Trial name
- NCT06489106
- Testing
- Activity based upper extremity training with and without stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Severe Mental Disorder
Aerobic, Resistance and Inspiratory Muscle Training in Adults With Severe Mental Disorder
People with severe mental disorder, such as schizophrenia, bipolar disorder or major depression, tend to have poorer physical health and a shorter life expectancy than the general population.
- Trial name
- NCT07758049
- Testing
- Supervised multicomponent exercise programme
- Where
- Spain
- Volunteers
- 49 people
- Sponsor
- Universidad Pablo de Olavide
Cerebral Palsy, Hemiplegic Cerebral Palsy
The Effect of Music Therapy on Upper Extremity Functions and Quality Of Life in Individuals With Cerebral Palsy
The main purpose of this study is to investigate the effect of music therapy on the upper extremity functions and quality of life of individuals with Cerebral Palsy (CP).
- Conditions
- Cerebral Palsy, Hemiplegic Cerebral Palsy, Music Therapy
- Trial name
- NCT06209840
- Testing
- Control Group, Study (Music) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara Yildirim Beyazıt University
Sports Physical Therapy
Plyometric Exercises Versus Wii Training in Children with Unilateral Cerebral Palsy
Plyometric training includes muscle contraction that moves rapidly from the eccentric to the concentric phase of movement while using proper biomechanics.
- Trial name
- NCT05313633
- Testing
- Occupational therapy, Plyometric training, Wii training
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Cerebral Palsy
Synchronous Telerehabilitation vs Face to Face Method for Upper Extremity Functions in Children With Hemiparetic CP
The aim of this study is to investigate the effectiveness of synchronous telerehabilitation on improving upper extremity function in children with hemiparetic cerebral palsy.
- Trial name
- NCT05522452
- Testing
- Telerehabilitation, Face to face rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University - Cerrahpasa
Heart Transplantation
A Study of Daclizumab (Zenapax) in Combination With Mycophenolate Mofetil (CellCept) and Sirolimus in Prevention of Acute Rejection in Heart Transplant Participants
This study will evaluate the efficacy and safety of intravenous daclizumab in combination with oral mycophenolate mofetil and oral sirolimus in participants receiving a heart transplant, and at risk of impaired kidney function.
- Trial name
- NCT02554955
- Testing
- Daclizumab, Mycophenolate mofetil, Silrolimus
- Where
- 14 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Cerebral Palsy
Cerebral Palsy Upper Extremity Orthotic Device
Upper extremity therapies for children with cerebral palsy (CP) have been validated for improving function in higher functioning patients.
- Trial name
- NCT05024409
- Testing
- Upper Extremity Orthotic, Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (AU) (NCT07757698)
- Testing
- Transcatheter mitral valve repair
- Volunteers
- 15 people
- Sponsor
- Polares Medical SA
Spasticity, Muscle, Stroke
Multimodal Instrumented Assessment of Post-stroke Elbow
The proposed clinical trial will employ the NEUROExos Elbow Module (NEEM), an active robotic exoskeleton, for the passive mobilization and active training of elbow flexion and extension in 60 sub-acute and chronic stroke patients…
- Conditions
- Spasticity, Muscle, Stroke, Upper Limb
- Trial name
- NCT04484571
- Testing
- Neuroexsos elbow module
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda USL Toscana Nord Ovest
HNSCC
Single-arm Study With Bimiralisib in Patients With HNSCC Harboring NOTCH1 Loss of Function Mutations
Preclinical data and limited clinical evidence suggest that Head and Neck Squameous Cell Carcinoma tumors harboring certain mutations may respond well to PI3K/mTOR inhibition (phosphatidylinositol-3-kinase/ mammalian target of…
- Trial name
- HNSCC (NCT03740100)
- Testing
- Bimiralisib
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Stroke Patient
Mirror Therapy Versus Repetitive Facilitation Exercise on Upper Limb Function
The objective of the study is to determine the effects of Mirror therapy on upper limb function in a post-stroke patient, To determine the effects of Repetitive Facilitation Exercise on upper limb function in a post-stroke…
- Trial name
- NCT04468945
- Testing
- mirror box therapy, Repetitive Facilitation Exercise
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (FR) (NCT07757607)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
Peripheral Nerve Injury Upper Limb
BMAC Nerve Allograft Study
This study is a prospective, multi-center, proof of principle, phase I human safety study evaluating the sequential treatments of the Avance Nerve Graft, a commercially available decellularized processed peripheral nerve…
- Trial name
- NCT03964129
- Testing
- Avance Nerve Graft with Autologous BMAC
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Brooke Army Medical Center
Carpal Tunnel Syndrome, Ibuprofen
Ibuprofen and Neural Mobilization Treatment in Carpal Tunnel Syndrome.
In the present investigation, the pain reduction effect of median nerve neural mobilization and oral ibuprofen treatments will be compared to those produced by the absence of treatment, in subjects who suffer the signs and…
- Conditions
- Carpal Tunnel Syndrome, Ibuprofen, Pain Management, Pain, Chronic
- Trial name
- NCT04328805
- Testing
- ibuprofen tablets, Median nerve neural mobilization
- Where
- Venezuela
- Volunteers
- 123 people
- Sponsor
- Universidad Europea de Madrid
Parkinson Disease, Upper Extremity Dysfunction
Effectiveness of Noninvasive Vagus Stimulation for Upper Extremity in Parkinson's Disease
Vagus nerve stimulation in the treatment of PD is a non-pharmacological intervention with the potential to improve gait, cognition, fatigue, and autonomic functions, but more evidence is needed for VSS in the treatment of PD.
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Tremor
- Trial name
- NCT05456451
- Testing
- noninvasive vagus nerve srimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cerebral Palsy, Spastic, Cerebral Palsy, Dyskinetic
Functional Benefits of Multisite Surgery for the Upper Limb of Children With Cerebral Palsy
The aim of the study is to investigate the impact of individualized multisite neuro-orthopedic surgery of the upper limb in children with Cerebral Palsy on unilateral functional capacities and bimanual performance.
- Conditions
- Cerebral Palsy, Spastic, Cerebral Palsy, Dyskinetic, Infantile Hemiplegic Cerebral Palsy
- Trial name
- NCT04395729
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
Upper Extremity Dysfunction, Traumatic Brain Injury
Targeted Noninvasive Brain Stimulation (T-NIBS) to Improve Hand Motor Functions in Acquired Brain Injury
Acquired Brain Injury (TBI) is a serious medical and health problem in the US. Individuals with an acquired brain injury due to stroke and Traumatic Brain Injury (TBI) commonly suffer from upper extremity physical impairments…
- Trial name
- NCT04057105
- Testing
- Active High-definition Transcranial Direct Current Stimulation (HD-tDCS), MusicGlove
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kessler Foundation
Stroke
Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation in Chronic Stroke
Comparison of real transcranial direct current stimulation (tDCS) and sham tDCS combined with robot training for upper extremity rehabilitation in subjects with chronic stroke - delayed start study.
- Trial name
- NCT04005131
- Testing
- Robot and tDCS on-line
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- National Rehabilitation Center, Seoul, Korea