Clinical trials: Upper Limb Surgery
Open Angle Glaucoma
Study of OMNI System in OAG (GEMINI)
This study will prospectively assess the clinical effect of ab-interno transluminal viscoelastic delivery and trabeculotomy performed using the OMNI Surgical System in combination with Cataract Extraction on intraocular pressure…
- Trial name
- NCT03861169
- Testing
- Transluminal viscoelastic delivery and trabeculotomy
- Where
- 15 sites in United States
- Volunteers
- 209 people
- Sponsor
- Sight Sciences, Inc.
Resectable Cholangiocarcinoma, Stage IB Intrahepatic Cholangiocarcinoma AJCC v8
Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer
This phase II trial studies how well gemcitabine, cisplatin, and nab-paclitaxel work before surgery in treating participants with high-risk bile duct cancer in the liver (intrahepatic cholangiocarcinoma).
- Conditions
- Resectable Cholangiocarcinoma, Stage IB Intrahepatic Cholangiocarcinoma AJCC v8, Stage II Intrahepatic Cholangiocarcinoma AJCC v8, Stage III Intrahepatic Cholangiocarcinoma AJCC v8
- Trial name
- NCT03579771
- Testing
- Cisplatin, Gemcitabine, Nab-paclitaxel
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Breast Surgery
Pectoralis Block vs Paravertebral Nerve Blocks for Breast Surgery
Following painful surgical procedures of the breast, postoperative analgesia is often provided with a nerve block called a "paravertebral" block.
- Trial name
- NCT04742309
- Testing
- Pecs-2 block (single injection), Paravertebral block (single injection)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of California, San Diego
Inguinal Hernia, Ventral Hernia
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Hernia Surgery (Enable Hernia Repair)
A prospective, multicenter, single-arm pivotal study will be performed with 192 subjects enrolled to have an inguinal or ventral robotic hernia repair procedure using the Medtronic Hugo™ RAS system.
- Trial name
- NCT06445504
- Testing
- Robotic-Assisted Surgery (RAS) Hernia Repair Surgery
- Where
- 7 sites in United States
- Volunteers
- 206 people
- Sponsor
- Medtronic - MITG
Triple Negative Breast Cancer, Breast Cancer
Trilaciclib, a CDK4/6 Inhibitor, in Patients With Early-Stage Triple Negative Breast Cancer
The purpose of this study is to evaluate the mechanism of action, as well as the safety and efficacy of trilaciclib in combination with standard of care treatment in the neoadjuvant setting of early-stage triple negative breast…
- Trial name
- NCT05112536
- Testing
- Trilaciclib, Cylophosphamide, Doxorubicin
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- G1 Therapeutics, Inc.
Bladder Cancer
A Study of Intravesical Qapzola (Apaziquone) as a Surgical Adjuvant in Participants Undergoing Transurethral Resection of Bladder Tumor (TURBT)
This is a randomized, multicenter, two-arm, double-blind, placebo-controlled study of Qapzola in participants with low- to intermediate-risk non-muscle invasive bladder cancer (NMIBC), assessed according to the 2016 American…
- Trial name
- NCT03224182
- Testing
- Qapzola
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Rotator Cuff Injuries, Shoulder Disease
Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery
Postoperative pain remains undertreated with inadequate analgesic options. Opioids have well-known limitations for both individuals and society; single-injection and continuous peripheral nerve blocks provide intense analgesia…
- Conditions
- Rotator Cuff Injuries, Shoulder Disease, Hallux Valgus, Ankle Arthropathy
- Trial name
- NCT06818708
- Testing
- Experimental Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Breast Cancer
Pilot Study for a Prospective Surveillance Program for Rehabilitation Following Surgery for Breast Cancer
Breast cancer treatment often results in long-term arm morbidity. A prospective surveillance model with arm assessment pre-surgery followed by ongoing surveillance and targeted physiotherapy treatment after breast cancer surgery…
- Trial name
- NCT02754427
- Testing
- Prospective Surveillance Group, Education Group
- Volunteers
- 41 people
- Sponsor
- University of British Columbia
Hand Injuries, Wrist Injuries
Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery
The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.
- Conditions
- Hand Injuries, Wrist Injuries, Finger Injuries
- Trial name
- NCT02058303
- Testing
- Exparel Forearm block, Bupivacaine supraclavicular block
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Hemorrhage, Surgical
Clinical Safety and Performance of GATT-Patch in Open Liver Surgery
The purpose of this study is to determine the clinical safety and performance of GATT-Patch for management of haemorrhage during elective open liver surgery.
- Trial name
- NCT04819945
- Testing
- GATT-Patch
- Where
- 3 sites in Netherlands
- Volunteers
- 56 people
- Sponsor
- GATT Technologies BV
Surgical Site Infection, Colon Surgery
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- D-PLEX312 (NCT04411199)
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 58 sites in United States, Bosnia and Herzegovina and 11 more
- Volunteers
- 975 people
- Sponsor
- PolyPid Ltd.
Fracture of Shoulder and Upper Arm
Exparel for Postoperative Pain Management in Shoulder Surgery
The purpose of this study is to compare the effect of liposomal Bupivacaine infiltration into the shoulder to continues nerve block with Bupivacaine on postoperative pain control and functional outcomes.
- Trial name
- NCT02472314
- Testing
- 1.3% Liposomal Bupivacaine, 0.125% Bupivacaine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wayne State University
Mitral Stenosis With Insufficiency, Functional Mitral Regurgitation
AVJ-514 Japan Trial
The objective of the study is to confirm the reproducibility of the evidence of safety and efficacy of AVJ-514 System technology in Japanese subjects who have been deemed difficult for mitral valve surgery by the local site heart…
- Conditions
- Mitral Stenosis With Insufficiency, Functional Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence
- Trial name
- NCT02520310
- Testing
- AVJ-514
- Where
- 6 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Lung Cancer, Lung Cancer Metastatic
Safety of PDT-Photofrin® Prior to Lung Surgery
This research study is being conducted to assess the safety of PDT in subjects with peripherally located malignant tumors in lung parenchyma prior to surgical resection. It will involve up to 10 sites in USA.
- Trial name
- NCT03344861
- Testing
- Porfimer Sodium, Fiber optic
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Concordia Laboratories Inc.
Breast Surgery
Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Following painful surgical procedures of the breast, postoperative analgesia is often provided with a paravertebral nerve block (PVB).
- Trial name
- NCT03860974
- Testing
- Serratus Plane block (single injection), Paravertebral block (single injection)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.
New Surgical Scars, Scars
Laser Treatment for Fresh Surgical Scars and Mature Scars
The purpose of this study is to measure the effectiveness of the RevLite Laser in the treatment of both fresh surgical scars and mature/older scars.
- Trial name
- NCT01030198
- Testing
- RevLite (Laser Treatment)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Cynosure, Inc.
Surgery
Digital Prehabilitation for Patients Undergoing Major Elective Surgery
Prehabilitation describes the process of improving someone's functional capacity before major surgery. Prehabilitation commonly focuses on exercise training, as fitness level is a predictor of surgical outcomes - the fitter you…
- Trial name
- NCT06137781
- Testing
- Six weeks of digital prehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Urothelial Cancer
Safety and Efficacy of Pemigatinib in Patients With High-risk Urothelial Cancer After Radical Surgery
The purpose of this clinical trial is to demonstrate the benefit of Pemigatinib, a drug that has indicated promising effects for relapse free survival in molecularly-selected, high-risk patients with urothelial carcinoma (UC) who…
- Trial name
- PEGASUS (NCT04294277)
- Testing
- Pemigatinib
- Where
- 5 sites in Italy
- Volunteers
- 2 people
- Sponsor
- European Association of Urology Research Foundation
Kidney Diseases, ESRD
Safety and Efficacy of Angiotech Vascular Wrap Paclitaxel-Eluting Mesh for Hemodialysis Vascular Access
This is a multi-center clinical study in subjects requiring arteriovenous grafts in the upper extremity for hemodialysis access. All subjects will provide informed consent before undergoing any study procedures.
- Trial name
- NCT00448708
- Testing
- Vascular Wrap Paclitaxel-Eluting Mesh, Lifespan® ePTFE Vascular Graft
- Where
- 33 sites in United States
- Volunteers
- 222 people
- Sponsor
- Angiotech Pharmaceuticals