Clinical trials: Uremic Toxin
To Evaluate the Clearance Rate of Uremic Toxin by HFR
Hemodiafiltration With Endogenous Reinfusion on Uremic Toxins Clearance of Maintenance Hemodialysis Patients
1.1Primary Objective To evaluate the clearance rate of uremic toxin β2-microglobulin (β2-MG), indoxyl sulfate and λ-free light chain (λFLC) by HFR.
- Trial name
- NCT06002529
- Testing
- HFR
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Chronic Kidney Diseases, Cachexia
CKD Cachexia and Gut Microbiome
Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main…
- Trial name
- DYNAMICA (NCT06986265)
- Testing
- Collection of clinical data and biological sampling
- Where
- 2 sites in Belgium
- Volunteers
- 157 people
- Sponsor
- Université Catholique de Louvain
Renal Failure, Multi Organ Failure
Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure.
- Trial name
- NCT00752245
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
End-stage Renal Disease
Sodium Chloride and Protein-Bound Toxin Removal in Hemodiafiltration
An increase of the free fraction may allow a better removal of of protein-bound uremic toxins during dialysis. During predilution hemodiafiltration, the sodium chloride (NaCl) concentration will be increased in the infusion fluid…
- Trial name
- NCT01923961
- Testing
- HDF NaCl, Hemodialysis, Standard Predilution Hemodiafiltration
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- EXcorLab GmbH
Chronic Renal Failure
Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis
Dialysis patients, who decide to switch from standard dialysis (3 times 240-270 min/week) to nocturnal dialysis (3 times 480 min/week), will be followed.
- Trial name
- NCT00766792
- Testing
- Nocturnal dialysis, Standard dialysis
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Ghent
Inflammation
Hemo Filtration Reinfusion (HFR) Clearance Efficiency Towards P-bound Toxins and Effects on Inflammatory and Endothelial Damage Markers
The aim of this study is to compare purification efficiency of HFR in terms of clearance of protein-bound toxins and the effects on markers of inflammation and endothelial damage, in comparison to HF-HD and OL-HDF.
- Trial name
- SUPREMO (NCT02240004)
- Testing
- SUPRA HFR
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Hemodialysis
NATURE 3.2_New Approach for the Reduction of REnal Uremic Toxins
The objective of the pilot study is to validate a combined approach based on the use of an innovative symbiotic and an innovative dialysis cartridge in patients on hemodialysis (HD).
- Trial name
- NATURE32 (NCT03946176)
- Testing
- Symbiotic, DVB cartridge
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Hemodialysis, Kidney Failure Chronic
Pea Fibre in Hemodialysis
Background and problem Chronic kidney disease (CKD) affects a large share of adults worldwide and is a growing public-health concern.
- Trial name
- MUFIN (NCT07544797)
- Testing
- praebiotic inner fermentable pea fibres, Control
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Uremic Toxins, Haemodynamic Stability
Uremic Toxin Removal and Hemodynamics in Long-hour Hemodialysis and Hemodiafiltration
Rationale: The mortality of end-stage renal disease (ESRD) patients on dialysis remains high. This may at least be partly due to the insufficient removal of (especially protein-bound) uremic toxins which have been associated with…
- Trial name
- NCT01328119
- Testing
- 4-hour HD, 4-hour HDF, 8-hour HD and 8-hour HDF
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Hemodiafiltration, Chronic Kidney Disease Requiring Chronic Dialysis
Effect of Hemodiafiltration Plus MCOs on Uremic Toxins Removal
Conventional hemodialysis is essential for the treatment of ESRD patients by reducing serum concentration of uremic toxins and correcting fluid overload. Nevertheless, HD removes almost exclusively low-range uremic toxins.
- Trial name
- NCT03938285
- Testing
- Theranova 400 membrane, FxCordiax 120 membrane
- Where
- 2 sites in Mexico
- Volunteers
- 12 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Kidney Failure, Chronic
Effects of Probiotics on the Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to investigate the effects of oral administration of probiotics on the metabolism of uremic toxins, in the patients with End Stage Renal Disease (ESRD).
- Trial name
- NCT03010735
- Testing
- probiotics
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- China Agricultural University
Hemolytic-Uremic Syndrome
Efficacy of INM004 in Children With STEC-HUS
The objectives of this study are to evaluate the efficacy, safety, and pharmacokinetics of INM004 in pediatric patients with Hemolytic Uremic Syndrome associated to infection by Shiga toxin-producing Escherichia coli (STEC-HUS).
- Trial name
- NCT06389474
- Testing
- INM004
- Where
- 52 sites in Argentina, Belgium and 7 more
- Volunteers
- 220 people
- Sponsor
- Inmunova S.A.
Sarcopenia
Roles of Uremic Toxins in Uremic Sacropenia
Background. In advanced chronic kidney disease (CKD), multiple metabolic and nutritional abnormalities may contribute to the impairment of skeletal muscle mass and function thus predisposing patients to the condition of…
- Trial name
- NCT03060590
- Where
- Taiwan
- Volunteers
- 111 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Chronic Kidney Diseases
Impact of Dapagliflozin on Intestinal Microbiota Composition and on the Metabolites Derived From the Intestinal Microbiota in Non-diabetic Chronic Renal Failure Patients
Chronic kidney disease (CKD) is a common disease affecting 10-12% of the adult population and characterize with high-risk cardiovascular morbidity and mortality with progression of CKD.
- Trial name
- DAPA-GUT (NCT05965440)
- Testing
- impact of Dapagliflozin on Intestinal Microbiota on chronic renal failure patients
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Failure
Observational Study of Kibow Biotics in Chronic Kidney Failure Patients
A specifically formulated probiotic product comprised of defined and tested microbial strains may afford renoprotection in what has been generally called "Enteric DialysisTM".
- Trial name
- NCT01450657
- Testing
- Kibow Biotics/Renadyl
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kibow Pharma
Chronic Kidney Diseases
Uremic Toxins and Outcomes in Chronic Kidney Disease
The aim of this cohort study is: To investigate the etiology and epidemiology of comorbidities in CKD; To find out risk factors associated with the mortality of CKD; To find out uremic toxins which are related to the mortality…
- Trial name
- NCT03711617
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Dialysis
Comparison of Hemodialysis Techniques in the Removal of Uremic Toxins in Chronic Renal Failure
In recent years, expanded hemodialysis has been the subject of studies, many of them done on small populations, with limited observation periods and not always unambiguous results.
- Trial name
- EMPIRE (NCT06794216)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Renal Failure
Uremic Toxins in the ICU: Patients After Cardiac Surgery
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients after cardiac surgery.The sampling of blood and dialysate will be done during dialyses with…
- Trial name
- NCT00752804
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- University Hospital, Ghent
Renal Failure
Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production
Chronic kidney disease (CKD) is associated with accumulation of uremic toxins like p-cresyl sulfate and indoxyl sulfate that are associated of cardiovascular complication and perturbation of glucose metabolism.
- Trial name
- KETO-GUT (NCT03959228)
- Testing
- keto-analogs
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Failure
Observational Study of Kibow Biotics in Dialysis Patients
A specifically formulated probiotic product comprised of defined and tested microbial strains may afford renoprotection in what has been generally called "Enteric DialysisTM".
- Trial name
- NCT01450670
- Testing
- Kibow Biotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kibow Pharma