Clinical trials: Upper Limb Surgery
Male Circumcision
Safety Study of the PrePex Device for Non-Surgical Adult Male Circumcision During Phased in National Implementation in an Effort to Prevent the Spread of HIV
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision.
- Trial name
- RMC-07 (NCT01921608)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Peripheral Nerve Injury Upper Limb, Peripheral Nerve Injury (PNI)
This Study Will Evaluate the Effectiveness of NTX-001, a Surgical Nerve Repair Product When Used in People With Upper Extremity Nerve Lacerations.
NTX-001 is a single use surgical product intended for use in conjunction with standard suture neurorrhaphy of severed nerves in patients between 18 and 80.
- Trial name
- NCT06616025
- Testing
- NTX-001 (PEG-Fusion)
- Where
- 25 sites in United States
- Volunteers
- 98 people
- Sponsor
- Neuraptive Therapeutics Inc.
Colorectal Surgery
Prospective, Randomized, Parallel-arm Clinical Trial of CleanCision or Alexis O in Elective Colorectal Surgery
Surgical site infection (SSI) remains a problem in colorectal surgery. Strategies to reduce the incidence of SSI following colorectal surgery are important to improve overall patient outcomes, reduce healthcare-associated costs…
- Trial name
- NCT03816995
- Testing
- CleanCision Wound Retraction and Protection System, Alexis O Wound Protector
- Where
- United States
- Volunteers
- 702 people
- Sponsor
- Scott Steele
Lymphedema Arm
Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema
The purpose of this research is to determine the preferred microbubble agent (Lumason®, Optison®, and Definity®) for lymphatic channel visualization by ultrasound.
- Trial name
- CASTLE (NCT05613946)
- Testing
- Lumason, Optison, Definity
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Wound Healing
Clinical Efficacy of a Chlorhexidine-based Mouth-rinse Containing Citrus Aurantium Amara
The primary objective of the study is the evaluation of efficacy of a mouthwash cointaining Chlorexidine (CHX) 0.09% + HA + Citrox (test group) on the quality of wound healing and the presence plaque formation and gingival…
- Trial name
- CUR_01 (NCT06738342)
- Testing
- CHX 0.09% + Citrox + HA, CHX 0.12%
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Disorder of Upper Extremity
Retroclavicular Versus Coracoid Approach for Infraclavicular Brachial Plexus Block
The primary aim of this study is to compare needle tip visibility between the coracoid approach and retroclavicular approach for infraclavicular brachial plexus block in patients undergoing elective upper limb surgery.
- Trial name
- NCT02673086
- Testing
- coracoid approach, retroclavicular approach
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Antalya Training and Research Hospital
Postoperative Pain, Upper Extremity Fracture
Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic Surgery
This randomized controlled trial compared three local anesthetic solutions for ultrasound-guided supraclavicular brachial plexus block in adults aged 18 to 59 years undergoing upper limb orthopedic and trauma surgery at a general…
- Conditions
- Postoperative Pain, Upper Extremity Fracture, Anesthesia, Conduction
- Trial name
- NCT07907666
- Testing
- ropivacaine, lidocaine, lidocaine with epinephrine
- Where
- Mexico
- Volunteers
- 138 people
- Sponsor
- Instituto Mexicano del Seguro Social
Cataracts
A Real-World Registry to Investigate the Performance of LenSx® Laser in Chinese Patients
The purpose of this study is to investigate the performance of LenSx® Laser in femtosecond laser-assisted cataract surgery (FLACS) in real-world medical practice in Chinese patients.
- Trial name
- NCT02396719
- Testing
- LenSx® Laser
- Where
- China
- Volunteers
- 1,541 people
- Sponsor
- Alcon Research
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
Radiosurgery Before Surgery for the Treatment of Brain Metastases
This early phase I trial identifies the side effects of stereotactic radiosurgery before surgery in treating patients with cancer that has spread to the brain (brain metastases).
- Trial name
- NCT04895592
- Testing
- Dexamethasone, Resection, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Regional Anesthesia Block, Brachial Plexus Blocks
Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries
The aim of the study is to compare the onset time of the costoclavicular approach of brachial plexus block with that of the lateral-sagittal infraclavicular approach in adults distal upper limb surgeries.
- Trial name
- NCT07517809
- Testing
- Costoclavicular brachial plexus block, Lateral-sagittal infraclavicular brachial plexus block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Melanoma
PROSECCO: A Phase 2, Single Arm, Neoadjuvant Study Evaluating Combination Cemiplimab, Fianlimab, And Ipilimumab In Patients With Surgically Resectable Melanoma
This is a phase II study testing the safety and preliminary efficacy of triplet ICB in treatment naïve patients with clinical stage III or oligometastatic stage IV melanoma with resectable disease.
- Trial name
- NCT07511036
- Testing
- Cemiplimab, Lpilimumab, Fianlimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Surgery
Comparison of Blood Pressure Measurements in Upper and Lower Extremities in Children Under General Anesthesia
There is very little information comparing non-invasive blood pressure (BP) readings obtained from upper and lower limbs, as well as comparing invasive and non-invasive blood pressures in the children under anesthesia.
- Trial name
- NCT03220906
- Testing
- Blood pressure measurement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Nationwide Children's Hospital
Surgical Site Infection, Colon Surgery
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- D-PLEX312 (NCT04411199)
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 58 sites in United States, Bosnia and Herzegovina and 11 more
- Volunteers
- 975 people
- Sponsor
- PolyPid Ltd.
Carcinoma, Non-Small-Cell Lung
A Trial of Sugemalimab and Chemotherapy in Unresectable Stage III NSCLC
The goal of this phase II, open-label, single-arm study is to evaluate the efficacy and safety of induction immunotherapy and chemotherapy followed by the multidisciplinary team (MDT)-guided radiotherapy or surgery in…
- Trial name
- NCT05940532
- Testing
- Sugemalimab and Chemotherapy
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Hunan Cancer Hospital
Lateral Epicondylitis, Tennis Elbow
Comparison of Surgical Interventions for Lateral Epicondylitis: A Prospective Study
The investigator hopes to determine if one of three current standard of care surgeries for lateral epicondylitis (tennis elbow) is more effective than others.
- Trial name
- NCT01618487
- Testing
- Arthroscopic tenotomy, Open tenotomy, Debridement and repair
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Pancreas Cancer, Pancreas Disease
Intra-operative Application of HEMOPATCH to the Pancreatic Stump to Prevent Post-operative Pancreatic Fistula Following Distal Pancreatectomy
Despite improvements and advances in pancreas surgery, about 30-35% of patients who have pancreas surgery develop a type of complication called a pancreatic fistula.
- Conditions
- Pancreas Cancer, Pancreas Disease, Pancreas Adenocarcinoma, Pancreas; Fistula
- Trial name
- PATCH-DP (NCT03410914)
- Testing
- Hemopatch
- Where
- 7 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer
Timing of Specific Exercise Therapy After Breast Cancer Surgery: Early Versus Delayed Initiation
This single-center, parallel-group randomized controlled trial (RCT) will compare two timings for initiating specific exercise therapy after breast cancer surgery.
- Trial name
- BEST-Timing (NCT06918184)
- Testing
- Specific Exercise Therapy
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Al Hayah University In Cairo
Acute Coronary Syndrome
Ticagrelor Removal Study Using CytoSorb® 300 mL Device During CPB in Patients Undergoing Emergent Cardiothoracic Surgery
The aim of CyTation is to demonstrate intra-operative removal of ticagrelor by CytoSorb® hemadsorption in patients on ticagrelor undergoing emergent cardiothoracic surgery requiring CPB, using platelet reactivity to adenosine…
- Trial name
- CyTation (NCT04625764)
- Testing
- Blood sampling and analysis
- Where
- 4 sites in Germany, Luxembourg
- Volunteers
- 6 people
- Sponsor
- CytoSorbents Europe GmbH
Tennis Elbow
Non-Surgical Treatment Approaches in Patients With Newly Diagnosed Lateral Epicondylitis: A Randomized Clinical Trial
Lateral epicondylitis (tennis elbow) is a painful musculoskeletal condition, which is considered to be due to overuse, over-stress or over-exertion of the wrist extensors of the forearm, especially extensor carpi radialis brevi.
- Trial name
- NCT02930304
- Testing
- first physiotherapy, second physiotherapy, third physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Fracture of Shoulder and Upper Arm
Exparel for Postoperative Pain Management in Shoulder Surgery
The purpose of this study is to compare the effect of liposomal Bupivacaine infiltration into the shoulder to continues nerve block with Bupivacaine on postoperative pain control and functional outcomes.
- Trial name
- NCT02472314
- Testing
- 1.3% Liposomal Bupivacaine, 0.125% Bupivacaine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wayne State University